MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 592062 | Name: Conidendrin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Conidendrin is a phenyl-naphthyl-furanolactone.

Chemical Structure

Conidendrin
Conidendrin
CAS#518-55-8

Theoretical Analysis

MedKoo Cat#: 592062

Name: Conidendrin

CAS#: 518-55-8

Chemical Formula: C20H20O6

Exact Mass: 356.1260

Molecular Weight: 356.37

Elemental Analysis: C, 67.41; H, 5.66; O, 26.94

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Conidendrin; NSC 642786; NSC-642786; NSC642786
IUPAC/Chemical Name
Naphtho(2,3-c)furan-1(3H)-one, 3a,4,9,9a-tetrahydro-6-hydroxy-4-(4-hydroxy-3-methoxyphenyl)-7-methoxy-, (3aR-(3aalpha,4alpha,9abeta))- (9CI)
InChi Key
CAYMSCGTKZIVTN-TYILLQQXSA-N
InChi Code
InChI=1S/C20H20O6/c1-24-17-6-10(3-4-15(17)21)19-12-8-16(22)18(25-2)7-11(12)5-13-14(19)9-26-20(13)23/h3-4,6-8,13-14,19,21-22H,5,9H2,1-2H3/t13-,14+,19+/m1/s1
SMILES Code
O=C1OC[C@@]2([H])[C@@]1([H])CC3=C(C=C(O)C(OC)=C3)[C@@H]2C4=CC=C(O)C(OC)=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 356.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Moraux T, Dumarçay S, Gérardin P, Gérardin-Charbonnier C. Derivatives of the Lignan 7'-Hydroxymatairesinol with Antioxidant Properties and Enhanced Lipophilicity. J Nat Prod. 2017 Jun 23;80(6):1783-1790. doi: 10.1021/acs.jnatprod.6b01124. Epub 2017 Jun 7. PubMed PMID: 28590734. 2: Hu CL, Xiong J, Xu P, Cheng KJ, Yang GX, Hu JF. Lignans from the shed trunk barks of the critically endangered plant Abies beshanzuensis and their anti-neuroinflammatory activities. Nat Prod Res. 2017 Jun;31(12):1358-1364. doi: 10.1080/14786419.2016.1247082. Epub 2016 Oct 23. PubMed PMID: 27774796. 3: Sandberg T, Eklund P, Hotokka M. Conformational solvation studies of LIGNOLs with molecular dynamics and conductor-like screening model. Int J Mol Sci. 2012;13(8):9845-63. doi: 10.3390/ijms13089845. Epub 2012 Aug 7. PubMed PMID: 22949834; PubMed Central PMCID: PMC3431832. 4: Tezuka Y, Morikawa K, Li F, Auw L, Awale S, Nobukawa T, Kadota S. Cytochrome P450 3A4 inhibitory constituents of the wood of Taxus yunnanensis. J Nat Prod. 2011 Jan 28;74(1):102-5. doi: 10.1021/np100665j. Epub 2010 Dec 7. PubMed PMID: 21138310. 5: Hu Y, Qu Y, Wu F, Gui J, Wei Y, Hu Q, Wang S. Tuned C-H functionalization to construct aza-podophyllotoxin/aza-conidendrin derivatives by means of domino cyclization. Chem Asian J. 2010 Feb 1;5(2):309-14. doi: 10.1002/asia.200900307. PubMed PMID: 20041457. 6: Smeds AI, Saarinen NM, Eklund PC, Sjöholm RE, Mäkelä SI. New lignan metabolites in rat urine. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Feb 25;816(1-2):87-97. PubMed PMID: 15664338. 7: LaLonde RT, Zhang M. Alpha-conidendrin as a source for preparation of sikkimotoxin derivatives. J Nat Prod. 2004 Apr;67(4):697-9. PubMed PMID: 15104508. 8: Fischer J, Reynolds AJ, Sharp LA, Sherburn MS. Radical carboxyarylation approach to lignans. Total synthesis of (-)-arctigenin, (-)-matairesinol, and related natural products. Org Lett. 2004 Apr 29;6(9):1345-8. PubMed PMID: 15101738. 9: Smeds A, Hakala K. Liquid chromatographic-tandem mass spectrometric method for the plant lignan 7-hydroxymatairesinol and its potential metabolites in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Aug 15;793(2):297-308. PubMed PMID: 12906904. 10: LaLonde RT, Ramdayal F, Sarko A, Yanai K, Zhang M. Modes of methyleneoxy bridging and their effect on tetrahydronaphthalene lignan cytotoxicity. J Med Chem. 2003 Mar 27;46(7):1180-90. PubMed PMID: 12646028. 11: Dantzig A, LaLonde RT, Ramdayal F, Shepard RL, Yanai K, Zhang M. Cytotoxic responses to aromatic ring and configurational variations in alpha-conidendrin, podophyllotoxin, and sikkimotoxin derivatives. J Med Chem. 2001 Jan 18;44(2):180-5. PubMed PMID: 11170627. 12: Toms A, Wood JM. Early intermediates in the degradation of alpha-conidendrin by a Pseudomonas multivorans. Biochemistry. 1970 Feb 17;9(4):733-40. PubMed PMID: 5417393. 13: SUNDMAN V. THE ABILITY OF ALPHA-CONIDENDRIN-DECOMPOSING AGROBACTERIUM STRAINS TO UTILIZE OTHER LIGNANS AND LIGNIN-RELATED COMPOUNDS. J Gen Microbiol. 1964 Aug;36:185-201. PubMed PMID: 14195642. 14: TABAK HH, CHAMBERS CW, KABLER PW. Bacterial utilization of lignans. I. Metabolism of alpha-conidendrin. J Bacteriol. 1959 Oct;78:469-76. PubMed PMID: 13836505; PubMed Central PMCID: PMC290571. 15: WILSON RH, COX AJ Jr. Chronic toxicity studies on conidendrins and conidendrols. Proc Soc Exp Biol Med. 1954 Jun;86(2):247-50. PubMed PMID: 13177643. 16: PRATT YT, KONETZKA WA, PELCZAR MJ Jr, MARTIN WH. Biological degradation of lignin. V. Polysaccharide synthesis from alpha-conidendrin. Appl Microbiol. 1953 Jul;1(4):171-4. PubMed PMID: 13066027; PubMed Central PMCID: PMC1056897. 17: KONETZKA WA, PELCZAR MJ Jr, GOTTLIEB S. The biological degradation of lignin. III. Bacterial degradation of alpha-conidendrin. J Bacteriol. 1952 Jun;63(6):771-8. PubMed PMID: 14938339; PubMed Central PMCID: PMC169627.

View History

Concanavalin A

Concanavalin A

Leramistat

Leramistat

Lepalone

Lepalone