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MedKoo Cat#: 592174 | Name: Piperic acid
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Piperic acid is a powerful antioxidant and has strong antibacterial properties

Chemical Structure

Piperic acid
Piperic acid
CAS# 5285-18-7

Theoretical Analysis

MedKoo Cat#: 592174

Name: Piperic acid

CAS#: 5285-18-7

Chemical Formula: C12H10O4

Exact Mass: 218.0579

Molecular Weight: 218.21

Elemental Analysis: C, 66.05; H, 4.62; O, 29.33

Price and Availability

Size Price Availability Quantity
1g USD 250.00
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Related CAS #
No Data
Synonym
Piperic acid; NSC 129538; NSC-129538; NSC129538
IUPAC/Chemical Name
2,4-Pentadienoic acid, 5-(1,3-benzodioxol-5-yl)- (9CI)
InChi Key
RHBGITBPARBDPH-ZPUQHVIOSA-N
InChi Code
InChI=1S/C12H10O4/c13-12(14)4-2-1-3-9-5-6-10-11(7-9)16-8-15-10/h1-7H,8H2,(H,13,14)/b3-1+,4-2+
SMILES Code
O=C(O)/C=C/C=C/C1=CC=C(OCO2)C2=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2932999099
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Piperic acid is a powerful antioxidant and has strong antibacterial properties.
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 218.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1: Sakagami H, Uesawa Y, Masuda Y, Tomomura M, Yokose S, Miyashiro T, Murai J, Takao K, Kanamoto T, Terakubo S, Kagaya H, Nakashima H, Sugita Y. Quantitative Structure-Cytotoxicity Relationship of Newly Synthesized Piperic Acid Esters. Anticancer Res. 2017 Nov;37(11):6161-6168. PubMed PMID: 29061797. 2: Wani NA, Singh S, Farooq S, Shankar S, Koul S, Khan IA, Rai R. Amino acid amides of piperic acid (PA) and 4-ethylpiperic acid (EPA) as NorA efflux pump inhibitors of Staphylococcus aureus. Bioorg Med Chem Lett. 2016 Sep 1;26(17):4174-8. doi: 10.1016/j.bmcl.2016.07.062. Epub 2016 Jul 27. PubMed PMID: 27503686. 3: Takao K, Miyashiro T, Sugita Y. Synthesis and biological evaluation of piperic acid amides as free radical scavengers and α-glucosidase inhibitors. Chem Pharm Bull (Tokyo). 2015;63(5):326-33. doi: 10.1248/cpb.c14-00874. PubMed PMID: 25948326. 4: A R, Bao N, Sun Z, Borjihan G, Qiao Y, Jin Z. Synthesis and antihyperlipidemic activity of piperic acid derivatives. Nat Prod Commun. 2015 Feb;10(2):289-90. PubMed PMID: 25920263. 5: Ali Y, Alam MS, Hamid H, Husain A, Bano S, Dhulap A, Kharbanda C, Nazreen S, Haider S. Design, synthesis and biological evaluation of piperic acid triazolyl derivatives as potent anti-inflammatory agents. Eur J Med Chem. 2015 Mar 6;92:490-500. doi: 10.1016/j.ejmech.2015.01.001. Epub 2015 Jan 7. PubMed PMID: 25596479. 6: Choochana P, Moungjaroen J, Jongkon N, Gritsanapan W, Tangyuenyongwatana P. Development of piperic acid derivatives from Piper nigrum as UV protection agents. Pharm Biol. 2015 Apr;53(4):477-82. doi: 10.3109/13880209.2014.924020. Epub 2014 Dec 4. PubMed PMID: 25471519. 7: Shimada C, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Miyashiro T, Sugita Y, Sakagami H. Quantitative structure-cytotoxicity relationship of piperic acid amides. Anticancer Res. 2014 Sep;34(9):4877-84. PubMed PMID: 25202069. 8: Dubey SK, Sharma AK, Narain U, Misra K, Pati U. Design, synthesis and characterization of some bioactive conjugates of curcumin with glycine, glutamic acid, valine and demethylenated piperic acid and study of their antimicrobial and antiproliferative properties. Eur J Med Chem. 2008 Sep;43(9):1837-46. doi: 10.1016/j.ejmech.2007.11.027. Epub 2007 Dec 8. PubMed PMID: 18201805. 9: Mishra S, Narain U, Mishra R, Misra K. Design, development and synthesis of mixed bioconjugates of piperic acid-glycine, curcumin-glycine/alanine and curcumin-glycine-piperic acid and their antibacterial and antifungal properties. Bioorg Med Chem. 2005 Mar 1;13(5):1477-86. PubMed PMID: 15698763. 10: ACHESON RM, ATKINS GL. The metabolites of piperic acid and some related compounds in the rat. Biochem J. 1961 May;79:268-70. PubMed PMID: 13681210; PubMed Central PMCID: PMC1205832.