INDY | CAS#1169755-45-6 | Dyrk1A inhibitor

MedKoo Cat#: 558366 | Name: INDY

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

INDY is a potent ATP-competitive Dyrk1A inhibitor.

Chemical Structure

INDY

CAS#1169755-45-6

Theoretical Analysis

MedKoo Cat#: 558366

Name: INDY

CAS#: 1169755-45-6

Chemical Formula: C12H13NO2S

Exact Mass: 235.0700

Molecular Weight: 235.30

Elemental Analysis: C, 61.25; H, 5.57; N, 5.95; O, 13.60; S, 13.63

Price and Availability

Size	Price	Availability
100mg	USD 750.00	2 Weeks
200mg	USD 1,250.00	2 Weeks
500mg	USD 2,450.00	2 Weeks
1g	USD 3,650.00	2 Weeks

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Related CAS #

1169755-45-6

Synonym

INDY;

IUPAC/Chemical Name

(1Z)-1-(3-ethyl-5-hydroxy-1,3-benzothiazol-2(3H)-ylidene)-2-propanone

InChi Key

GCSZJMUFYOAHFY-SDQBBNPISA-N

InChi Code

InChI=1S/C12H13NO2S/c1-3-13-10-7-9(15)4-5-11(10)16-12(13)6-8(2)14/h4-7,15H,3H2,1-2H3/b12-6-

SMILES Code

CC(/C=C1SC2=CC=C(O)C=C2N\1CC)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 235.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Rogers RP, Rogina B. The role of INDY in metabolism, health and longevity. Front Genet. 2015 Jun 9;6:204. doi: 10.3389/fgene.2015.00204. eCollection 2015. Review. PubMed PMID: 26106407; PubMed Central PMCID: PMC4460575. 2: Schwarz F, Karadeniz Z, Fischer-Rosinsky A, Willmes DM, Spranger J, Birkenfeld AL. Knockdown of Indy/CeNac2 extends Caenorhabditis elegans life span by inducing AMPK/aak-2. Aging (Albany NY). 2015 Aug;7(8):553-67. PubMed PMID: 26318988; PubMed Central PMCID: PMC4586101. 3: Rogers RP, Rogina B. Increased mitochondrial biogenesis preserves intestinal stem cell homeostasis and contributes to longevity in Indy mutant flies. Aging (Albany NY). 2014 Apr;6(4):335-50. PubMed PMID: 24827528; PubMed Central PMCID: PMC4032799. 4: Rogina B, Helfand SL. Indy mutations and Drosophila longevity. Front Genet. 2013 Apr 8;4:47. doi: 10.3389/fgene.2013.00047. eCollection 2013. PubMed PMID: 23580130; PubMed Central PMCID: PMC3619052. 5: Willmes DM, Birkenfeld AL. The Role of INDY in Metabolic Regulation. Comput Struct Biotechnol J. 2013 Dec 8;6:e201303020. doi: 10.5936/csbj.201303020. eCollection 2013. Review. PubMed PMID: 24688728; PubMed Central PMCID: PMC3962103. 6: Birkenfeld AL, Lee HY, Guebre-Egziabher F, Alves TC, Jurczak MJ, Jornayvaz FR, Zhang D, Hsiao JJ, Martin-Montalvo A, Fischer-Rosinsky A, Spranger J, Pfeiffer AF, Jordan J, Fromm MF, König J, Lieske S, Carmean CM, Frederick DW, Weismann D, Knauf F, Irusta PM, De Cabo R, Helfand SL, Samuel VT, Shulman GI. Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice. Cell Metab. 2011 Aug 3;14(2):184-95. doi: 10.1016/j.cmet.2011.06.009. Erratum in: Cell Metab. 2011 Oct 5;14(4):567. PubMed PMID: 21803289; PubMed Central PMCID: PMC3163140. 7: Zhu CT, Chang C, Reenan RA, Helfand SL. Indy gene variation in natural populations confers fitness advantage and life span extension through transposon insertion. Aging (Albany NY). 2014 Jan;6(1):58-69. PubMed PMID: 24519859; PubMed Central PMCID: PMC3927810. 8: Frankel S, Rogina B. Indy mutants: live long and prosper. Front Genet. 2012 Feb 17;3:13. doi: 10.3389/fgene.2012.00013. eCollection 2012. PubMed PMID: 22363340; PubMed Central PMCID: PMC3281209. 9: Neuschäfer-Rube F, Lieske S, Kuna M, Henkel J, Perry RJ, Erion DM, Pesta D, Willmes DM, Brachs S, von Loeffelholz C, Tolkachov A, Schupp M, Pathe-Neuschäfer-Rube A, Pfeiffer AF, Shulman GI, Püschel GP, Birkenfeld AL. The mammalian INDY homolog is induced by CREB in a rat model of type 2 diabetes. Diabetes. 2014 Mar;63(3):1048-57. doi: 10.2337/db13-0749. Epub 2013 Nov 12. PubMed PMID: 24222346; PubMed Central PMCID: PMC3968437. 10: Neretti N, Wang PY, Brodsky AS, Nyguyen HH, White KP, Rogina B, Helfand SL. Long-lived Indy induces reduced mitochondrial reactive oxygen species production and oxidative damage. Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2277-82. doi: 10.1073/pnas.0812484106. Epub 2009 Jan 21. PubMed PMID: 19164521; PubMed Central PMCID: PMC2629441. 11: Wang PY, Neretti N, Whitaker R, Hosier S, Chang C, Lu D, Rogina B, Helfand SL. Long-lived Indy and calorie restriction interact to extend life span. Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9262-7. doi: 10.1073/pnas.0904115106. Epub 2009 May 22. PubMed PMID: 19470468; PubMed Central PMCID: PMC2685744. 12: Toivonen JM, Walker GA, Martinez-Diaz P, Bjedov I, Driege Y, Jacobs HT, Gems D, Partridge L. No influence of Indy on lifespan in Drosophila after correction for genetic and cytoplasmic background effects. PLoS Genet. 2007 Jun;3(6):e95. Epub 2007 Apr 30. PubMed PMID: 17571923; PubMed Central PMCID: PMC1892600. 13: Inoue K, Fei YJ, Huang W, Zhuang L, Chen Z, Ganapathy V. Functional identity of Drosophila melanogaster Indy as a cation-independent, electroneutral transporter for tricarboxylic acid-cycle intermediates. Biochem J. 2002 Oct 15;367(Pt 2):313-9. PubMed PMID: 12186628; PubMed Central PMCID: PMC1222911. 14: Knauf F, Rogina B, Jiang Z, Aronson PS, Helfand SL. Functional characterization and immunolocalization of the transporter encoded by the life-extending gene Indy. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14315-9. Epub 2002 Oct 21. PubMed PMID: 12391301; PubMed Central PMCID: PMC137881. 15: Knauf F, Mohebbi N, Teichert C, Herold D, Rogina B, Helfand S, Gollasch M, Luft FC, Aronson PS. The life-extending gene Indy encodes an exchanger for Krebs-cycle intermediates. Biochem J. 2006 Jul 1;397(1):25-9. PubMed PMID: 16608441; PubMed Central PMCID: PMC1479758. 16: Kaur H, Jaso-Friedmann L, Leary JH 3rd, Praveen K, Brahmi Z, Evans DL. Activation of natural killer-like YT-INDY cells by oligodeoxynucleotides and binding by homologous pattern recognition proteins. Scand J Immunol. 2005 Oct;62(4):361-70. PubMed PMID: 16253123. 17: Tarazona R, Borrego F, Galiani MD, Aguado E, Peña J, Coligan JE, Solana R. Inhibition of CD28-mediated natural cytotoxicity by KIR2DL2 does not require p56(lck) in the NK cell line YT-Indy. Mol Immunol. 2002 Jan;38(7):495-503. PubMed PMID: 11750651. 18: Fain JA. Join Us in Indy for AADE's 39th Annual Meeting and Exhibition. Diabetes Educ. 2012 Jul-Aug;38(4):455. doi: 10.1177/0145721712452842. PubMed PMID: 22814715. 19: Shulman GI, Helfand SL. Indy knockdown in mice mimics elements of dietary restriction. Aging (Albany NY). 2011 Aug;3(8):701. PubMed PMID: 21937764; PubMed Central PMCID: PMC3184973. 20: Melvin JW, Begeman PC, Faller RK, Sicking DL, McClellan SB, Maynard E, Donegan MW, Mallott AM, Gideon TW. Crash protection of stock car racing drivers--application of biomechanical analysis of Indy car crash research. Stapp Car Crash J. 2006 Nov;50:415-28. Review. PubMed PMID: 17311172.