HW161023 is a potent and orally active AAK1 inhibitor. HW161023 showed good inhibitory potency against AAK1 enzyme and satisfactory oral pharmacokinetic profile with weaker HepG2 cell toxicity and hERG inhibition than LX9211.
MedKoo Cat#: 128098
Name: HW161023
CAS#: N/A
Chemical Formula: C20H24F2N4O
Exact Mass: 374.1918
Molecular Weight: 374.44
Elemental Analysis: C, 64.16; H, 6.46; F, 10.15; N, 14.96; O, 4.27
The following data is based on the product molecular weight 374.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
