MedKoo Cat#: 527830 | Name: Ditran

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ditran is an anticholinergic agent, blocking end-plate ion conductance; Psychodysleptic agent.

Chemical Structure

Ditran
Ditran
CAS#8015-54-1

Theoretical Analysis

MedKoo Cat#: 527830

Name: Ditran

CAS#: 8015-54-1

Chemical Formula: C21H25NO3

Exact Mass: 339.1834

Molecular Weight: 339.44

Elemental Analysis: C, 74.31; H, 7.42; N, 4.13; O, 14.14

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Ditran
IUPAC/Chemical Name
(1-Ethylpiperidin-3-yl) 2-hydroxy-2,2-diphenylacetate
InChi Key
OJYOTLHNSMYONM-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H25NO3/c1-2-22-15-9-14-19(16-22)25-20(23)21(24,17-10-5-3-6-11-17)18-12-7-4-8-13-18/h3-8,10-13,19,24H,2,9,14-16H2,1H3
SMILES Code
O=C(OC1CN(CC)CCC1)C(C2=CC=CC=C2)(O)C3=CC=CC=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 339.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Gaillard Y, Regenstreif P, Fanton L. Modern toxic antipersonnel projectiles. Am J Forensic Med Pathol. 2014 Dec;35(4):258-64. doi: 10.1097/PAF.0b013e318288abe8. PubMed PMID: 25354227. 2: Vanderwolf CH, Stewart DJ. Joint cholinergic-serotonergic control of neocortical and hippocampal electrical activity in relation to behavior: effects of scopolamine, ditran, trifluoperazine and amphetamine. Physiol Behav. 1986;38(1):57-65. PubMed PMID: 3786502. 3: Volle RL, Alkadhi KA, Branisteanu DD, Reynolds LS, Epstein PM, Smilowitz H, Lambert JJ, Henderson EG. Ketamine and ditran block end-plate ion conductance and [3H]phencyclidine binding to electric organ membrane. J Pharmacol Exp Ther. 1982 Jun;221(3):570-6. PubMed PMID: 6123584. 4: Korol B, Yaffe GJ, Biddy RL, Bidus DR. A behavioral and autonomic nervous system study of chronic imipramine administration to conscious dogs. Pharmacology. 1978;16(2):61-9. PubMed PMID: 619365. 5: Bouyer JJ, Dedet L, Verdeaux J, Rougeul A. Selective modification of spontaneous ECoG rhythms of the cat somesthetic cortex by psychoactive drugs: behavioral correlates. Psychopharmacology (Berl). 1977 Dec 28;55(3):237-42. PubMed PMID: 414284. 6: Overton DA. Discriminable effects of antimuscarinics: dose response and substitution test studies. Pharmacol Biochem Behav. 1977 Jun;6(6):659-66. PubMed PMID: 263548. 7: Järbe TU, Johansson JO. Drug discrimination in rats: effects of mixtures of ditran and cholinesterase inhibitors. Pharmacol Biochem Behav. 1976 Feb;4(2):151-7. PubMed PMID: 1265102. 8: Johansson JO, Järbe TU. Physostigmine as a discriminative cue in rats. Arch Int Pharmacodyn Ther. 1976 Jan;219(1):97-102. PubMed PMID: 1267546. 9: Henriksson BG, Johansson JO, Järbe TU. Delta 9-tetrahydrocannabinol produced discrimination in pigeons. Pharmacol Biochem Behav. 1975 Sep-Oct;3(5):771-4. PubMed PMID: 1208619. 10: Järbe TU, Johansson JO, Henriksson BG. Drug discrimination in rats: the effects of phencyclidine and ditran. Psychopharmacologia. 1975 Apr 30;42(1):33-9. PubMed PMID: 125431. 11: Angrist B, Urcuyo L, Gershon S. Response to incremental doses of Ditran in abstinent alcoholics and drug users. Compr Psychiatry. 1974 May-Jun;15(3):201-4. PubMed PMID: 4596770. 12: Ketchum JS, Sidell FR, Crowell EB Jr, Aghajanian GK, Hayes AH Jr. Atropine, scopolamine, and ditran: comparative pharmacology and antagonists in man. Psychopharmacologia. 1973 Jan 1;28(2):121-45. PubMed PMID: 4694622. 13: Demchenko VM, Vorob'eva NA. [Effect of ditran on the catecholamine content in the brain and adrenal glands in cats]. Farmakol Toksikol. 1971 May-Jun;34(3):272-5. Russian. PubMed PMID: 5568683. 14: Panov PA. [An electroencephalographic analysis of an experimental psychosis induced by ditran]. Zh Nevropatol Psikhiatr Im S S Korsakova. 1970;70(2):261-4. Russian. PubMed PMID: 5462190. 15: Karadzić V, Veskov R. The effect of JB-329 (Ditran) on sleep in the cat. Electroencephalogr Clin Neurophysiol. 1969 Nov;27(5):554. PubMed PMID: 4187081. 16: Itil TM, Keskiner S, Holden JM. The use of LSD and ditran in the treatment of therapy resistant schizophrenics (symptom provocation approach). Dis Nerv Syst. 1969 Feb;30(2):Suppl:93-103. PubMed PMID: 4388281. 17: Baryshnikov II, Blagovidoca LL, Mil'shteĭn GI. [To the pharmacology of ditran]. Farmakol Toksikol. 1968 Jul-Aug;31(4):434-6. Russian. PubMed PMID: 5725213. 18: Cohen M, Wakeley H. A comparative behavioral study of ditran and LSD in mice, rats, and dogs. Arch Int Pharmacodyn Ther. 1968 Jun;173(2):316-26. PubMed PMID: 5684262. 19: Pradhan SN, Beer B, Roth T, Dutta SN. Some behavioral effects of Ditran (JB 329) in rats. Arch Int Pharmacodyn Ther. 1967 Dec;170(2):264-75. PubMed PMID: 6076580. 20: Giovannucci M, Marforio S, Morlotti PA. [Clinical and polygraphic study of a drug with psychodysleptic properties: Ditran]. Riv Sper Freniatr Med Leg Alien Ment. 1967 Apr 3;91(2):555-68. Italian. PubMed PMID: 6081348.