Jmv 320 | CAS#130582-10-4 | cyclic cholecystokinin-8 analog

MedKoo Cat#: 597746 | Name: Jmv 320

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Jmv 320 is a cyclic cholecystokinin-8 analog in which positions 28 and 31 have been replaced by Lys, with their side chains bridged by a succinic moiety; highly selective gastrin receptor and cholecystokinin receptor antagonist.

Chemical Structure

Jmv 320

CAS#130582-10-4

Theoretical Analysis

MedKoo Cat#: 597746

Name: Jmv 320

CAS#: 130582-10-4

Chemical Formula: C53H67N11O13

Exact Mass: 1065.4920

Molecular Weight: 1066.18

Elemental Analysis: C, 59.71; H, 6.33; N, 14.45; O, 19.51

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Jmv 320; Jmv-320; Jmv320;

IUPAC/Chemical Name

(S)-3-((5S,8S,23S)-5-((1H-indol-3-yl)methyl)-23-((S)-2-acetamido-3-(4-hydroxyphenyl)propanamido)-3,6,14,17,24-pentaoxo-1,4,7,13,18-pentaazacyclotetracosane-8-carboxamido)-4-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)amino)-4-oxobutanoic acid

InChi Key

CDEXDQIEKQQZDF-KHVQSSSXSA-N

InChi Code

1S/C53H67N11O13/c1-31(65)59-41(26-33-17-19-35(66)20-18-33)51(75)61-38-15-7-9-23-55-44(67)21-22-45(68)56-24-10-8-16-39(50(74)64-43(28-47(70)71)53(77)63-40(48(54)72)25-32-11-3-2-4-12-32)62-52(76)42(60-46(69)30-58-49(38)73)27-34-29-57-37-14-6-5-13-36(34)37/h2-6,11-14,17-20,29,38-43,57,66H,7-10,15-16,21-28,30H2,1H3,(H2,54,72)(H,55,67)(H,56,68)(H,58,73)(H,59,65)(H,60,69)(H,61,75)(H,62,76)(H,63,77)(H,64,74)(H,70,71)/t38-,39-,40-,41-,42-,43-/m0/s1

SMILES Code

CC(N[C@H](C(N[C@H]1CCCCNC(CCC(NCCCC[C@@H](C(N[C@H](C(N[C@H](C(N)=O)Cc2ccccc2)=O)CC(O)=O)=O)NC([C@H](Cc3c4ccccc4[nH]c3)NC(CNC1=O)=O)=O)=O)=O)=O)Cc5ccc(O)cc5)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,066.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Witte DG, Nadzan AM, Martinez J, Rodriguez M, Lin CW. Characterization of the novel CCK analogs JMV-180, JMV-320, and JMV-332 in H345 cells. Peptides. 1992 Nov-Dec;13(6):1227-32. PubMed PMID: 1337381. 2: Hadjiivanova C, Kehayov R, Petkov VV, Amblard M, Martinez J. Behavioral effects of the cyclic cholecystokinin peptide analogue JMV-320. Peptides. 1995;16(5):815-9. PubMed PMID: 7479320. 3: Ishizuka J, Martinez J, Townsend CM Jr, Thompson JC. The effect of gastrin on growth of human stomach cancer cells. Ann Surg. 1992 May;215(5):528-34. PubMed PMID: 1616389; PubMed Central PMCID: PMC1242491. 4: Lignon MF, Bernad N, Martinez J. Cholecystokinin receptors in cells of the immune system. Ann N Y Acad Sci. 1994 Mar 23;713:334-7. PubMed PMID: 8185180.