EP6 | CAS#1353567-32-4 | 5-LO inhibitor

MedKoo Cat#: 558412 | Name: EP6

Description:

WARNING: This product is for research use only, not for human or veterinary use.

EP6 is a 5-lipoxygenase (5-LO) inhibitor. 5-LO is a crucial enzyme of the arachidonic acid (AA) cascade and catalyzes the formation of bioactive leukotrienes (LTs) which are involved in inflammatory diseases and allergic reactions.

Chemical Structure

EP6

CAS#1353567-32-4

Theoretical Analysis

MedKoo Cat#: 558412

Name: EP6

CAS#: 1353567-32-4

Chemical Formula: C24H30N4O

Exact Mass: 390.2400

Molecular Weight: 390.53

Elemental Analysis: C, 73.81; H, 7.74; N, 14.35; O, 4.10

Price and Availability

Size	Price	Availability
50mg	USD 450.00	2 Weeks
100mg	USD 750.00	2 Weeks
200mg	USD 1,250.00	2 Weeks
500mg	USD 2,650.00	2 Weeks
1g	USD 3,850.00	2 Weeks
2g	USD 5,850.00	2 Weeks

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

1353567-32-4

Synonym

EP6; EP-6; EP 6;

IUPAC/Chemical Name

N-Cyclohexyl-6-methyl-2-[4-(4-morpholinyl)phenyl]-imidazo[1,2-a]pyridin-3-amine

InChi Key

ITCJJNJMYCQGTM-UHFFFAOYSA-N

InChi Code

InChI=1S/C24H30N4O/c1-18-7-12-22-26-23(24(28(22)17-18)25-20-5-3-2-4-6-20)19-8-10-21(11-9-19)27-13-15-29-16-14-27/h7-12,17,20,25H,2-6,13-16H2,1H3

SMILES Code

CC1=CN2C(C=C1)=NC(C3=CC=C(N4CCOCC4)C=C3)=C2NC5CCCCC5

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 390.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Wisniewska JM, Rödl CB, Kahnt AS, Buscató El, Ulrich S, Tanrikulu Y, Achenbach J, Rörsch F, Grösch S, Schneider G, Cinatl J Jr, Proschak E, Steinhilber D, Hofmann B. Molecular characterization of EP6--a novel imidazo[1,2-a]pyridine based direct 5-lipoxygenase inhibitor. Biochem Pharmacol. 2012 Jan 15;83(2):228-40. doi: 10.1016/j.bcp.2011.10.012. Epub 2011 Oct 18. PubMed PMID: 22027220. 2: Pires ES, Choudhury AK, Idicula-Thomas S, Khole VV. Anti-HSP90 autoantibodies in sera of infertile women identify a dominant, conserved epitope EP6 (380-389) of HSP90 beta protein. Reprod Biol Endocrinol. 2011 Jan 27;9:16. doi: 10.1186/1477-7827-9-16. PubMed PMID: 21272367; PubMed Central PMCID: PMC3039567. 3: Smith MC, Sephel GC, Woodward SC. Spreadsheet templates for calculating linearity according to EP6-P. MLO Med Lab Obs. 1992 Nov;24(11):59-60, 62. PubMed PMID: 10122447. 4: Leontiou CA, Hadjidaniel MD, Mina P, Antoniou P, Ioannides M, Patsalis PC. Bisulfite Conversion of DNA: Performance Comparison of Different Kits and Methylation Quantitation of Epigenetic Biomarkers that Have the Potential to Be Used in Non-Invasive Prenatal Testing. PLoS One. 2015 Aug 6;10(8):e0135058. doi: 10.1371/journal.pone.0135058. eCollection 2015. PubMed PMID: 26247357; PubMed Central PMCID: PMC4527772. 5: Jeffery S, Morgan S. An unreported RFLP for probe 218 EP6 that is useful in linkage analysis of adult polycystic kidney disease. Hum Genet. 1993 Oct;92(4):428. PubMed PMID: 7901145. 6: Hajjaj F, Yoon ZS, Yoon MC, Park J, Satake A, Kim D, Kobuke Y. Assemblies of supramolecular porphyrin dimers in pentagonal and hexagonal arrays exhibiting light-harvesting antenna function. J Am Chem Soc. 2006 Apr 12;128(14):4612-23. PubMed PMID: 16594698. 7: Kumar V, Damodharan S, Pandaranayaka EP, Madathiparambil MG, Tennyson J. Molecular modeling and in-silico engineering of Cardamom mosaic virus coat protein for the presentation of immunogenic epitopes of Leptospira LipL32. J Biomol Struct Dyn. 2016;34(1):42-56. doi: 10.1080/07391102.2015.1009491. Epub 2015 Feb 18. PubMed PMID: 25692534. 8: Zhou Q, Xu J, Xie W, Li S, Li X. Linearity study of blood calcium test. Clin Lab. 2011;57(5-6):327-31. PubMed PMID: 21755822. 9: Ko DH, Jeong TD, Lee W, Chun S, Min WK. Performance Evaluation of a Restored Dimension TACR Assay: An Automated Platform for Measuring the Whole Blood Tacrolimus Concentration. Clin Lab. 2016;62(1-2):7-12. PubMed PMID: 27012028. 10: Günther V, Mueller D, von Eckardstein A, Saleh L. Head to head evaluation of the analytical performance of two commercial methotrexate immunoassays and comparison with liquid chromatography-mass spectrometry and the former fluorescence polarization immunoassay. Clin Chem Lab Med. 2016 May;54(5):823-31. doi: 10.1515/cclm-2015-0578. PubMed PMID: 26457783. 11: Maesa JM, Fernández-Riejos P, Mora CS, de Toro M, Valladares PM, González-Rodriguez C. Evaluation of Bio-Rad D-100 HbA1c analyzer against Tosoh G8 and Menarini HA-8180V. Pract Lab Med. 2016 May 14;5:57-64. doi: 10.1016/j.plabm.2016.05.002. eCollection 2016 Aug 1. PubMed PMID: 28856205; PubMed Central PMCID: PMC5574509. 12: Shipkova M, Vogeser M, Ramos PA, Verstraete AG, Orth M, Schneider C, Wallemacq P. Multi-center analytical evaluation of a novel automated tacrolimus immunoassay. Clin Biochem. 2014 Aug;47(12):1069-77. doi: 10.1016/j.clinbiochem.2014.03.023. Epub 2014 Apr 12. PubMed PMID: 24721684. 13: Li Y, Zhuang J, Huang X, Zhang Y, Lin D, Huang B, Qu P, Zeng J, Zhang X, Liu J, Xia F, Chen C. Performance evaluation of a new high throughput Mindray BS-2000M1 clinical chemistry system. Clin Biochem. 2014 Aug;47(12):1078-83. doi: 10.1016/j.clinbiochem.2014.03.020. Epub 2014 Apr 5. PubMed PMID: 24713398. 14: Greenwald I, Coulson A, Sulston J, Priess J. Correlation of the physical and genetic maps in the lin-12 region of Caenorhabditis elegans. Nucleic Acids Res. 1987 Mar 11;15(5):2295-307. PubMed PMID: 2882468; PubMed Central PMCID: PMC340635. 15: Schlacher A, Stanzer T, Osprian I, Mischitz M, Klingsbichel E, Faber K, Schwab H. Detection of a new enzyme for stereoselective hydrolysis of linalyl acetate using simple plate assays for the characterization of cloned esterases from Burkholderia gladioli. J Biotechnol. 1998 Jun 11;62(1):47-54. PubMed PMID: 9684341. 16: Vogeser M, Shipkova M, Rigo-Bonnin R, Wallemacq P, Orth M, Widmann M, Verstraete AG. Multicenter analytical evaluation of the automated electrochemiluminescence immunoassay for cyclosporine. Ther Drug Monit. 2014 Oct;36(5):640-50. doi: 10.1097/FTD.0000000000000068. PubMed PMID: 24646730; PubMed Central PMCID: PMC4218761. 17: Uhde K, Fischer R, Commandeur U. Expression of multiple foreign epitopes presented as synthetic antigens on the surface of Potato virus X particles. Arch Virol. 2005 Feb;150(2):327-40. Epub 2004 Oct 20. PubMed PMID: 15503224. 18: Paximadi E, Karakasiliotis I, Mamuris Z, Stathopoulos C, Krikelis V, Markoulatos P. Genomic analysis of recombinant sabin clinical isolates. Virus Genes. 2006 Apr;32(2):203-10. PubMed PMID: 16604453. 19: Distefano S, Palma JM, Gómez M, Río LA. Characterization of endoproteases from plant peroxisomes. Biochem J. 1997 Oct 15;327 ( Pt 2):399-405. PubMed PMID: 9359407; PubMed Central PMCID: PMC1218807. 20: Martinuzzo ME, Ujhelly C, Barrera LH, Adamo MA, Lopez MS, Otaso JC, Oyhamburu J. Validation of an Automated Immunoturbidimetric Assay for Fibrinogen/Fibrin Degradation Products Measurement and its Correlation to a Semi-Quantitative Latex Agglutination Test. Clin Lab. 2016 Nov 1;62(11):2085-2089. doi: 10.7754/Clin.Lab.2016.160223. PubMed PMID: 28164666.

View History

Glasdegib (PF-04449913)

New Featured

MedKoo CAT#: 205582

CAS#: 1095173-27-5 (free base)

5mg / USD 110.00