Fluorescein lisicol | CAS#140616-46-2 | fluorescent-labelled bile salt

MedKoo Cat#: 597587 | Name: Fluorescein lisicol

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fluorescein lisicol is a fluorescent-labelled bile salt, an investigational marker of hepatic biliary transporter function.

Chemical Structure

Fluorescein lisicol

CAS#140616-46-2 (free acid)

Theoretical Analysis

MedKoo Cat#: 597587

Name: Fluorescein lisicol

CAS#: 140616-46-2 (free acid)

Chemical Formula: C51H63N3O11S

Exact Mass: 925.4183

Molecular Weight: 926.13

Elemental Analysis: C, 66.14; H, 6.86; N, 4.54; O, 19.00; S, 3.46

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

397841-88-2 (trisodium) 140616-46-2 (free acid)

Synonym

Fluorescein lisicol; Cholyl-lysl-fluorescein; fluoresceina lisicol; fluoresceine lisicol; fluoresceinum lisicolum; NRL972; NRL 972; NRL-972;

IUPAC/Chemical Name

N6-((3',6'-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthen]-5-yl)carbamothioyl)-N2-((R)-4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoyl)-L-lysine

InChi Key

KHNJPPGHIWPDLG-DXNXUNFASA-N

InChi Code

InChI=1S/C51H63N3O11S/c1-26(33-14-15-37-45-38(25-43(59)50(33,37)3)49(2)18-17-31(57)20-27(49)21-40(45)58)7-16-44(60)54-39(46(61)62)6-4-5-19-52-48(66)53-28-8-11-34-32(22-28)47(63)65-51(34)35-12-9-29(55)23-41(35)64-42-24-30(56)10-13-36(42)51/h8-13,22-24,26-27,31,33,37-40,43,45,55-59H,4-7,14-21,25H2,1-3H3,(H,54,60)(H,61,62)(H2,52,53,66)/t26-,27+,31-,33-,37+,38+,39+,40-,43+,45+,49+,50-/m1/s1

SMILES Code

O=C(O)[C@H](CCCCNC(NC1=CC2=C(C3(C4=C(OC5=C3C=CC(O)=C5)C=C(O)C=C4)OC2=O)C=C1)=S)NC(CC[C@@H](C)[C@H]6CC[C@@]7([H])[C@]8([H])[C@H](O)C[C@]9([H])C[C@H](O)CC[C@]9(C)[C@@]8([H])C[C@H](O)[C@]67C)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 926.13 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: de Mey C, Gatchev E, Deliyska B. Effects of renal insufficiency on the elimination of fluorescein lisicol (NRL972), an investigational marker of hepatic transporter function. Int J Clin Pharmacol Ther. 2015 Jul;53(7):523-30. doi: 10.5414/CP202280. PubMed PMID: 25997548. 2: Bayes M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2004 Sep;26(7):587-612. Review. PubMed PMID: 15538546.