Synonym
CPR3; CPR-3; CPR 3
IUPAC/Chemical Name
2-(2,6-dioxopiperidin-3-yl)-4-((2-(2-(4-((4-((5-methyl-1H-pyrazol-3-yl)amino)pyrimidin-2-yl)amino)phenoxy)ethoxy)ethyl)amino)isoindoline-1,3-dione
InChi Key
YEBGDZYCAZJQHH-UHFFFAOYSA-N
InChi Code
InChI=1S/C31H31N9O6/c1-18-17-25(39-38-18)35-24-11-12-33-31(36-24)34-19-5-7-20(8-6-19)46-16-15-45-14-13-32-22-4-2-3-21-27(22)30(44)40(29(21)43)23-9-10-26(41)37-28(23)42/h2-8,11-12,17,23,32H,9-10,13-16H2,1H3,(H,37,41,42)(H3,33,34,35,36,38,39)
SMILES Code
CC1=CC(NC2=CC=NC(NC3=CC=C(OCCOCCNC4=CC=CC(C(N5C6CCC(NC6=O)=O)=O)=C4C5=O)C=C3)=N2)=NN1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
625.65
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Shukla VK, Singh JS, Trivedi D, Hosur RV, Kumar A. NMR assignments of
mitochondrial cyclophilin Cpr3 from Saccharomyces cerevisiae. Biomol NMR Assign.
2016 Apr;10(1):203-6. doi: 10.1007/s12104-016-9667-x. Epub 2016 Feb 20. PMID:
26897529.
2: Koushi M, Asakai R. Bisindolylpyrrole Induces a Cpr3- and Porin1/2-Dependent
Transition in Yeast Mitochondrial Permeability in a Low Conductance State via
the AACs-Associated Pore. Int J Mol Sci. 2021 Jan 26;22(3):1212. doi:
10.3390/ijms22031212. PMID: 33530556; PMCID: PMC7865566.
3: Shukla VK, Singh JS, Vispute N, Ahmad B, Kumar A, Hosur RV. Unfolding of CPR3
Gets Initiated at the Active Site and Proceeds via Two Intermediates. Biophys J.
2017 Feb 28;112(4):605-619. doi: 10.1016/j.bpj.2016.12.020. PMID: 28256221;
PMCID: PMC5340121.
4: Tadema H, Kallenberg CG, Stegeman CA, Heeringa P. Reactivity against
complementary proteinase-3 is not increased in patients with PR3-ANCA-associated
vasculitis. PLoS One. 2011 Mar 17;6(3):e17972. doi:
10.1371/journal.pone.0017972. PMID: 21437233; PMCID: PMC3060099.
5: Yang J, Bautz DJ, Lionaki S, Hogan SL, Chin H, Tisch RM, Schmitz JL, Pressler
BM, Jennette JC, Falk RJ, Preston GA. ANCA patients have T cells responsive to
complementary PR-3 antigen. Kidney Int. 2008 Nov;74(9):1159-69. doi:
10.1038/ki.2008.309. Epub 2008 Jul 2. PMID: 18596726; PMCID: PMC2754720.
6: Kamei Y, Koushi M, Aoyama Y, Asakai R. The yeast mitochondrial permeability
transition is regulated by reactive oxygen species, endogenous Ca2+
and Cpr3, mediating cell death. Biochim Biophys Acta Bioenerg. 2018
Dec;1859(12):1313-1326. doi: 10.1016/j.bbabio.2018.07.004. Epub 2018 Jul 20.
PMID: 30031690.
