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MedKoo Cat#: 592138 | Name: Pomiferin
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pomiferin is a cannabinoid receptor.

Chemical Structure

Pomiferin
Pomiferin
CAS#572-03-2

Theoretical Analysis

MedKoo Cat#: 592138

Name: Pomiferin

CAS#: 572-03-2

Chemical Formula: C25H24O6

Exact Mass: 420.1573

Molecular Weight: 420.46

Elemental Analysis: C, 71.42; H, 5.75; O, 22.83

Price and Availability

Size Price Availability Quantity
1mg USD 450.00 2 Weeks
5mg USD 850.00 2 Weeks
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Related CAS #
No Data
Synonym
Pomiferin; NSC 5113; NSC-5113; NSC5113
IUPAC/Chemical Name
4H,8H-Benzo(1,2-b:3,4-b')dipyran-4-one, 3-(3,4-dihydroxyphenyl)-5-hydroxy-8,8-dimethyl-6-(3-methyl-2-butenyl)-
InChi Key
GHCZYXUOYFOXIP-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H24O6/c1-13(2)5-7-15-21(28)20-22(29)17(14-6-8-18(26)19(27)11-14)12-30-24(20)16-9-10-25(3,4)31-23(15)16/h5-6,8-12,26-28H,7H2,1-4H3
SMILES Code
O=C1C2=C(O)C(C/C=C(C)\C)=C3C(C=CC(C)(C)O3)=C2OC=C1C4=CC=C(O)C(O)=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 420.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Orazbekov Y, Ibrahim MA, Mombekov S, Srivedavyasasri R, Datkhayev U, Makhatov B, Chaurasiya ND, Tekwani BL, Ross SA. Isolation and Biological Evaluation of Prenylated Flavonoids from Maclura pomifera. Evid Based Complement Alternat Med. 2018 Jan 14;2018:1370368. doi: 10.1155/2018/1370368. eCollection 2018. PubMed PMID: 29552078; PubMed Central PMCID: PMC5820588. 2: Tóth B, Kúsz N, Forgo P, Bózsity N, Zupkó I, Pinke G, Hohmann J, Vasas A. Abietane diterpenoids from Sideritis montana L. and their antiproliferative activity. Fitoterapia. 2017 Oct;122:90-94. doi: 10.1016/j.fitote.2017.08.016. Epub 2017 Aug 31. PubMed PMID: 28864041. 3: Dilek E, Erol HS, Cakir A, Koc M, Halici MB. Natural product inhibitors of carbonic anhydrase I and II isoenzymes: osajin and pomiferin. Arch Physiol Biochem. 2017 Oct;123(4):219-224. doi: 10.1080/13813455.2017.1303742. Epub 2017 Mar 24. PubMed PMID: 28338341. 4: Ribaudo G, Vendrame T, Bova S. Isoflavones from Maclura pomifera: structural elucidation and in silico evaluation of their interaction with PDE5. Nat Prod Res. 2017 Sep;31(17):1988-1994. doi: 10.1080/14786419.2016.1269101. Epub 2016 Dec 27. PubMed PMID: 28025893. 5: Venturelli S, Burkard M, Biendl M, Lauer UM, Frank J, Busch C. Prenylated chalcones and flavonoids for the prevention and treatment of cancer. Nutrition. 2016 Nov-Dec;32(11-12):1171-8. doi: 10.1016/j.nut.2016.03.020. Epub 2016 Apr 8. Review. PubMed PMID: 27238957. 6: Abourashed EA, Abraha A, Khan SI, McCants T, Awan S. Potential of Horse Apple Isoflavones in Targeting Inflammation and Tau Protein Fibrillization. Nat Prod Commun. 2015 Sep;10(9):1577-80. PubMed PMID: 26594763. 7: Ribaudo G, Pagano MA, Pavan V, Redaelli M, Zorzan M, Pezzani R, Mucignat-Caretta C, Vendrame T, Bova S, Zagotto G. Semi-synthetic derivatives of natural isoflavones from Maclura pomifera as a novel class of PDE-5A inhibitors. Fitoterapia. 2015 Sep;105:132-8. doi: 10.1016/j.fitote.2015.06.020. Epub 2015 Jun 29. PubMed PMID: 26136059. 8: Dwivedi UN, Tiwari S, Singh P, Singh S, Awasthi M, Pandey VP. Treponema pallidum putative novel drug target identification and validation: rethinking syphilis therapeutics with plant-derived terpenoids. OMICS. 2015 Feb;19(2):104-14. doi: 10.1089/omi.2014.0154. PubMed PMID: 25683888; PubMed Central PMCID: PMC4322953. 9: Moon HI. Effect of osajin and pomiferin on antidiabetic effects from normal and streptozotocin-induced diabetic rats. Nat Prod Commun. 2014 Dec;9(12):1723-4. PubMed PMID: 25632468. 10: Gruber JV, Holtz R, Sikkink SK, Tobin DJ. In vitro and ex vivo examination of topical Pomiferin treatments. Fitoterapia. 2014 Apr;94:164-71. doi: 10.1016/j.fitote.2014.01.023. Epub 2014 Feb 8. PubMed PMID: 24513505. 11: Bajer MM, Kunze MM, Blees JS, Bokesch HR, Chen H, Brauss TF, Dong Z, Gustafson KR, Biondi RM, Henrich CJ, McMahon JB, Colburn NH, Schmid T, Brüne B. Characterization of pomiferin triacetate as a novel mTOR and translation inhibitor. Biochem Pharmacol. 2014 Apr 1;88(3):313-21. doi: 10.1016/j.bcp.2014.01.034. Epub 2014 Feb 7. PubMed PMID: 24513322; PubMed Central PMCID: PMC3978168. 12: Hošek J, Toniolo A, Neuwirth O, Bolego C. Prenylated and geranylated flavonoids increase production of reactive oxygen species in mouse macrophages but inhibit the inflammatory response. J Nat Prod. 2013 Sep 27;76(9):1586-91. doi: 10.1021/np400242e. Epub 2013 Aug 16. PubMed PMID: 23947936. 13: Zhao D, Yao C, Chen X, Xia H, Zhang L, Liu H, Jiang X, Dai Y, Liu J. The fruits of Maclura pomifera extracts inhibits glioma stem-like cell growth and invasion. Neurochem Res. 2013 Oct;38(10):2105-13. doi: 10.1007/s11064-013-1119-8. Epub 2013 Aug 9. PubMed PMID: 23929619. 14: Darji K, Miglis C, Wardlow A, Abourashed EA. HPLC determination of isoflavone levels in osage orange from the Midwest and southern United States. J Agric Food Chem. 2013 Jul 17;61(28):6806-11. doi: 10.1021/jf400954m. Epub 2013 Jul 2. PubMed PMID: 23772950; PubMed Central PMCID: PMC3774050. 15: Yang R, Hanwell H, Zhang J, Tsao R, Meckling KA. Antiproliferative activity of pomiferin in normal (MCF-10A) and transformed (MCF-7) breast epithelial cells. J Agric Food Chem. 2011 Dec 28;59(24):13328-36. doi: 10.1021/jf202898g. Epub 2011 Nov 29. PubMed PMID: 22087557. 16: Chokchaichamnankit D, Kongjinda V, Khunnawutmanotham N, Chimnoi N, Pisutcharoenpong S, Techasakul S. Prenylated flavonoids from the leaves of Derris malaccensis and their cytotoxicity. Nat Prod Commun. 2011 Aug;6(8):1103-6. PubMed PMID: 21922909. 17: Bartošíková L, Nečas J, Bartošík T, Pavlík M, Fráňa P. Effect of pomiferin administration on kidney ischaemia-reperfusion injury in rats. Interdiscip Toxicol. 2010 Jun;3(2):76-81. doi: 10.2478/v10102-010-0015-1. PubMed PMID: 21217877; PubMed Central PMCID: PMC2984129. 18: Gruber JV, Holtz R. Examining the genomic influence of skin antioxidants in vitro. Mediators Inflamm. 2010;2010. pii: 230450. doi: 10.1155/2010/230450. Epub 2010 Jul 12. PubMed PMID: 20706672; PubMed Central PMCID: PMC2913633. 19: Richard CL, Farach-Carson MC, Rohe B, Nemere I, Meckling KA. Involvement of 1,25D3-MARRS (membrane associated, rapid response steroid-binding), a novel vitamin D receptor, in growth inhibition of breast cancer cells. Exp Cell Res. 2010 Mar 10;316(5):695-703. doi: 10.1016/j.yexcr.2009.12.015. Epub 2009 Dec 28. PubMed PMID: 20036234. 20: Yang XW, Feng L, Li SM, Liu XH, Li YL, Wu L, Shen YH, Tian JM, Zhang X, Liu XR, Wang N, Liu Y, Zhang WD. Isolation, structure, and bioactivities of abiesadines A-Y, 25 new diterpenes from Abies georgei Orr. Bioorg Med Chem. 2010 Jan 15;18(2):744-54. doi: 10.1016/j.bmc.2009.11.055. Epub 2009 Dec 3. PubMed PMID: 20022253.