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MedKoo Cat#: 597811 | Name: TRH tartrate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TRH tartrate is a thyrotropin-releasing hormone.

Chemical Structure

TRH tartrate
TRH tartrate
CAS#54974-54-8

Theoretical Analysis

MedKoo Cat#: 597811

Name: TRH tartrate

CAS#: 54974-54-8

Chemical Formula: C20H28N6O10

Exact Mass: 512.1867

Molecular Weight: 512.47

Elemental Analysis: C, 46.87; H, 5.51; N, 16.40; O, 31.22

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
TRH tartrate;
IUPAC/Chemical Name
(S)-N-((S)-1-((S)-2-carbamoylpyrrolidin-1-yl)-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl)-5-oxopyrrolidine-2-carboxamide (2R,3R)-2,3-dihydroxysuccinate
InChi Key
KPUAAIHTPMAPLR-GJAJEHNISA-N
InChi Code
InChI=1S/C16H22N6O4.C4H6O6/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10;5-1(3(7)8)2(6)4(9)10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25);1-2,5-6H,(H,7,8)(H,9,10)/t10-,11-,12-;1-,2-/m01/s1
SMILES Code
O=C(N)[C@H]1N(C([C@H](CC2=CNC=N2)NC([C@H](CC3)NC3=O)=O)=O)CCC1.O=C(O)[C@H](O)[C@@H](O)C(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 512.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Nihei N, Ikeda Y, Murata Y, Kamikawa T, Suzuki Y, Yamazaki N. [Changes of plasma levels of TRH and its target hormones by two hour constant intravenous infusion of TRH tartrate in man (author's transl)]. Nihon Naibunpi Gakkai Zasshi. 1979 Sep 20;55(9):1089-97. Japanese. PubMed PMID: 115728. 2: Ogashiwa M, Takeuchi K. Clinical studies of thyrotropin-releasing hormone tartrate (TRH-T) as a direct stimulant to the central nervous system. Int J Clin Pharmacol Biopharm. 1979 Apr;17(4):145-51. PubMed PMID: 36357. 3: Yokohama S, Yamashita K, Toguchi H, Takeuchi J, Kitamori N. Absorption of thyrotropin-releasing hormone after oral administration of TRH tartrate monohydrate in the rat, dog and human. J Pharmacobiodyn. 1984 Feb;7(2):101-11. PubMed PMID: 6427443. 4: Chujo T, Sakata K, Yamada H, Sakai N, Sumi Y, Nishimura Y, Tanaka S, Ito T, Ohmae K, Nonomura O, Ohshita H, Nishiwaki T, Hirose A, Arima T, Takegoshi T. [Experimental and clinical studies on thyrotropin releasing hormone tartrate (TRH-T) for treatment of disturbances of consciousness (author's transl)]. Neurol Med Chir (Tokyo). 1980 Mar;20(3):289-301. Japanese. PubMed PMID: 6155639. 5: Yoshida N, Shimizu N, Demura R, Shizume K, Iino S. [Study of TRH tartrate as a diagnostic agent--cross comparison with TRH in a double blind test]. Horumon To Rinsho. 1976 Dec;24(12):1285-92. Japanese. PubMed PMID: 828566. 6: Wakabayashi K, Demura R, Kanda M, Demura H, Fujino R. [Clinical experience using TRH-tartrate]. Horumon To Rinsho. 1976 Oct;24(10):1063-72. Japanese. PubMed PMID: 827401. 7: Manaka S, Sano K. Thyrotropin-Releasing Hormone tartrate (TRH-T) shortens concussion effects following head impact in mice. Neurosci Lett. 1978 Jun;8(3):255-8. PubMed PMID: 19605168. 8: Miyoshi M, Takahara J, Miura H, Yamauchi J, Nakajima Y. [Changes of various hormones in successive administration of TRH-tartrate (TRH-T) (author's transl)]. Horumon To Rinsho. 1979 Sep;27(9):1055-62. Japanese. PubMed PMID: 118831. 9: Ogawa T, Moriwake T, Morimoto K, Sato M, Otsuki S. [The effect of a novel TRH analog (DN-1417) on postictal seizure inhibition in amygdaloid kindled cats]. No To Shinkei. 1984 Oct;36(10):951-5. Japanese. PubMed PMID: 6440585. 10: Hatanaka C, Obayashi M, Nishimura O, Toukai N, Fujino M. An improved synthesis of thyrotropin releasing hormone (TRH) and crystallization of the tartrate. Biochem Biophys Res Commun. 1974 Oct 23;60(4):1345-50. PubMed PMID: 4153890. 11: Nistri A. [Mechanism of action of protirelin tartrate (TRH-T) on spinal motor neurons]. Ann Ital Med Int. 1990 Jul-Sep;5(3 Pt 2):245-8. Italian. PubMed PMID: 2127685. 12: Civardi C, Naldi P, Cantello R, Gianelli M, Mutani R. Protirelin tartrate (TRH-T) in upper motoneuron syndrome: a controlled neurophysiological and clinical study. Ital J Neurol Sci. 1994 Nov;15(8):395-406. PubMed PMID: 7875957. 13: Nakayama T, Nagai Y. Effects of thyrotrophin-releasing hormone tartrate and its sustained release formulation on cerebral glucose metabolism in aged rats. J Pharm Pharmacol. 1997 Sep;49(9):884-91. PubMed PMID: 9306256. 14: Squadrito G. [Role of protirelin tartrate (TRH-T) in the recovery of post-stroke patients]. Ann Ital Med Int. 1990 Jul-Sep;5(3 Pt 2):229-31. Italian. PubMed PMID: 2078476. 15: Ofuji N, Miyoshi M, Takahara J. Influence of synthetic thyrotropin-releasing hormone tartrate monohydrate on plasma gonadotropin concentration of normal males. Endocrinol Jpn. 1977 Apr;24(2):203-6. PubMed PMID: 406136. 16: Khomane K, Kumar L, Meena CL, Jain R, Bansal A. NP-647, a novel TRH analogue: investigating physicochemical parameters critical for its oral and parenteral delivery. Int J Pharm. 2011 Mar 15;406(1-2):21-30. doi: 10.1016/j.ijpharm.2010.12.025. Epub 2010 Dec 24. PubMed PMID: 21185925. 17: Raffaele R, Cosentino E, Anicito MB, Sciacca A, Rampello L, Pennisi G, Genazzani AA, Bosco G, Casabona A, Drago F. Effects of TRH-T on spinal motoneurones in man. Neuroreport. 1992 Nov;3(11):1017-8. PubMed PMID: 1482759. 18: Takeuchi Y, Matsushita H, Kawano H, Sakai H, Yoshimoto K, Sawada T. TRH increases cerebrospinal fluid concentration of kynurenine. Neuroreport. 1999 Nov 26;10(17):3601-3. PubMed PMID: 10619651. 19: Merola B, Colao A, Di Renzo G, Filla A, Campanella G, Lombardi G. Effects of tartrate thyrotropin-releasing hormone treatment on serum thyrotropin, free triiodothyronine, free thyroxine and prolactin levels in patients with spinocerebellar degeneration. Horm Res. 1992;38(3-4):160-3. PubMed PMID: 1306848. 20: Sobue I, Takayanagi T, Nakanishi T, Tsubaki T, Uono M, Kinoshita M, Igata A, Miyazaki M, Yoshida M, Ando K, et al. Controlled trial of thyrotropin releasing hormone tartrate in ataxia of spinocerebellar degenerations. J Neurol Sci. 1983 Oct;61(2):235-48. PubMed PMID: 6417282.