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MedKoo Cat#: 597757 | Name: Aspartame acesulfame

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Aspartame acesulfame is an artificial sweetener that is 350 times more sweet as sucrose.

Chemical Structure

Aspartame acesulfame
Aspartame acesulfame
CAS#106372-55-8 (acesulfame)

Theoretical Analysis

MedKoo Cat#: 597757

Name: Aspartame acesulfame

CAS#: 106372-55-8 (acesulfame)

Chemical Formula: C18H23N3O9S

Exact Mass: 0.0000

Molecular Weight: 457.45

Elemental Analysis: C, 47.26; H, 5.07; N, 9.19; O, 31.48; S, 7.01

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Related CAS #
22839-47-0 (free acid) 106372-55-8 (acesulfame)
Synonym
Aspartame acesulfame; Aspartame acesulfame salt; Acesulfame mixture with aspartame;
IUPAC/Chemical Name
6-methyl-1,2,3-oxathiazin-4(3H)-one 2,2-dioxide (S)-3-amino-4-(((S)-1-methoxy-1-oxo-3-phenylpropan-2-yl)amino)-4-oxobutanoate
InChi Key
KVHQNWGLVVERFR-ACMTZBLWSA-N
InChi Code
InChI=1S/C14H18N2O5.C4H5NO4S/c1-21-14(20)11(7-9-5-3-2-4-6-9)16-13(19)10(15)8-12(17)18;1-3-2-4(6)5-10(7,8)9-3/h2-6,10-11H,7-8,15H2,1H3,(H,16,19)(H,17,18);2H,1H3,(H,5,6)/t10-,11-;/m0./s1
SMILES Code
CC1=CC(=O)NS(=O)(=O)O1.COC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC(=O)O)N
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 457.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Arora S, Shendurse AM, Sharma V, Wadhwa BK, Singh AK. Assessment of stability of binary sweetener blend (aspartame x acesulfame-K) during storage in whey lemon beverage. J Food Sci Technol. 2013 Aug;50(4):770-6. doi: 10.1007/s13197-011-0386-0. Epub 2011 May 5. PubMed PMID: 24425980; PubMed Central PMCID: PMC3671041. 2: Vistuba JP, Dolzan MD, Vitali L, de Oliveira MA, Micke GA. Sub-minute method for simultaneous determination of aspartame, cyclamate, acesulfame-K and saccharin in food and pharmaceutical samples by capillary zone electrophoresis. J Chromatogr A. 2015 May 29;1396:148-52. doi: 10.1016/j.chroma.2015.03.070. Epub 2015 Apr 8. PubMed PMID: 25895731. 3: Kim JY, Park KH, Kim J, Choi I, Cho KH. Modified high-density lipoproteins by artificial sweetener, aspartame, and saccharin, showed loss of anti-atherosclerotic activity and toxicity in zebrafish. Cardiovasc Toxicol. 2015 Jan;15(1):79-89. doi: 10.1007/s12012-014-9273-z. PubMed PMID: 25142179. 4: Bandyopadhyay A, Ghoshal S, Mukherjee A. Genotoxicity testing of low-calorie sweeteners: aspartame, acesulfame-K, and saccharin. Drug Chem Toxicol. 2008;31(4):447-57. doi: 10.1080/01480540802390270 . PubMed PMID: 18850355. 5: Schifferstein HN. An Equiratio Mixture Model for non-additive components: a case study for aspartame/acesulfame-K mixtures. Chem Senses. 1996 Feb;21(1):1-11. PubMed PMID: 8646486. 6: Armenta S, Garrigues S, de la Guardia M. FTIR determination of Aspartame and Acesulfame-K in tabletop sweeteners. J Agric Food Chem. 2004 Dec 29;52(26):7798-803. PubMed PMID: 15612758. 7: Subedi B, Kannan K. Fate of artificial sweeteners in wastewater treatment plants in New York State, U.S.A. Environ Sci Technol. 2014 Dec 2;48(23):13668-74. doi: 10.1021/es504769c. Epub 2014 Nov 14. PubMed PMID: 25365516. 8: Mukhopadhyay M, Mukherjee A, Chakrabarti J. In vivo cytogenetic studies on blends of aspartame and acesulfame-K. Food Chem Toxicol. 2000 Jan;38(1):75-7. PubMed PMID: 10685017. 9: Lino CM, Costa IM, Pena A, Ferreira R, Cardoso SM. Estimated intake of the sweeteners, acesulfame-K and aspartame, from soft drinks, soft drinks based on mineral waters and nectars for a group of Portuguese teenage students. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2008 Nov;25(11):1291-6. doi: 10.1080/02652030802195309. PubMed PMID: 19680835. 10: Leclercq C, Berardi D, Sorbillo MR, Lambe J. Intake of saccharin, aspartame, acesulfame K and cyclamate in Italian teenagers: present levels and projections. Food Addit Contam. 1999 Mar;16(3):99-109. PubMed PMID: 10492702. 11: Ilbäck NG, Alzin M, Jahrl S, Enghardt-Barbieri H, Busk L. Estimated intake of the artificial sweeteners acesulfame-K, aspartame, cyclamate and saccharin in a group of Swedish diabetics. Food Addit Contam. 2003 Feb;20(2):99-114. PubMed PMID: 12623659. 12: Berset JD, Ochsenbein N. Stability considerations of aspartame in the direct analysis of artificial sweeteners in water samples using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Chemosphere. 2012 Jul;88(5):563-9. doi: 10.1016/j.chemosphere.2012.03.030. Epub 2012 Apr 12. PubMed PMID: 22503463. 13: Qurrat-ul-Ain, Khan SA. Artificial sweeteners: safe or unsafe? J Pak Med Assoc. 2015 Feb;65(2):225-7. Review. PubMed PMID: 25842566. 14: Frankenfeld CL, Sikaroodi M, Lamb E, Shoemaker S, Gillevet PM. High-intensity sweetener consumption and gut microbiome content and predicted gene function in a cross-sectional study of adults in the United States. Ann Epidemiol. 2015 Oct;25(10):736-42.e4. doi: 10.1016/j.annepidem.2015.06.083. Epub 2015 Jul 17. PubMed PMID: 26272781. 15: Bryant CE, Wasse LK, Astbury N, Nandra G, McLaughlin JT. Non-nutritive sweeteners: no class effect on the glycaemic or appetite responses to ingested glucose. Eur J Clin Nutr. 2014 May;68(5):629-31. doi: 10.1038/ejcn.2014.19. Epub 2014 Mar 5. PubMed PMID: 24595225; PubMed Central PMCID: PMC4012981. 16: Sylvetsky AC, Gardner AL, Bauman V, Blau JE, Garraffo HM, Walter PJ, Rother KI. Nonnutritive Sweeteners in Breast Milk. J Toxicol Environ Health A. 2015;78(16):1029-32. doi: 10.1080/15287394.2015.1053646. Epub 2015 Aug 12. PubMed PMID: 26267522; PubMed Central PMCID: PMC5583633. 17: van Eyk AD. The effect of five artificial sweeteners on Caco-2, HT-29 and HEK-293 cells. Drug Chem Toxicol. 2015;38(3):318-27. doi: 10.3109/01480545.2014.966381. Epub 2014 Oct 15. PubMed PMID: 25317478. 18: Chattopadhyay S, Raychaudhuri U, Chakraborty R. Artificial sweeteners - a review. J Food Sci Technol. 2014 Apr;51(4):611-21. doi: 10.1007/s13197-011-0571-1. Epub 2011 Oct 21. Review. PubMed PMID: 24741154; PubMed Central PMCID: PMC3982014. 19: Janvier S, Goscinny S, Le Donne C, Van Loco J. Low-calorie sweeteners in food and food supplements on the Italian market. Food Addit Contam Part B Surveill. 2015;8(4):298-308. doi: 10.1080/19393210.2015.1094829. PubMed PMID: 26406785. 20: Patil S, Ravi R, Saraswathi G, Prakash M. Development of low calorie snack food based on intense sweeteners. J Food Sci Technol. 2014 Dec;51(12):4096-101. doi: 10.1007/s13197-012-0911-9. Epub 2012 Dec 20. PubMed PMID: 25477687; PubMed Central PMCID: PMC4252414.