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MedKoo Cat#: 563152 | Name: Meclofenoxate HCl
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Meclofenoxate HCl is a potent nootropic agent.

Chemical Structure

Meclofenoxate HCl
Meclofenoxate HCl
CAS#3685-84-5

Theoretical Analysis

MedKoo Cat#: 563152

Name: Meclofenoxate HCl

CAS#: 3685-84-5

Chemical Formula: C12H17Cl2NO3

Exact Mass: 293.0585

Molecular Weight: 294.17

Elemental Analysis: C, 49.00; H, 5.83; Cl, 24.10; N, 4.76; O, 16.32

Price and Availability

Size Price Availability Quantity
10g USD 350.00 2 weeks
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Related CAS #
No Data
Synonym
Meclofenoxate Hydrochloride; Meclofenoxate HCl; Meclofenoxate; Centrophenoxine hydrochloride; Centrophenoxine; Cerutil, Lucidril; Helfergin; Marucotol; Acefen; Atsefen; Brenal;
IUPAC/Chemical Name
2-(Dimethylamino)ethyl 2-(4-chlorophenoxy)acetate hydrochloride
InChi Key
FIVHOHCAXWQPGC-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H16ClNO3.ClH/c1-14(2)7-8-16-12(15)9-17-11-5-3-10(13)4-6-11;/h3-6H,7-9H2,1-2H3;1H
SMILES Code
O=C(OCCN(C)C)COC1=CC=C(Cl)C=C1.[H]Cl
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Meclofenoxate hydrochloride, an ester of dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA), has been shown to improve memory, have a mentally stimulating effect, and improve general cognition.
In vitro activity:
After testing 1280 pharmaceutically active compounds, this study identified meclofenoxate HCl and its hydrolysis product, dimethylaminoethanol (DMAE), as suppressors of dioxygenase intoxication in SDH-loss yeast cells. Reference: Endocr Relat Cancer. 2022 May 11;29(6):345-358. https://pubmed.ncbi.nlm.nih.gov/35315791/
In vivo activity:
Meclofenoxate, administered in a dose of 50 mg/kg twice daily for 7 days using the maze-training method, increased the number of responses to the conditioned stimulus, when retention tests were made 24 hours and 7 days after training, whereas citicholine, applied in the same way in a dose of 10 mg/kg, shortened the latency of the responses with reinforcement during the training and increased the number of correct responses to the conditioned stimulus in retention tests 7 days after the training. Reference: Acta Physiol Pharmacol Bulg. 1987;13(4):17-24. PMID https://pubmed.ncbi.nlm.nih.gov/3129903/
Solvent mg/mL mM
Solubility
DMSO 47.0 159.77
Ethanol 30.5 103.68
PBS (pH 7.2) 10.0 34.00
Water 45.7 155.23
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 294.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Beimers W, Braun M, Schwinefus K, Pearson K, Wilbanks B, Maher LJ. A suppressor of dioxygenase inhibition in a yeast model of SDH deficiency. Endocr Relat Cancer. 2022 May 11;29(6):345-358. doi: 10.1530/ERC-21-0349. PMID: 35315791; PMCID: PMC9175558. 2. Bakhtogarimov IR, Kudryavtseva AV, Krasnov GS, Gladysh NS, Volodin VV, Kudryavtsev AA, Bulavkina EV, Goncharova MA, Ledyaeva VS, Pastukhov IS, Vershinina YS, Starkova AM, Snezhkina AV, Shuvalova AI, Pavlov VS, Nikiforov-Nikishin DL, Moskalev AA, Guvatova ZG. The Effect of Meclofenoxate on the Transcriptome of Aging Brain of Nothobranchius guentheri Annual Killifish. Int J Mol Sci. 2022 Feb 24;23(5):2491. doi: 10.3390/ijms23052491. PMID: 35269638; PMCID: PMC8910246. 3. Mosharrof AH, Petkov VD, Petkov VV. Effects of meclofenoxate and citicholine on learning and memory in aged rats. Acta Physiol Pharmacol Bulg. 1987;13(4):17-24. PMID: 3129903.
In vitro protocol:
1. Beimers W, Braun M, Schwinefus K, Pearson K, Wilbanks B, Maher LJ. A suppressor of dioxygenase inhibition in a yeast model of SDH deficiency. Endocr Relat Cancer. 2022 May 11;29(6):345-358. doi: 10.1530/ERC-21-0349. PMID: 35315791; PMCID: PMC9175558.
In vivo protocol:
1. Bakhtogarimov IR, Kudryavtseva AV, Krasnov GS, Gladysh NS, Volodin VV, Kudryavtsev AA, Bulavkina EV, Goncharova MA, Ledyaeva VS, Pastukhov IS, Vershinina YS, Starkova AM, Snezhkina AV, Shuvalova AI, Pavlov VS, Nikiforov-Nikishin DL, Moskalev AA, Guvatova ZG. The Effect of Meclofenoxate on the Transcriptome of Aging Brain of Nothobranchius guentheri Annual Killifish. Int J Mol Sci. 2022 Feb 24;23(5):2491. doi: 10.3390/ijms23052491. PMID: 35269638; PMCID: PMC8910246. 2. Mosharrof AH, Petkov VD, Petkov VV. Effects of meclofenoxate and citicholine on learning and memory in aged rats. Acta Physiol Pharmacol Bulg. 1987;13(4):17-24. PMID: 3129903.
1: Wada F, Ono T, Ikeda C. [Effect of drug-administration on physiological function of hemoglobin (author's transl)]. Nihon Yakurigaku Zasshi. 1981 May;77(5):447-58. Japanese. PubMed PMID: 7297957.