Disofenin | CAS# 65717-97-7 | Diagnostic Aid (Carrier Agent)

MedKoo Cat#: 413829 | Name: Disofenin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Disofenin is a synthetic small molecule that acts as a selective antagonist of the GABA-A receptor. It inhibits chloride ion influx by binding to specific sites on the receptor, thereby modulating inhibitory neurotransmission in the central nervous system. This results in anxiolytic and sedative effects, with potential applications in managing anxiety and sleep disorders.

Chemical Structure

Disofenin

CAS#65717-97-7

Theoretical Analysis

MedKoo Cat#: 413829

Name: Disofenin

CAS#: 65717-97-7

Chemical Formula: C18H26N2O5

Exact Mass: 350.1842

Molecular Weight: 350.42

Elemental Analysis: C, 61.70; H, 7.48; N, 7.99; O, 22.83

Price and Availability

Size	Price	Availability	Quantity
250mg	USD 450.00	2 Weeks
1g	USD 850.00	2 Weeks

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Synonym

Disofenin; Disofenine; DSIDA; Disofeninum; Disofenino; Disofenina

IUPAC/Chemical Name

Glycine, N-(2-((2,6-bis(1-methylethyl)phenyl)amino)-2-oxoethyl)-N-(carboxymethyl)-

InChi Key

UDUSOMRJOPCWHT-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H26N2O5/c1-11(2)13-6-5-7-14(12(3)4)18(13)19-15(21)8-20(9-16(22)23)10-17(24)25/h5-7,11-12H,8-10H2,1-4H3,(H,19,21)(H,22,23)(H,24,25)

SMILES Code

O=C(O)CN(CC(NC1=C(C(C)C)C=CC=C1C(C)C)=O)CC(O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Disofenin is a diagnostic aid (Carrier Agent).

In vitro activity:

TBD

In vivo activity:

TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 350.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

TBD

In vitro protocol:

TBD

In vivo protocol:

TBD

1: Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. Technetium Tc 99m Disofenin. 2024 Nov 15. PMID: 30000627. 2: Tyrväinen T, Nordback I, Toikka J, Piiroinen A, Herzig KH, Mäkelä K, Sand J. Impaired gallbladder function in patients after total gastrectomy. Scand J Gastroenterol. 2017 Mar;52(3):334-337. doi: 10.1080/00365521.2016.1256422. Epub 2016 Nov 24. PMID: 27881023. 3: Fakhri AA, Hussain A, Taiyebi A, Fakhri AF. Duodenal Obstruction on 99mTc- DISIDA Cholescintigraphy: A Noninvasive Approach to Bowel Obstruction Diagnosis. J Nucl Med Technol. 2016 Dec;44(4):265-266. doi: 10.2967/jnmt.116.183822. Epub 2016 Nov 10. PMID: 27834726. 4: Salgado Júnior W, Donadelli CA, Dos Santos JS, Nonino CB. Influence of Roux- en-Y Gastric Bypass on the Hepatocellular Function and Bile Flow of Obese Patients Assessed by Scintigraphy with DISIDA. Obes Surg. 2016 Nov;26(11):2718-2723. doi: 10.1007/s11695-016-2176-2. PMID: 27094876. 5: Eckenrode AH, Ewing JA, Kotrady J, Hale AL, Smith DE. HIDA Scan with Ejection Fraction Is over Utilized in the Management of Biliary Dyskinesia. Am Surg. 2015 Jul;81(7):669-73. PMID: 26140885. 6: Lo RC, Huang WL, Fan YM. Evaluation of bile reflux in HIDA images based on fluid mechanics. Comput Biol Med. 2015 May;60:51-65. doi: 10.1016/j.compbiomed.2015.02.002. Epub 2015 Feb 24. PMID: 25754361. 7: LeBedis CA, Anderson SW, Mercier G, Kussman S, Coleman SL, Golden L, Penn DR, Uyeda JW, Soto JA. The utility of CT for predicting bile leaks in hepatic trauma. Emerg Radiol. 2015 Apr;22(2):101-7. doi: 10.1007/s10140-014-1262-9. Epub 2014 Aug 22. PMID: 25146931. 8: Fahey F, Zukotynski K, Zurakowski D, Markelewicz R, Falone A, Vitello M, Cao X, Grant F, Drubach L, Vija AH, Bhattacharya M, Ding X, Bar-Sever Z, Gelfand M, Treves ST. Beyond current guidelines: reduction in minimum administered radiopharmaceutical activity with preserved diagnostic image quality in pediatric hepatobiliary scintigraphy. Eur J Nucl Med Mol Imaging. 2014 Dec;41(12):2346-53. doi: 10.1007/s00259-014-2860-1. Epub 2014 Aug 6. PMID: 25097073. 9: Ueda CE, Ichiki WA, Ruiz MF, Santos AO, Etchebehere EC. 99mTc-DISIDA uptake in liver lesion and pulmonary metastases shown on SPECT/CT in a patient with hepatocellular carcinoma. Clin Nucl Med. 2014 Jan;39(1):74-6. doi: 10.1097/RLU.0b013e3182815d28. PMID: 23917780. 10: Brborić J, Jovanović MS, Vranješ-Đurić S, Cudina O, Marković B, Vladimirov S. The effect of lipophilicity on the hepatobiliary properties of iminodiacetic acid derivatives in the conditions of hyperbilirubinemia. Appl Radiat Isot. 2013 Apr;74:31-5. doi: 10.1016/j.apradiso.2012.12.014. Epub 2013 Jan 3. PMID: 23353095. 11: Lee SY, Kim GC, Choe BH, Ryeom HK, Jang YJ, Kim HJ, Park JY, Cho SM. Efficacy of US-guided percutaneous cholecystocholangiography for the early exclusion and type determination of biliary atresia. Radiology. 2011 Dec;261(3):916-22. doi: 10.1148/radiol.11110665. Epub 2011 Oct 13. PMID: 21998045. 12: Kim JW, Yoon H, Kong SH, Kim JS, Paeng JC, Lee HJ, Lee KU, Yang HK. Analysis of esophageal reflux after proximal gastrectomy measured by wireless ambulatory 24-hr esophageal pH monitoring and TC-99m diisopropyliminodiacetic acid (DISIDA) scan. J Surg Oncol. 2010 Jun 1;101(7):626-33. doi: 10.1002/jso.21560. PMID: 20461772. 13: Hsiao IT, Lin KJ, Chang SI, Yen TC, Chen TC, Yeh TS. Impaired liver regeneration of steatotic rats after portal vein ligation: a particular emphasis on (99m)Tc-DISIDA scintigraphy and adiponectin signaling. J Hepatol. 2010 Apr;52(4):540-9. doi: 10.1016/j.jhep.2010.01.005. Epub 2010 Feb 19. PMID: 20206399. 14: Al Sofayan MS, Ibrahim A, Helmy A, Al Saghier MI, Al Sebayel MI, Abozied MM. Nuclear imaging of the liver: is there a diagnostic role of HIDA in posttransplantation? Transplant Proc. 2009 Jan-Feb;41(1):201-7. doi: 10.1016/j.transproceed.2008.10.076. PMID: 19249514. 15: Concannon RC, Howman-Giles R, Shun A, Stormon MO. Hepatobiliary scintigraphy for the assessment of biliary strictures after pediatric liver transplantation. Pediatr Transplant. 2009 Dec;13(8):977-83. doi: 10.1111/j.1399-3046.2008.01099.x. Epub 2009 Nov 20. PMID: 19032415. 16: Jung MK, Bae MH, Kim DJ, Lee WS, Cho CM, Tak WY, Kweon YO. [A case with Rotor syndrome in hyperbilirubinemic family]. Korean J Gastroenterol. 2007 Apr;49(4):251-5. Korean. PMID: 17464171. 17: Xia CS, Yang XY, Hong GX. 99Tcm-DISIDA hepatobiliary imaging in evaluating gallbladder function in patients with spinal cord injury. Hepatobiliary Pancreat Dis Int. 2007 Apr;6(2):204-7. PMID: 17374583. 18: Ananian C, Dunn A, Mansourian V, Caride VJ. Scintigraphic gallbladder visualization with gangrenous acalculous cholecystitis. Clin Nucl Med. 2006 Nov;31(11):701-3. doi: 10.1097/01.rlu.0000242700.10483.08. PMID: 17053389. 19: Takaya J, Nakano S, Imai Y, Fujii Y, Kaneko K. Usefulness of magnetic resonance cholangiopancreatography in biliary structures in infants: a four-case report. Eur J Pediatr. 2007 Mar;166(3):211-4. doi: 10.1007/s00431-006-0230-0. Epub 2006 Sep 8. PMID: 16960695. 20: Michael M, Thompson M, Hicks RJ, Mitchell PL, Ellis A, Milner AD, Di Iulio J, Scott AM, Gurtler V, Hoskins JM, Clarke SJ, Tebbut NC, Foo K, Jefford M, Zalcberg JR. Relationship of hepatic functional imaging to irinotecan pharmacokinetics and genetic parameters of drug elimination. J Clin Oncol. 2006 Sep 10;24(26):4228-35. doi: 10.1200/JCO.2005.04.8496. Epub 2006 Aug 8. PMID: 16896007.