MedKoo Cat#: 597326 | Name: Carnosine nitrate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Carnosine nitrate is a dipeptide molecule, made up of the amino acids beta-alanine and histidine. It is highly concentrated in muscle and brain tissues.

Chemical Structure

Carnosine nitrate
Carnosine nitrate
CAS#5852-98-2 (nitrate)

Theoretical Analysis

MedKoo Cat#: 597326

Name: Carnosine nitrate

CAS#: 5852-98-2 (nitrate)

Chemical Formula: C9H15N5O6

Exact Mass: 0.0000

Molecular Weight: 289.24

Elemental Analysis: C, 37.37; H, 5.23; N, 24.21; O, 33.19

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Carnosine nitrate; (+)-Carnosine nitrate;
IUPAC/Chemical Name
(3-aminopropanoyl)-L-histidine compound with nitric acid (1:1)
InChi Key
CPZFLUMGMDPGIE-FJXQXJEOSA-N
InChi Code
InChI=1S/C9H14N4O3.HNO3/c10-2-1-8(14)13-7(9(15)16)3-6-4-11-5-12-6;2-1(3)4/h4-5,7H,1-3,10H2,(H,11,12)(H,13,14)(H,15,16);(H,2,3,4)/t7-;/m0./s1
SMILES Code
O=C(O)[C@H](CC1=CNC=N1)NC(CCN)=O.O[N+]([O-])=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 289.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Cicero AFG, Colletti A. Nutraceuticals and Dietary Supplements to Improve Quality of Life and Outcomes in Heart Failure Patients. Curr Pharm Des. 2017;23(8):1265-1272. doi: 10.2174/1381612823666170124120518. Review. PubMed PMID: 28120718. 2: De Smet S, Van Thienen R, Deldicque L, James R, Sale C, Bishop DJ, Hespel P. Nitrate Intake Promotes Shift in Muscle Fiber Type Composition during Sprint Interval Training in Hypoxia. Front Physiol. 2016 Jun 14;7:233. doi: 10.3389/fphys.2016.00233. eCollection 2016. PubMed PMID: 27378942; PubMed Central PMCID: PMC4906611. 3: Abdelazim SA, Darwish HA, Ali SA, Rizk MZ, Kadry MO. Potential antifibrotic and angiostatic impact of idebenone, carnosine and vitamin E in nano-sized titanium dioxide-induced liver injury. Cell Physiol Biochem. 2015;35(6):2402-11. doi: 10.1159/000374041. Epub 2015 Apr 16. PubMed PMID: 25896716. 4: Yapislar H, Taskin E. L-carnosine alters some hemorheologic and lipid peroxidation parameters in nephrectomized rats. Med Sci Monit. 2014 Mar 11;20:399-405. doi: 10.12659/MSM.890528. PubMed PMID: 24614724; PubMed Central PMCID: PMC3958568. 5: Macià A, Motilva MJ, Romero MP, Labrador A, Domínguez A, Peiro L. Improved liquid-chromatography tandem mass spectrometry method for the determination of the bioactive dipeptides, carnosine and anserine: application to analysis in chicken broth. Talanta. 2012 May 15;93:293-300. doi: 10.1016/j.talanta.2012.02.036. Epub 2012 Feb 23. PubMed PMID: 22483913. 6: Grigor'ev VV, Petrova LN, Ivanova TA, Kotel'nikova RA, Bogdanov GN, Poletaeva DA, Faĭngol'd II, Mishchenko DV, Romanova VS, Kotel'nikov AI, Bachurin SO. [Study of the neuroprotective action of hybrid structures based on fullerene C60]. Izv Akad Nauk Ser Biol. 2011 Mar-Apr;(2):163-70. Russian. PubMed PMID: 21506390. 7: Arnal N, de Alaniz MJ, Marra CA. Carnosine and neocuproine as neutralizing agents for copper overload-induced damages in cultured human cells. Chem Biol Interact. 2011 Jul 15;192(3):257-63. doi: 10.1016/j.cbi.2011.03.017. Epub 2011 Apr 8. PubMed PMID: 21501601. 8: Noori S, Mahboob T. Antioxidant effect of carnosine pretreatment on cisplatin-induced renal oxidative stress in rats. Indian J Clin Biochem. 2010 Jan;25(1):86-91. doi: 10.1007/s12291-010-0018-x. Epub 2010 Feb 10. PubMed PMID: 23105891; PubMed Central PMCID: PMC3453019. 9: Gianelli MP, Flores M, Toldrá F. Interaction of soluble peptides and proteins from skeletal muscle with volatile compounds in model systems as affected by curing agents. J Agric Food Chem. 2005 Mar 9;53(5):1670-7. PubMed PMID: 15740057. 10: Yamashita T, Shimada S, Guo W, Sato K, Kohmura E, Hayakawa T, Takagi T, Tohyama M. Cloning and functional expression of a brain peptide/histidine transporter. J Biol Chem. 1997 Apr 11;272(15):10205-11. PubMed PMID: 9092568.