MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 529305 | Name: Tempol
Featured New

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tempol is an antioxidant and radioprotective agent potentially used in the prevention of alopecia induced by whole brain radiotherapy.

Chemical Structure

Tempol
Tempol
CAS#2226-96-2

Theoretical Analysis

MedKoo Cat#: 529305

Name: Tempol

CAS#: 2226-96-2

Chemical Formula: C9H18NO2•

Exact Mass: 172.1338

Molecular Weight: 172.24

Elemental Analysis: C, 62.76; H, 10.53; N, 8.13; O, 18.58

Price and Availability

Size Price Availability Quantity
1g USD 90.00 Ready to ship
2g USD 150.00 Ready to ship
5g USD 250.00 2 weeks
10g USD 350.00 2 weeks
20g USD 550.00 2 weeks
50g USD 950.00 2 weeks
Show More
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
NSC-142784, OT-674, NSC142784, OT674, NSC 142784, OT 674, Tempol
IUPAC/Chemical Name
1-Piperidinyloxy, 4-hydroxy-2,2,6,6-tetramethyl-
InChi Key
UZFMOKQJFYMBGY-UHFFFAOYSA-N
InChi Code
InChI=1S/C9H18NO2/c1-8(2)5-7(11)6-9(3,4)10(8)12/h7,11H,5-6H2,1-4H3
SMILES Code
[O]N1C(C)(C)CC(O)CC1(C)C
Appearance
Orange crystalline powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Certificate of Analysis
View CoA: current batch, Lot#T7C12I04
Safety Data Sheet (SDS)
View Safety Data Sheet (SDS)
Instruction
View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 172.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Pang Z, Sheberstov K, Rodin BA, Lumsden J, Banerjee U, Abergel D, Mentink- Vigier F, Bodenhausen G, Tan KO. Hypershifted spin spectroscopy with dynamic nuclear polarization at 1.4 K. Sci Adv. 2024 Dec 13;10(50):eadr7160. doi: 10.1126/sciadv.adr7160. Epub 2024 Dec 11. PMID: 39661685; PMCID: PMC11633758. 2: Ramachandran N, Ayoub N, Agrawal DK. Integrating Radioprotective Agents into Post-Mastectomy Radiotherapy: Optimization of Reconstructive Outcomes in Breast Cancer. J Surg Res (Houst). 2024;7(4):454-465. doi: 10.26502/jsr.10020395. Epub 2024 Oct 21. PMID: 39605991; PMCID: PMC11600463. 3: Najjar RS, Grace WW, Siqueira APS, Setka AM, Lu W, Wang S, Feresin RG. Polyphenols have unique cellular effects that are distinct from antioxidant function in Toll-like receptor 4-mediated inflammation in RAW264.7 macrophage- like cells. Nutr Res. 2024 Dec;132:136-151. doi: 10.1016/j.nutres.2024.10.007. Epub 2024 Oct 28. PMID: 39580917. 4: El-Fatah SSA, Nafea OE, Yousef DM, Samy W, Hussien MHS, Arakeep HM. Tempol mitigates inflammation, oxidative stress, and histopathological alterations of cadmium-induced parotid gland injury in rats. Life Sci. 2024 Dec 15;359:123233. doi: 10.1016/j.lfs.2024.123233. Epub 2024 Nov 8. PMID: 39522715. 5: Mata-Santos HA, Sousa Oliveira CV, Feijo DF, Vanzan DF, Vilar-Pereira G, Ramos IP, Carneiro VC, Moreno-Loaiza O, Silverio JC, Lannes-Vieira J, Medei E, Bozza MT, Paiva CN. Heart function enhancement by an Nrf2-activating antioxidant in acute Y-strain Chagas disease, but not in chronic Colombian or Y-strain. PLoS Negl Trop Dis. 2024 Nov 7;18(11):e0012612. doi: 10.1371/journal.pntd.0012612. PMID: 39509468; PMCID: PMC11588235. 6: Ouyang J, Wang H, Gan Y, Huang J. Uric acid mediates kidney tubular inflammation through the LDHA/ROS/NLRP3 pathway. Clin Exp Hypertens. 2024 Dec 31;46(1):2424834. doi: 10.1080/10641963.2024.2424834. Epub 2024 Nov 3. PMID: 39488824. 7: Richard A, Bocquet A, Belin de Chantemèle E, Retailleau K, Toutain B, Mongue- Din H, Guihot AL, Fassot C, Fromes Y, Henrion D, Loufrani L. Reduced microvascular flow-mediated dilation in Syrian hamsters lacking d-sarcoglycan is caused by increased oxidative stress. Am J Physiol Heart Circ Physiol. 2024 Nov 1. doi: 10.1152/ajpheart.00569.2024. Epub ahead of print. PMID: 39485294. 8: Koyasu N, Hyodo F, Iwasaki R, Elhelaly AE, Mori T, Noda Y, Kato H, Krishna MC, Kishimoto S, Matsuo M. Quantitative spatial visualization of X-ray irradiation via redox reaction by dynamic nuclear polarization magnetic resonance imaging. Free Radic Biol Med. 2024 Nov 20;225:388-397. doi: 10.1016/j.freeradbiomed.2024.10.278. Epub 2024 Oct 11. PMID: 39396582. 9: Lobov GI. [Contractive function of mesenteric lymph nodes in obese rats]. Vopr Pitan. 2024;93(4):39-48. Russian. doi: 10.33029/0042-8833-2024-93-4-39-48. Epub 2024 Jul 15. PMID: 39396214. 10: Wang H, Ortiz PA, Romero CA. Luminal Flow in the Connecting Tubule induces Afferent Arteriole Vasodilation. bioRxiv [Preprint]. 2024 Sep 17:2024.09.12.612758. doi: 10.1101/2024.09.12.612758. PMID: 39345602; PMCID: PMC11429694. 11: Segantini M, Marcozzi G, Elrifai T, Shabratova E, Höflich K, Deaconeasa M, Niemann V, Pietig R, McPeak JE, Anders J, Naydenov B, Lips K. Compact Electron Paramagnetic Resonance on a Chip Spectrometer Using a Single Sided Permanent Magnet. ACS Sens. 2024 Oct 25;9(10):5099-5108. doi: 10.1021/acssensors.4c00788. Epub 2024 Sep 26. PMID: 39326012; PMCID: PMC11519922. 12: Yang L, Zhu X, Zhu J, Hu Z, Wang C, Luo H, Bai X. Gestational diabetes causes hyperactivity of the sympathetic nervous system and hypertension in adult mice offspring. Clin Exp Hypertens. 2024 Dec 31;46(1):2402260. doi: 10.1080/10641963.2024.2402260. Epub 2024 Sep 20. PMID: 39305040. 13: McGarr GW, Li-Maloney C, King KE, Janetos KT, Fujii N, Amano T, Kenny GP. Modulation of cutaneous vasodilation by reactive oxygen species during local and whole body heating in young and older adults. Am J Physiol Regul Integr Comp Physiol. 2024 Dec 1;327(6):R543-R552. doi: 10.1152/ajpregu.00127.2024. Epub 2024 Sep 6. PMID: 39241006. 14: Shiroudi A, Śmiechowski M, Czub J, Abdel-Rahman MA. A Computational Analysis of the Proton Affinity and the Hydration of TEMPO and Its Piperidine Analogs. Chemphyschem. 2024 Sep 2:e202400518. doi: 10.1002/cphc.202400518. Epub ahead of print. PMID: 39222322. 15: Schreckenberg R, Schulz R, Itani N, Ferdinandy P, Bencsik P, Szabados T, Rohrbach S, Niemann B, Schlüter KD. Inhibition of MMP2 activity mitigates N-omega-nitro-l-arginine-methyl ester (l-NAME)-induced right heart failure. Redox Biol. 2024 Oct;76:103308. doi: 10.1016/j.redox.2024.103308. Epub 2024 Aug 15. PMID: 39167912; PMCID: PMC11381879. 16: Li XL, Qing SJ, Sun X, Yu Z, Xu HJ, Fu Y. Copper-Catalyzed Oxidation of 5-Hydroxymethylfurfural to 2,5-Diformylfuran Assisted by TEMPOL in Liquid Sunlight Methanol. ChemSusChem. 2024 Aug 21:e202401527. doi: 10.1002/cssc.202401527. Epub ahead of print. PMID: 39166715. 17: Vaneeckhaute E, Bocquelet C, Bellier L, Le HN, Rougier N, Jegadeesan SA, Vinod-Kumar S, Mathies G, Veyre L, Thieuleux C, Melzi R, Banks D, Kempf J, Stern Q, Jannin S. Full optimization of dynamic nuclear polarization on a 1 tesla benchtop polarizer with hyperpolarizing solids. Phys Chem Chem Phys. 2024 Aug 22;26(33):22049-22061. doi: 10.1039/d4cp02022g. PMID: 39114945; PMCID: PMC11307143. 18: Zeman RJ, Brown AM, Wen X, Ouyang N, Etlinger JD. Tempol, a Superoxide Dismutase Mimetic, Inhibits Wallerian Degeneration Following Spinal Cord Injury by Preventing Glutathione Depletion and Aldose Reductase Activation. J Neurotrauma. 2024 Sep;41(17-18):2186-2198. doi: 10.1089/neu.2024.0137. Epub 2024 Aug 21. PMID: 39083435. 19: Kozina N, Jukić I, Mihaljević Z, Matić A, Dobrivojević Radmilović M, Barić A, Drenjančević I. The Effect of High-Salt Diet on Oxidative Stress Production and Vascular Function in Tff3-/-/C57BL/6N Knockout and Wild Type (C57BL/6N) Mice. J Vasc Res. 2024;61(5):214-224. doi: 10.1159/000539614. Epub 2024 Jul 29. PMID: 39074455. 20: Hao WY, Wang JX, Xu XY, Chen JL, Chen Q, Li YH, Zhu GQ, Chen AD. Chemerin in caudal division of nucleus tractus solitarius increases sympathetic activity and blood pressure. Eur J Neurosci. 2024 Sep;60(5):4830-4842. doi: 10.1111/ejn.16475. Epub 2024 Jul 23. PMID: 39044301.

View History

Tempoacmcta

Tempoacmcta