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MedKoo Cat#: 558403 | Name: VU0366248

Description:

WARNING: This product is for research use only, not for human or veterinary use.

VU0366248 is a negative allosteric modulator of mGlu5.

Chemical Structure

VU0366248
VU0366248
CAS#1243310-20-4

Theoretical Analysis

MedKoo Cat#: 558403

Name: VU0366248

CAS#: 1243310-20-4

Chemical Formula: C14H7ClF2N2O

Exact Mass: 292.0200

Molecular Weight: 292.67

Elemental Analysis: C, 57.46; H, 2.41; Cl, 12.11; F, 12.98; N, 9.57; O, 5.47

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
VU0366248; VU-0366248; VU 0366248;
IUPAC/Chemical Name
N-(3-Chloro-2-fluorophenyl)-3-cyano-5-fluoro-benzamide
InChi Key
QDFPSPIHFOODSP-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H7ClF2N2O/c15-11-2-1-3-12(13(11)17)19-14(20)9-4-8(7-18)5-10(16)6-9/h1-6H,(H,19,20)
SMILES Code
O=C(NC1=CC=CC(Cl)=C1F)C2=CC(F)=CC(C#N)=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 292.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Identification of Specific Ligand–Receptor Interactions That Govern Binding and Cooperativity of Diverse Modulators to a Common Metabotropic Glutamate Receptor 5 Allosteric Site Karen J. Gregory, Elizabeth D. Nguyen, Chrysa Malosh, Jeffrey L. Mendenhall, Jessica Z. Zic, Brittney S. Bates, Meredith J. Noetzel, Emma F. Squire, Eric M. Turner, Jerri M. Rook, Kyle A. Emmitte, Shaun R. Stauffer, Craig W. Lindsley, Jens Meiler, P. Jeffrey Conn ACS Chem Neurosci. 2014 Apr 16; 5(4): 282–295. Published online 2014 Feb 16. doi: 10.1021/cn400225x PMCID: PMC3990945 2: Investigating Metabotropic Glutamate Receptor 5 Allosteric Modulator Cooperativity, Affinity, and Agonism: Enriching Structure-Function Studies and Structure-Activity Relationships Karen J. Gregory, Meredith J. Noetzel, Jerri M. Rook, Paige N. Vinson, Shaun R. Stauffer, Alice L. Rodriguez, Kyle A. Emmitte, Ya Zhou, Aspen C. Chun, Andrew S. Felts, Brian A. Chauder, Craig W. Lindsley, Colleen M. Niswender, P. Jeffrey Conn Mol Pharmacol. 2012 Nov; 82(5): 860–875. doi: 10.1124/mol.112.080531 PMCID: PMC3477233 3: VU0477573: Partial Negative Allosteric Modulator of the Subtype 5 Metabotropic Glutamate Receptor with In Vivo Efficacy Hilary Highfield Nickols, Joannes P. Yuh, Karen J. Gregory, Ryan D. Morrison, Brittney S. Bates, Shaun R. Stauffer, Kyle A. Emmitte, Michael Bubser, Weimin Peng, Michael T. Nedelcovych, Analisa Thompson, Xiaohui Lv, Zixiu Xiang, J. Scott Daniels, Colleen M. Niswender, Craig W. Lindsley, Carrie K. Jones, P. Jeffrey Conn J Pharmacol Exp Ther. 2016 Jan; 356(1): 123–136. Published online 2016 Jan. doi: 10.1124/jpet.115.226597 PMCID: PMC4702078 4: Molecular Insights into Metabotropic Glutamate Receptor Allosteric Modulation Karen J. Gregory, P. Jeffrey Conn Mol Pharmacol. 2015 Jul; 88(1): 188–202. Published online 2015 Jul. doi: 10.1124/mol.114.097220 PMCID: PMC4468636