Ditiocarb sodium | CAS#148-18-5 |

MedKoo Cat#: 591905 | Name: Ditiocarb sodium

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ditiocarb sodium is a chelating agent that has been used to mobilize toxic metals from the tissues of man and experimental animals. It is the main metabolite of DISULFIRAM.

Chemical Structure

Ditiocarb sodium

CAS#148-18-5 (sodium)

Theoretical Analysis

MedKoo Cat#: 591905

Name: Ditiocarb sodium

CAS#: 148-18-5 (sodium)

Chemical Formula: C5H10NNaS2

Exact Mass: 0.0000

Molecular Weight: 171.25

Elemental Analysis: C, 35.07; H, 5.89; N, 8.18; Na, 13.42; S, 37.44

Price and Availability

Size	Price	Availability	Quantity
5g	USD 350.00	2 Weeks
25g	USD 650.00	2 Weeks

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Related CAS #

148-18-5 (sodium) 147-84-2 (free acid)

Synonym

Ditiocarb sodium; sodium diethyldithiocarbamate; Ditiocarb sodium; Sodium N,N-diethyldithiocarbamate; Sodium diethylcarbamodithioate; NSC 38583; NSC-38583; NSC38583

IUPAC/Chemical Name

Carbamodithioic acid, diethyl-, sodium salt

InChi Key

IOEJYZSZYUROLN-UHFFFAOYSA-M

InChi Code

InChI=1S/C5H11NS2.Na/c1-3-6(4-2)5(7)8;/h3-4H2,1-2H3,(H,7,8);/q;+1/p-1

SMILES Code

[S-]C(N(CC)CC)=S.[Na+]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Ditiocarb sodium (Sodium diethyldithiocarbamate) is an accelerator of the rate of copper cementation.

In vitro activity:

Cell cytotoxicity against 3T3 and RAW cell lines and evaluated by MTT, demonstrated that DETC (diethyldithiocarbamate) in high concentration (2222.00 µM) presents low toxicity. Yet, DETC causes mitochondrial damage in T. cruzi, as well as disruption in parasite membrane. DETC has antiparasitic activity against different genotypes and forms of T. cruzi, therefore, representing a promising molecule as a drug for the treatment of Chagas disease. Reference: Sci Rep. 2021 May 27;11(1):11200. https://pubmed.ncbi.nlm.nih.gov/34045624/

In vivo activity:

In normal rabbits, DTC (diethyldithiocarbamate) did not change the number of neutrophils, but increased their phagocytic activity and ability to reduce NBT. In febrile rabbits, DTC depending on the dose, shortened the stimulating effect of LPS on neutrophil ability to reduce NBT but enhanced and prolonged the effect of pyrogen on neutrophil phagocytic activity. The rabbits treated with DTC prior to hypothermia exhibited shorter neutrophilia resulting from cold stress. In addition, DTC administered to the rabbits before their exposure to cold stress proved to be a partial or even total protection against the decrease in NBT reducing ability and phagocytic activity of blood neutrophils. Reference: Immunopharmacol Immunotoxicol. 1995 Nov;17(4):733-44. https://pubmed.ncbi.nlm.nih.gov/8537609/

	Solvent	mg/mL	mM
Solubility
	DMSO	100.0	583.94

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 171.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. de Freitas Oliveira JW, Torres TM, Moreno CJG, Amorim-Carmo B, Damasceno IZ, Soares AKMC, da Silva Barbosa J, Rocha HAO, Silva MS. Insights of antiparasitic activity of sodium diethyldithiocarbamate against different strains of Trypanosoma cruzi. Sci Rep. 2021 May 27;11(1):11200. doi: 10.1038/s41598-021-90719-0. PMID: 34045624; PMCID: PMC8159965. 2. Rahden-Staroń I, Grosicka-Maciąg E, Kurpios-Piec D, Czeczot H, Grzela T, Szumiło M. The effects of sodium diethyldithiocarbamate in fibroblasts V79 cells in relation to cytotoxicity, antioxidative enzymes, glutathione, and apoptosis. Arch Toxicol. 2012 Dec;86(12):1841-50. doi: 10.1007/s00204-012-0909-0. Epub 2012 Aug 8. PMID: 22872140; PMCID: PMC3496549. 3. Obmińska-Domoradzka B, Debowy J. Modulating effect of sodium diethyldithiocarbamate on neutrophils in normal, febrile and cold-stressed rabbits. Immunopharmacol Immunotoxicol. 1995 Nov;17(4):733-44. doi: 10.3109/08923979509037192. PMID: 8537609. 4. Renoux G, Bizière K, Renoux M, Steinberg R, Kan JP, Guillaumin JM. Sodium diethyldithiocarbamate protects against the MPTP-induced inhibition of immune responses in mice. Life Sci. 1989;44(12):771-7. doi: 10.1016/0024-3205(89)90374-3. PMID: 2539542.

In vitro protocol:

In vivo protocol:

1. Obmińska-Domoradzka B, Debowy J. Modulating effect of sodium diethyldithiocarbamate on neutrophils in normal, febrile and cold-stressed rabbits. Immunopharmacol Immunotoxicol. 1995 Nov;17(4):733-44. doi: 10.3109/08923979509037192. PMID: 8537609. 2. Renoux G, Bizière K, Renoux M, Steinberg R, Kan JP, Guillaumin JM. Sodium diethyldithiocarbamate protects against the MPTP-induced inhibition of immune responses in mice. Life Sci. 1989;44(12):771-7. doi: 10.1016/0024-3205(89)90374-3. PMID: 2539542.

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