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MedKoo Cat#: 563102 | Name: Rhodblock 6
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Rhodblock 6 is an inhibitor of the Rho pathway. It acts by specifically abrogating Rho kinase activity.

Chemical Structure

Rhodblock 6
Rhodblock 6
CAS#886625-06-5

Theoretical Analysis

MedKoo Cat#: 563102

Name: Rhodblock 6

CAS#: 886625-06-5

Chemical Formula: C12H13N3O

Exact Mass: 215.1059

Molecular Weight: 215.25

Elemental Analysis: C, 66.96; H, 6.09; N, 19.52; O, 7.43

Price and Availability

Size Price Availability Quantity
5mg USD 350.00
25mg USD 800.00
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Related CAS #
No Data
Synonym
Rhodblock 6; Rhodblock-6; Rhodblock6;
IUPAC/Chemical Name
N-1H-Indazol-5-yl-cyclobutanecarboxamide
InChi Key
GXJXOQKXBIPBKB-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H13N3O/c16-12(8-2-1-3-8)14-10-4-5-11-9(6-10)7-13-15-11/h4-8H,1-3H2,(H,13,15)(H,14,16)
SMILES Code
O=C(C1CCC1)NC2=CC3=C(NN=C3)C=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Rhodblock 6 is an inhibitor of the Rho Kinase pathway. Rhodblock 6 directly inhibited Rok and its human ortholog ROCK I in a kinase assay.
In vitro activity:
This study discovered the molecules Rhodblock and identified their target as Rho kinase. Several Rhodblocks inhibited the correct localization of phosphorylated myosin light chain during cytokinesis. Rhodblocks differentially perturb Rho pathway proteins in cells and can be used to dissect the mechanism of the Rho pathway during cytokinesis. Reference: Nat Chem Biol. 2010 Jun;6(6):457-63. doi: 10.1038/nchembio.363. https://pubmed.ncbi.nlm.nih.gov/20436488/
In vivo activity:
To be determined

Preparing Stock Solutions

The following data is based on the product molecular weight 215.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Castoreno AB, Smurnyy Y, Torres AD, Vokes MS, Jones TR, Carpenter AE, Eggert US. Small molecules discovered in a pathway screen target the Rho pathway in cytokinesis. Nat Chem Biol. 2010 Jun;6(6):457-63. doi: 10.1038/nchembio.363. Epub 2010 May 2. PMID: 20436488; PMCID: PMC2873065.
In vitro protocol:
To be determined
In vivo protocol:
1. Castoreno AB, Smurnyy Y, Torres AD, Vokes MS, Jones TR, Carpenter AE, Eggert US. Small molecules discovered in a pathway screen target the Rho pathway in cytokinesis. Nat Chem Biol. 2010 Jun;6(6):457-63. doi: 10.1038/nchembio.363. Epub 2010 May 2. PMID: 20436488; PMCID: PMC2873065.
1: Castoreno AB, Smurnyy Y, Torres AD, Vokes MS, Jones TR, Carpenter AE, Eggert US. Small molecules discovered in a pathway screen target the Rho pathway in cytokinesis. Nat Chem Biol. 2010 Jun;6(6):457-63. doi: 10.1038/nchembio.363. Epub 2010 May 2. PubMed PMID: 20436488; PubMed Central PMCID: PMC2873065.