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MedKoo Cat#: 565774 | Name: Eeyarestatin 24

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ES24 is a novel potent enhancer of ca2+ leakage, displaying the highest potency on er ca2+ leakage

Chemical Structure

Eeyarestatin 24
Eeyarestatin 24
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 565774

Name: Eeyarestatin 24

CAS#: N/A

Chemical Formula: C15H13N3O4

Exact Mass: 299.0906

Molecular Weight: 299.29

Elemental Analysis: C, 60.20; H, 4.38; N, 14.04; O, 21.38

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
ES24; ES 24; ES-24; Eeyarestatin 24; Eeyarestatin 24; Eeyarestatin -24
IUPAC/Chemical Name
N'-((1E,2E)-3-(5-nitrofuran-2-yl)allylidene)-2-phenylacetohydrazide
InChi Key
OMQVXHFUKUMBES-LVVPDBGKSA-N
InChi Code
InChI=1S/C15H13N3O4/c19-14(11-12-5-2-1-3-6-12)17-16-10-4-7-13-8-9-15(22-13)18(20)21/h1-10H,11H2,(H,17,19)/b7-4+,16-10+
SMILES Code
O=C(N/N=C/C=C/C1=CC=C([N+]([O-])=O)O1)CC2=CC=CC=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 299.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Akao T. Hasty effect on the metabolism of glycyrrhizin by Eubacterium sp. GLH with Ruminococcus sp. PO1-3 and Clostridium innocuum ES24-06 of human intestinal bacteria. Biol Pharm Bull. 2000 Jan;23(1):6-11. PubMed PMID: 10706402. 2: Li X, Du A, Cai W, Hou Y, Pang L, Gao X. Evaluation of a recombinant excretory secretory Haemonchus contortus protein for use in a diagnostic enzyme-linked immunosorbent assay. Exp Parasitol. 2007 Mar;115(3):242-6. Epub 2006 Oct 27. PubMed PMID: 17069805. 3: Gamayun I, O'Keefe S, Pick T, Klein MC, Nguyen D, McKibbin C, Piacenti M, Williams HM, Flitsch SL, Whitehead RC, Swanton E, Helms V, High S, Zimmermann R, Cavalié A. Eeyarestatin Compounds Selectively Enhance Sec61-Mediated Ca(2+) Leakage from the Endoplasmic Reticulum. Cell Chem Biol. 2019 Apr 18;26(4):571-583.e6. doi: 10.1016/j.chembiol.2019.01.010. Epub 2019 Feb 21. PubMed PMID: 30799222; PubMed Central PMCID: PMC6483976. 4: Zhao J, Zhang C, Lu J, Lu Z. Enhancement of fengycin production in Bacillus amyloliquefaciens by genome shuffling and relative gene expression analysis using RT-PCR. Can J Microbiol. 2016 May;62(5):431-6. doi: 10.1139/cjm-2015-0734. Epub 2016 Feb 9. PubMed PMID: 27035066. 5: Zhao J, Zhang C, Lu Z. Differential proteomics research of Bacillus amyloliquefaciens and its genome-shuffled saltant for improving fengycin production. Braz J Microbiol. 2018 Nov;49 Suppl 1:166-177. doi: 10.1016/j.bjm.2018.04.010. Epub 2018 May 19. PubMed PMID: 29898867; PubMed Central PMCID: PMC6328713. 6: Szabó D, Melan MA, Hujer AM, Bonomo RA, Hujer KM, Bethel CR, Kristóf K, Paterson DL. Molecular analysis of the simultaneous production of two SHV-type extended-spectrum beta-lactamases in a clinical isolate of Enterobacter cloacae by using single-nucleotide polymorphism genotyping. Antimicrob Agents Chemother. 2005 Nov;49(11):4716-20. PubMed PMID: 16251316; PubMed Central PMCID: PMC1280125. 7: Zhao J, Li Y, Zhang C, Yao Z, Zhang L, Bie X, Lu F, Lu Z. Genome shuffling of Bacillus amyloliquefaciens for improving antimicrobial lipopeptide production and an analysis of relative gene expression using FQ RT-PCR. J Ind Microbiol Biotechnol. 2012 Jun;39(6):889-96. doi: 10.1007/s10295-012-1098-9. Epub 2012 Feb 17. PubMed PMID: 22350068. 8: Zhao J, Cao L, Zhang C, Zhong L, Lu J, Lu Z. Differential proteomics analysis of Bacillus amyloliquefaciens and its genome-shuffled mutant for improving surfactin production. Int J Mol Sci. 2014 Oct 31;15(11):19847-69. doi: 10.3390/ijms151119847. PubMed PMID: 25365175; PubMed Central PMCID: PMC4264142. 9: Berning W, de Looze SM, von Deimling O. Identification and development of a genetically closely-linked carboxylesterase family of the mouse liver. Comp Biochem Physiol B. 1985;80(4):859-65. PubMed PMID: 3995927.

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