Emofolin sodium | CAS#52386-42-2 | sodium salt of antimetabolite folate analog

MedKoo Cat#: 597207 | Name: Emofolin sodium

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Emofolin sodium is the sodium salt of a synthetic antimetabolite analogue of folate with antineoplastic activity. Emfolin sodium competes for the folate binding site of the enzyme dihydrofolate reductase, resulting in inhibition of tetrahydrofolate synthesis, depletion of nucleotide pools, and inhibition of DNA, RNA and protein synthesis.

Chemical Structure

Emofolin sodium

CAS#52386-42-2 (sodium)

Theoretical Analysis

MedKoo Cat#: 597207

Name: Emofolin sodium

CAS#: 52386-42-2 (sodium)

Chemical Formula: C21H25N7Na2O6

Exact Mass: 0.0000

Molecular Weight: 517.45

Elemental Analysis: C, 48.74; H, 4.87; N, 18.95; Na, 8.89; O, 18.55

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

52196-22-2 (free base) 52386-42-2 (sodium)

Synonym

Emofolin sodium; NSC 139490; NSC-139490; NSC139490; MeTHHF disodium;

IUPAC/Chemical Name

sodium (4-((2-(2-amino-5-methyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)ethyl)amino)benzoyl)-L-glutamate

InChi Key

PASPSZYIMAFFFK-HNYZGNTBSA-L

InChi Code

InChI=1S/C21H27N7O6.2Na/c1-28-13(10-24-17-16(28)19(32)27-21(22)26-17)8-9-23-12-4-2-11(3-5-12)18(31)25-14(20(33)34)6-7-15(29)30;;/h2-5,13-14,23H,6-10H2,1H3,(H,25,31)(H,29,30)(H,33,34)(H4,22,24,26,27,32);;/q;2*+1/p-2/t13?,14-;;/m0../s1

SMILES Code

O=C([O-])CC[C@@H](C([O-])=O)NC(C1=CC=C(NCCC2N(C)C3=C(NC(N)=NC3=O)NC2)C=C1)=O.[Na+].[Na+]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 517.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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