Synonym
Enkephalin-met, lys(6)-; Met-enk-L; 6-Lys-met-enkephalin;
IUPAC/Chemical Name
L-tyrosylglycylglycyl-L-phenylalanyl-L-methionyl-L-lysine
InChi Key
CFOVZGFKVVQYMH-FWEHEUNISA-N
InChi Code
InChI=1S/C33H47N7O8S/c1-49-16-14-25(31(45)40-26(33(47)48)9-5-6-15-34)39-32(46)27(18-21-7-3-2-4-8-21)38-29(43)20-36-28(42)19-37-30(44)24(35)17-22-10-12-23(41)13-11-22/h2-4,7-8,10-13,24-27,41H,5-6,9,14-20,34-35H2,1H3,(H,36,42)(H,37,44)(H,38,43)(H,39,46)(H,40,45)(H,47,48)/t24-,25-,26-,27-/m0/s1
SMILES Code
NCCCC[C@@H](C(O)=O)NC([C@H](CCSC)NC([C@H](CC1=CC=CC=C1)NC(CNC(CNC([C@H](CC2=CC=C(O)C=C2)N)=O)=O)=O)=O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
701.84
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Rossier J, Dean DM, Livett BG, Udenfriend S. Enkephalin congeners and precursors are synthesized and released by primary cultures of adrenal chromaffin cells. Life Sci. 1981 Feb 16;28(7):781-9. PubMed PMID: 7231054.
2: Bergström L, Lagercrantz H, Terenius L. Post-mortem analyses of neuropeptides in brains from sudden infant death victims. Brain Res. 1984 Dec 10;323(2):279-85. PubMed PMID: 6084539.
3: Nicholson LM, Patel HB, Kristjansson F, Crowley SC Jr, Dave K, Stobaugh JF, Riley CM. Multidimensional liquid chromatography of opioid peptides: fluorogenic labelling, retention prediction and separation optimization. J Pharm Biomed Anal. 1990;8(8-12):805-16. PubMed PMID: 2100627.
4: Stern AS, Lewis RV, Kimura S, Rossier J, Stein S, Udenfriend S. Opioid hexapeptides and heptapeptides in adrenal medulla and brain possible implications on the biosynthesis of enkephalins. Arch Biochem Biophys. 1980 Dec;205(2):606-13. PubMed PMID: 6258484.
5: Williams RG, Dockray GJ. Differential distribution in rat basal ganglia of Met-enkephalin- and Met-enkephalin Arg6 Phe7-like peptides revealed by immunohistochemistry. Brain Res. 1982 May 20;240(1):167-70. PubMed PMID: 7046877.
