MedKoo Cat#: 563091 | Name: TC-S 7005
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

TC-S 7005 is a potent and selective polo-like kinase 2 (PLK2) inhibitor.

Chemical Structure

TC-S 7005
TC-S 7005
CAS#1082739-92-1

Theoretical Analysis

MedKoo Cat#: 563091

Name: TC-S 7005

CAS#: 1082739-92-1

Chemical Formula: C21H17N3O3

Exact Mass: 359.1270

Molecular Weight: 359.38

Elemental Analysis: C, 70.18; H, 4.77; N, 11.69; O, 13.36

Price and Availability

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10mg USD 600.00 2 Weeks
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Synonym
TC-S 7005; TC S 7005; TCS 7005; TCS-7005; TCS7005;
IUPAC/Chemical Name
3-(1,3-Benzodioxol-5-yl)-N-[(1S)-1-phenylethyl]-isoxazolo[5,4-c]pyridin-5-amine
InChi Key
DAAGOCSHXCDWDY-ZDUSSCGKSA-N
InChi Code
InChI=1S/C21H17N3O3/c1-13(14-5-3-2-4-6-14)23-20-10-16-19(11-22-20)27-24-21(16)15-7-8-17-18(9-15)26-12-25-17/h2-11,13H,12H2,1H3,(H,22,23)/t13-/m0/s1
SMILES Code
C[C@H](NC1=CC2=C(ON=C2C3=CC=C(OCO4)C4=C3)C=N1)C5=CC=CC=C5
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 359.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Valenti F, Ganci F, Sacconi A, Lo Sardo F, D'Andrea M, Sanguineti G, Di Agostino S. Polo-like kinase 2 targeting as novel strategy to sensitize mutant p53-expressing tumor cells to anticancer treatments. J Mol Med (Berl). 2024 Dec;102(12):1485-1501. doi: 10.1007/s00109-024-02499-5. Epub 2024 Oct 31. PMID: 39480521.