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MedKoo Cat#: 563267 | Name: GSK1360707

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GSK1360707 is a potent and selective triple reuptake inhibitor (TRI).

Chemical Structure

GSK1360707
GSK1360707
CAS#1013098-04-8

Theoretical Analysis

MedKoo Cat#: 563267

Name: GSK1360707

CAS#: 1013098-04-8

Chemical Formula: C14H17Cl2NO

Exact Mass: 285.0687

Molecular Weight: 286.19

Elemental Analysis: C, 58.75; H, 5.99; Cl, 24.77; N, 4.89; O, 5.59

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
GSK1360707; GSK-1360707; GSK 1360707;
IUPAC/Chemical Name
(1S,6R)-6-(3,4-Dichlorophenyl)-1-(methoxymethyl)-3-azabicyclo[4.1.0]heptane
InChi Key
ICXJGCSEMJXNQF-KBPBESRZSA-N
InChi Code
InChI=1S/C14H17Cl2NO/c1-18-9-13-7-14(13,4-5-17-8-13)10-2-3-11(15)12(16)6-10/h2-3,6,17H,4-5,7-9H2,1H3/t13-,14-/m0/s1
SMILES Code
COC[C@]12CNCC[C@@]1(C3=CC=C(Cl)C(Cl)=C3)C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 286.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Veeranna KD, Das KK, Baskaran S. One-Pot Synthesis of Cyclopropane-Fused Cyclic Amidines: An Oxidative Carbanion Cyclization. Angew Chem Int Ed Engl. 2017 Dec 18;56(51):16197-16201. doi: 10.1002/anie.201708138. Epub 2017 Nov 27. PubMed PMID: 29083519. 2: Comley RA, Salinas CA, Slifstein M, Petrone M, Marzano C, Bennacef I, Shotbolt P, Van der Aart J, Neve M, Iavarone L, Gomeni R, Laruelle M, Gray FA, Gunn RN, Rabiner EA. Monoamine transporter occupancy of a novel triple reuptake inhibitor in baboons and humans using positron emission tomography. J Pharmacol Exp Ther. 2013 Aug;346(2):311-7. doi: 10.1124/jpet.112.202895. Epub 2013 May 17. PubMed PMID: 23685546. 3: Teller H, Fürstner A. Concise synthesis of the antidepressive drug candidate GSK1360707 by a highly enantioselective gold-catalyzed enyne cycloisomerization reaction. Chemistry. 2011 Jul 4;17(28):7764-7. doi: 10.1002/chem.201101346. Epub 2011 May 26. PubMed PMID: 21618638. 4: Deschamps NM, Elitzin VI, Liu B, Mitchell MB, Sharp MJ, Tabet EA. An enyne cycloisomerization approach to the triple reuptake inhibitor GSK1360707F. J Org Chem. 2011 Jan 21;76(2):712-5. doi: 10.1021/jo102098y. Epub 2010 Dec 21. PubMed PMID: 21174473.

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