Synonym
Metamfepramone hydrochloride; NSC 234706; NSC-234706; NSC234706; N,N-DMC; N,N-Dimethylcathinone HCl; N,N-DMC;
IUPAC/Chemical Name
1-Propanone, 2-(dimethylamino)-1-phenyl- hydrochloride
InChi Key
APOWZIQNQJSLKG-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H15NO.ClH/c1-9(12(2)3)11(13)10-7-5-4-6-8-10;/h4-9H,1-3H3;1H
SMILES Code
CC(N(C)C)C(C1=CC=CC=C1)=O.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Biological target:
Metamfepramone is a sympathomimetic agent metamfepramone.
|
Solvent |
mg/mL |
mM |
comments |
| Solubility |
| DMF |
1.0 |
4.68 |
|
| DMSO |
2.0 |
9.36 |
|
| Ethanol |
2.0 |
9.36 |
|
| Methanol |
1.0 |
4.68 |
|
| PBS (pH 7.2) |
10.0 |
46.79 |
|
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
213.71
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Thevis M, Sigmund G, Thomas A, Gougoulidis V, Rodchenkov G, Schänzer W. Doping control analysis of metamfepramone and two major metabolites using liquid chromatography-tandem mass spectrometry. Eur J Mass Spectrom (Chichester). 2009;15(4):507-15. doi: 10.1255/ejms.1010. PubMed PMID: 19661559.
2: Rispoli V, Rotiroti D, Carelli V, Liberatore F, Scipione L, Marra R, Giorgioni G, Di Stefano A. Choline pivaloyl esters improve in rats cognitive and memory performances impaired by scopolamine treatment or lesions of the nucleus basalis of Meynert. Neurosci Lett. 2004 Feb 19;356(3):199-202. PubMed PMID: 15036629.
3: Pokrajac M, Miljković B, Misailović B. Mass spectrometric investigation of 2-aminopropiophenones and some of their metabolites. Rapid Commun Mass Spectrom. 1991 Feb;5(2):59-61. PubMed PMID: 1804406.
4: Markantonis SL, Kyroudis A, Beckett AH. The in vitro reduction of dimethylpropion. Biochem Med Metab Biol. 1989 Aug;42(1):1-8. PubMed PMID: 2775559.
5: Markantonis SL, Kyroudis A, Beckett AH. Evaluation of the percutaneous absorption and metabolism of some aminopropiophenones. J Pharm Pharmacol. 1986 Jul;38(7):515-9. PubMed PMID: 2875152.
6: Markantonis SL, Kyroudis A, Beckett AH. The stereoselective metabolism of dimethylpropion and monomethylpropion. Biochem Pharmacol. 1986 Feb 1;35(3):529-32. PubMed PMID: 3947386.
7: Soholing WE. [Therapy of the orthostatic syndrome. Studies using dimepropion-HCI]. Fortschr Med. 1982 Feb 18;100(7):289-93. German. PubMed PMID: 7042502.
