Synonym
Norchlorcyclizine; C10; C-10; C 10;
IUPAC/Chemical Name
1-((4-chlorophenyl)(phenyl)methyl)piperazine
InChi Key
UZKBSZSTDQSMDR-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H19ClN2/c18-16-8-6-15(7-9-16)17(14-4-2-1-3-5-14)20-12-10-19-11-13-20/h1-9,17,19H,10-13H2
SMILES Code
ClC1=CC=C(C(N2CCNCC2)C3=CC=CC=C3)C=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Biological target:
Norchlorcyclizine is a partially selective NPR-B inhibitor.
|
Solvent |
mg/mL |
mM |
| Solubility |
| DMF |
30.0 |
104.60 |
| DMSO |
30.0 |
104.60 |
| DMSO:PBS (pH 7.2) (1:4) |
0.2 |
0.70 |
| Ethanol |
25.0 |
87.17 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
286.80
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Formulation protocol:
TBD
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3: Thavundayil JX, Hambalek R, Kin NM, Krishnan B, Lal S. Prolonged penile erections induced by hydroxyzine: possible mechanism of action. Neuropsychobiology. 1994;30(1):4-6. PubMed PMID: 7969858.
4: Kageura M, Kataoka M, Hara K, Nagata T. Changed compounds of hydroxyzine in a human urine. Forensic Sci Int. 1986 Dec;32(4):229-35. PubMed PMID: 3804142.
5: Wilk AL, King CT, Pratt RM. Chlorcyclizine induction of cleft palate in the rat: degradation of palatal glycosaminoglycans. Teratology. 1978 Oct;18(2):199-209. PubMed PMID: 31013.
6: Kamm JJ, Szuna A, Kuntzman R. Studies on an unusual N-dealkylation reaction. I. In vivo and in vitro N-dealkylation of N-t-butylnorchlorcyclizine to norchlorcyclizine by the rat. J Pharmacol Exp Ther. 1972 Sep;182(3):507-14. PubMed PMID: 4403434.
7: Wilk AL, Steffek AJ, King CT. Norchlorcyclizine analogs: relationship of teratogenic activity to in vitro cartilage binding. J Pharmacol Exp Ther. 1970 Jan;171(1):118-26. PubMed PMID: 4391467.
8: Wilk AL. Production of fetal rat malformations by norchlorcyclizine and chlorcyclizine after intrauterine application. Teratology. 1969 Feb;2(1):55-65. PubMed PMID: 4389241.
9: Kuntzman R, Tsai I, Burns JJ. Importance of tissue and plasma binding in determining the retention of norchlorcyclizine and norcyclizine in man, dog and rat. J Pharmacol Exp Ther. 1967 Nov;158(2):332-9. PubMed PMID: 4383640.
