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MedKoo Cat#: 596299 | Name: Ferric citrate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ferric citrate provides a source of iron used in cell culture applications. Provides iron in a less toxic form than free iron salts.

Chemical Structure

Ferric citrate
Ferric citrate
CAS#28633-45-6

Theoretical Analysis

MedKoo Cat#: 596299

Name: Ferric citrate

CAS#: 28633-45-6

Chemical Formula: C6H5FeO7

Exact Mass:

Molecular Weight: 244.94

Elemental Analysis: C, 29.42; H, 2.06; Fe, 22.80; O, 45.72

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Ferric citrate; JTT 751; EINECS 249-117-0;
IUPAC/Chemical Name
iron(III) 2-hydroxypropane-1,2,3-tricarboxylate
InChi Key
NPFOYSMITVOQOS-UHFFFAOYSA-K
InChi Code
InChI=1S/C6H8O7.Fe/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);/q;+3/p-3
SMILES Code
OC(C([O-])=O)(CC([O-])=O)CC([O-])=O.[Fe+3]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 244.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Nakayama M, Tani Y, Zhu WJ, Watanabe K, Yokoyama K, Fukagawa M, Akiba T, Wolf M, Hirakata H. Oral Ferric Citrate Hydrate Associated With Less Oxidative Stress Than Intravenous Saccharated Ferric Oxide. Kidney Int Rep. 2017 Nov 3;3(2):364-373. doi: 10.1016/j.ekir.2017.10.016. eCollection 2018 Mar. PubMed PMID: 29725640; PubMed Central PMCID: PMC5932126. 2: Scheers NM, Pereira DIA, Faria N, Powell JJ. Ferric citrate and ferric EDTA but not ferrous sulfate drive amphiregulin-mediated activation of the MAP kinase ERK in gut epithelial cancer cells. Oncotarget. 2018 Mar 30;9(24):17066-17077. doi: 10.18632/oncotarget.24899. eCollection 2018 Mar 30. PubMed PMID: 29682205; PubMed Central PMCID: PMC5908306. 3: Lupino KM, Romano KA, Simons MJ, Gregg JT, Panepinto L, Cruz GM, Grajek L, Caputo GA, Hickman MJ, Hecht GB. A Recurrent Silent Mutation Implicates fecA in Ethanol Tolerance by Escherichia coli. BMC Microbiol. 2018 Apr 18;18(1):36. doi: 10.1186/s12866-018-1180-1. PubMed PMID: 29669516; PubMed Central PMCID: PMC5907409. 4: Blum SE, Goldstone RJ, Connolly JPR, Répérant-Ferter M, Germon P, Inglis NF, Krifucks O, Mathur S, Manson E, Mclean K, Rainard P, Roe AJ, Leitner G, Smith DGE. Postgenomics Characterization of an Essential Genetic Determinant of Mammary Pathogenic Escherichia coli. MBio. 2018 Apr 3;9(2). pii: e00423-18. doi: 10.1128/mBio.00423-18. PubMed PMID: 29615502; PubMed Central PMCID: PMC5885034. 5: Pergola PE, Fishbane S, LeWinter RD, Neylan JF, Uhlig K, Block GA, Chertow GM. Hemoglobin response to ferric citrate in patients with nondialysis-dependent chronic kidney disease and iron deficiency anemia. Am J Hematol. 2018 Mar 25. doi: 10.1002/ajh.25088. [Epub ahead of print] PubMed PMID: 29575100. 6: Alencar DB, Diniz JC, Rocha SAS, Pires-Cavalcante KMS, Lima RL, Sousa KC, Freitas JO, Bezerra RM, Baracho BM, Sampaio AH, Viana FA, Saker-Sampaio S. Fatty acid composition from the marine red algae Pterocladiella capillacea (S. G. Gmelin) Santelices & Hommersand 1997 and Osmundaria obtusiloba (C. Agardh) R. E. Norris 1991 and its antioxidant activity. An Acad Bras Cienc. 2018 Jan-Mar;90(1):449-459. doi: 10.1590/0001-3765201820160315. Epub 2018 Feb 1. PubMed PMID: 29424393. 7: Sarver JL, Zhang M, Liu L, Nyenhuis D, Cafiso DS. A Dynamic Protein-Protein Coupling between the TonB-Dependent Transporter FhuA and TonB. Biochemistry. 2018 Feb 13;57(6):1045-1053. doi: 10.1021/acs.biochem.7b01223. Epub 2018 Jan 26. PubMed PMID: 29338257; PubMed Central PMCID: PMC5811355. 8: Wu MY, Chen YC, Lin CH, Wu YC, Tu YK, Tarng DC. Safety and efficacy of ferric citrate in phosphate reduction and iron supplementation in patients with chronic kidney disease. Oncotarget. 2017 Oct 20;8(63):107283-107294. doi: 10.18632/oncotarget.21990. eCollection 2017 Dec 5. PubMed PMID: 29291028; PubMed Central PMCID: PMC5739813. 9: Zou Y, Zhao L, Feng G, Miao Y, Wu H, Zeng M. Characterization of Key Factors of Anchovy (Engraulis japonicus) Meat in the Nanoparticle-Mediated Enhancement of Non-Heme Iron Absorption. J Agric Food Chem. 2017 Dec 27;65(51):11212-11219. doi: 10.1021/acs.jafc.7b04547. Epub 2017 Dec 12. PubMed PMID: 29199426. 10: Picceri GG, Leonardi P, Iotti M, Gallo M, Baldi F, Zambonelli A, Amicucci A, Vallorani L, Piccoli G, Ciccimarra G, Arshakyan M, Burattini S, Falcieri E, Chiarantini L. Bacteria-produced ferric exopolysaccharide nanoparticles as iron delivery system for truffles (Tuber borchii). Appl Microbiol Biotechnol. 2018 Feb;102(3):1429-1441. doi: 10.1007/s00253-017-8615-8. Epub 2017 Nov 30. PubMed PMID: 29189902. 11: Chertow GM, Block GA, Neylan JF, Pergola PE, Uhlig K, Fishbane S. Safety and efficacy of ferric citrate in patients with nondialysis-dependent chronic kidney disease. PLoS One. 2017 Nov 29;12(11):e0188712. doi: 10.1371/journal.pone.0188712. eCollection 2017. PubMed PMID: 29186198; PubMed Central PMCID: PMC5706696. 12: Iguchi A, Yamamoto S, Yamazaki M, Tasaki K, Suzuki Y, Kazama JJ, Narita I. Effect of ferric citrate hydrate on FGF23 and PTH levels in patients with non-dialysis-dependent chronic kidney disease with normophosphatemia and iron deficiency. Clin Exp Nephrol. 2017 Nov 27. doi: 10.1007/s10157-017-1510-x. [Epub ahead of print] PubMed PMID: 29181658. 13: Yokoyama K, Fukagawa M, Akiba T, Nakayama M, Otoguro T, Yamada K, Nagamine Y, Fishbane S, Hirakata H. Ferritin Elevation and Improved Responsiveness to Erythropoiesis-Stimulating Agents in Patients on Ferric Citrate Hydrate. Kidney Int Rep. 2017 Jan 5;2(3):359-365. doi: 10.1016/j.ekir.2016.12.005. eCollection 2017 May. PubMed PMID: 29142965; PubMed Central PMCID: PMC5678664. 14: Pi H, Helmann JD. Sequential induction of Fur-regulated genes in response to iron limitation in Bacillus subtilis. Proc Natl Acad Sci U S A. 2017 Nov 28;114(48):12785-12790. doi: 10.1073/pnas.1713008114. Epub 2017 Nov 13. PubMed PMID: 29133393; PubMed Central PMCID: PMC5715773. 15: Chang TY, Liu KL, Chang CS, Su CT, Chen SH, Lee YC, Chang JS. Ferric Citrate Supplementation Reduces Red-Blood-Cell Aggregation and Improves CD163+ Macrophage-Mediated Hemoglobin Metabolism in a Rat Model of High-Fat-Diet-Induced Obesity. Mol Nutr Food Res. 2018 Jan;62(2). doi: 10.1002/mnfr.201700442. Epub 2017 Dec 29. PubMed PMID: 29064631. 16: Putz I, Brock O. Elastic network model of learned maintained contacts to predict protein motion. PLoS One. 2017 Aug 30;12(8):e0183889. doi: 10.1371/journal.pone.0183889. eCollection 2017. PubMed PMID: 28854238; PubMed Central PMCID: PMC5576689. 17: Ling L, Zhang D, Fan C, Shang C. A Fe(II)/citrate/UV/PMS process for carbamazepine degradation at a very low Fe(II)/PMS ratio and neutral pH: The mechanisms. Water Res. 2017 Nov 1;124:446-453. doi: 10.1016/j.watres.2017.07.066. Epub 2017 Jul 27. PubMed PMID: 28783498. 18: Li P, Zhou B, Cao X, Tang X, Yang L, Hu L, Liu J. Functionalized Acupuncture Needle as Surface-Enhanced Resonance Raman Spectroscopy Sensor for Rapid and Sensitive Detection of Dopamine in Serum and Cerebrospinal Fluid. Chemistry. 2017 Oct 12;23(57):14278-14285. doi: 10.1002/chem.201702607. Epub 2017 Sep 12. PubMed PMID: 28722332. 19: Zhang Y, Wan D, Zhou X, Long C, Wu X, Li L, He L, Huang P, Chen S, Tan B, Yin Y. Diurnal variations in iron concentrations and expression of genes involved in iron absorption and metabolism in pigs. Biochem Biophys Res Commun. 2017 Sep 2;490(4):1210-1214. doi: 10.1016/j.bbrc.2017.06.187. Epub 2017 Jul 1. PubMed PMID: 28673786. 20: Garbowski MW, Evans P, Vlachodimitropoulou E, Hider R, Porter JB. Residual erythropoiesis protects against myocardial hemosiderosis in transfusion-dependent thalassemia by lowering labile plasma iron via transient generation of apotransferrin. Haematologica. 2017 Oct;102(10):1640-1649. doi: 10.3324/haematol.2017.170605. Epub 2017 Jun 22. PubMed PMID: 28642302; PubMed Central PMCID: PMC5622848.

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