Synonym
Phenylalanylleucine; L-Phenylalanyl-L-leucine; Phe-leu;
IUPAC/Chemical Name
L-phenylalanyl-L-leucine
InChi Key
RFCVXVPWSPOMFJ-STQMWFEESA-N
InChi Code
InChI=1S/C15H22N2O3/c1-10(2)8-13(15(19)20)17-14(18)12(16)9-11-6-4-3-5-7-11/h3-7,10,12-13H,8-9,16H2,1-2H3,(H,17,18)(H,19,20)/t12-,13-/m0/s1
SMILES Code
CC(C)C[C@@H](C(O)=O)NC([C@H](CC1=CC=CC=C1)N)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Biological target:
L-Phenylalanyl-L-leucine is a leucine derivative.
|
Solvent |
mg/mL |
mM |
comments |
Solubility |
DMSO |
3.9 |
13.83 |
|
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
278.35
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Gómez-Tamayo JC, Cordomí A, Olivella M, Mayol E, Fourmy D, Pardo L. Analysis of the interactions of sulfur-containing amino acids in membrane proteins. Protein Sci. 2016 Aug;25(8):1517-24. doi: 10.1002/pro.2955. Epub 2016 Jun 8. PubMed PMID: 27240306; PubMed Central PMCID: PMC4972207.
2: Andrade SS, Silva MC, Gouvea IE, Kondo MY, Juliano MA, Sampaio MU, Oliva ML. Baupain, a plant cysteine proteinase that hinders thrombin-induced human platelet aggregation. Protein Pept Lett. 2012 Apr;19(4):474-7. PubMed PMID: 22185503.
3: Gollop N, Tavori H, Barak Z. Acetohydroxy acid synthase is a target for leucine containing peptide toxicity in Escherichia coli. J Bacteriol. 1982 Jan;149(1):387-90. PubMed PMID: 7033214; PubMed Central PMCID: PMC216639.
4: Beaumont A, Roques BP. Presence of a histidine at the active site of the neutral endopeptidase-24.11. Biochem Biophys Res Commun. 1986 Sep 14;139(2):733-9. PubMed PMID: 3533067.
5: Porras O, Caugant DA, Lagergård T, Svanborg-Edén C. Application of multilocus enzyme gel electrophoresis to Haemophilus influenzae. Infect Immun. 1986 Jul;53(1):71-8. PubMed PMID: 3522433; PubMed Central PMCID: PMC260077.
6: Noguerola AS, Murugaverl B, Voorhees KJ. An investigation of dipeptides containing polar and nonpolar side groups by curie-point pyrolysis tandem mass spectrometry. J Am Soc Mass Spectrom. 1992 Oct;3(7):750-6. doi: 10.1016/1044-0305(92)87088-G. PubMed PMID: 24234642.
7: Akhiani AA, Nilsson LA, Ouchterlony O. Comparative antigen analysis of different life stages of Schistosoma mansoni by crossed immunoelectrophoresis. Int Arch Allergy Appl Immunol. 1991;95(2-3):266-72. PubMed PMID: 1937928.