N 556 | CAS#110816-78-9 | disodium cromoglycate prodrug

MedKoo Cat#: 597508 | Name: N 556

Description:

WARNING: This product is for research use only, not for human or veterinary use.

N 556 is a prodrug for disodium cromoglycate.

Chemical Structure

N 556

CAS#110816-78-9

Theoretical Analysis

MedKoo Cat#: 597508

Name: N 556

CAS#: 110816-78-9

Chemical Formula: C33H38Cl2N2O12

Exact Mass:

Molecular Weight: 725.56

Elemental Analysis: C, 54.63; H, 5.28; Cl, 9.77; N, 3.86; O, 26.46

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

N 556; N-556; N556; KY-556; KY556;

IUPAC/Chemical Name

diethyl 5,5'-((2-((2,6-diaminohexanoyl)oxy)propane-1,3-diyl)bis(oxy))(S)-bis(4-oxo-4H-chromene-2-carboxylate) dihydrochloride

InChi Key

VZZTWOVKCVPTSM-FJSYBICCSA-N

InChi Code

InChI=1S/C33H36N2O12.2ClH/c1-3-41-32(39)27-15-21(36)29-23(10-7-12-25(29)46-27)43-17-19(45-31(38)20(35)9-5-6-14-34)18-44-24-11-8-13-26-30(24)22(37)16-28(47-26)33(40)42-4-2;;/h7-8,10-13,15-16,19-20H,3-6,9,14,17-18,34-35H2,1-2H3;2*1H/t20-;;/m0../s1

SMILES Code

N[C@@H](CCCCN)C(OC(COC1=C2C(C=C(C(OCC)=O)OC2=CC=C1)=O)COC3=C4C(C=C(C(OCC)=O)OC4=CC=C3)=O)=O.[H]Cl.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 725.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Yoshimi A, Hashizume H, Kitagawa M, Nishimura K, Kakeya N. Absorption mechanism of 1,3-bis(2-ethoxycarbonylchromon-5-yloxy)-2-((S)-lysyloxy )propane dihydrochloride (N-556), a prodrug for the oral delivery of disodium cromoglycate. Biol Pharm Bull. 1993 Apr;16(4):375-8. PubMed PMID: 8358388. 2: Yoshimi A, Hashizume H, Kitagawa M, Nishimura K, Kakeya N. Characteristics of 1,3-bis-(2-ethoxycarbonylchromon-5-yloxy)-2-((S)- lysyloxy)propane dihydrochloride (N-556), a prodrug for the oral delivery of disodium cromoglycate, in absorption and excretion in rats and rabbits. J Pharmacobiodyn. 1992 Dec;15(12):681-6. PubMed PMID: 1296978. 3: Nakamura S, Yamamura H, Kohno S, Ohata K, Yoshimi A, Nishimura K, Kakeya N. Effects of N-556 on experimental allergy models in rats. Arerugi. 1990 Dec;39(12):1621-8. PubMed PMID: 2096808. 4: Nagai H, Yamaguchi S, Maeda Y, Tanaka H. Role of mast cells, eosinophils and IL-5 in the development of airway hyperresponsiveness in sensitized mice. Clin Exp Allergy. 1996 Jun;26(6):642-7. PubMed PMID: 8809421.