Synonym
N-Phthaloylglutamic acid; alpha-N-Phthaloylglutamic acid; PhGA; N,N-Phthaloyl-L-glutamic acid;
IUPAC/Chemical Name
(2-carboxybenzoyl)-L-glutamic acid
InChi Key
QIWKCQDJZPRXNS-VIFPVBQESA-N
InChi Code
InChI=1S/C13H13NO7/c15-10(16)6-5-9(13(20)21)14-11(17)7-3-1-2-4-8(7)12(18)19/h1-4,9H,5-6H2,(H,14,17)(H,15,16)(H,18,19)(H,20,21)/t9-/m0/s1
SMILES Code
O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=CC=C1C(O)=O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
295.24
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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5: Koreshonkov ON, Perestenko PV, Dumpis MA, Piotrovskiĭ LB. [Effects of N-phthalamoyl-L-glutaminic acid, a selective agonist of NMDA receptor, on binding of 3H-L-glutamate with synaptic membranes of the hippocampus]. Biull Eksp Biol Med. 1992 Jun;113(6):563-5. Russian. PubMed PMID: 1446016.
6: Kocher-Becker U, Kocher W, Ockenfels H. [Embryotoxic interactions between a hydrolysis product of thalidomide and the surfactant Tween 20 in mice]. Z Naturforsch C. 1992 Jan-Feb;47(1-2):155-69. German. PubMed PMID: 1610476.
7: Kiskin NI, Tsyndrenko AYa, Dumpis MA, Piotrovsky LB, Krishtal OA. A novel selective NMDA agonist, N-phthalamoyl-L-glutamic acid (PhGA). Neuroreport. 1991 Jan;2(1):29-32. PubMed PMID: 1685102.
8: Kocher-Becker U, Kocher W, Ockenfels H. Teratogenic activity of a hydrolytic thalidomide metabolite in mice. Naturwissenschaften. 1982 Apr;69(4):191-2. PubMed PMID: 7088198.
9: Gagliardi V. [Teratogenic effects induced by N-phthaloylglutamic acid imide in the maxillofacial region]. Riv Ital Stomatol. 1971 Apr;26(4):241-70. Italian. PubMed PMID: 5003550.
