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MedKoo Cat#: 563079 | Name: CD40-TRAF6 inhibitor
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

CD40-TRAF6 inhibitor is a CD40-TRAF6 interaction inhibitor.

Chemical Structure

CD40-TRAF6 inhibitor
CAS#433249-94-6

Theoretical Analysis

MedKoo Cat#: 563079

Name: CD40-TRAF6 inhibitor

CAS#: 433249-94-6

Chemical Formula: C17H17NO

Exact Mass: 251.1310

Molecular Weight: 251.32

Elemental Analysis: C, 81.24; H, 6.82; N, 5.57; O, 6.37

Price and Availability

Size Price Availability Quantity
5mg USD 350.00 2 Weeks
25mg USD 850.00 2 Weeks
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Related CAS #
No Data
Synonym
CD40-TRAF6 inhibitor; CD40 TRAF6 inhibitor; TRAF-STOP 6877002; SMI-6877002; CD40-TRAF6 inhibitor 6877002; SMI 6877002; SMI6877002
IUPAC/Chemical Name
(E)-3-((2,5-dimethylphenyl)amino)-1-phenylprop-2-en-1-one
InChi Key
SARYOFMRLSHZFE-ZHACJKMWSA-N
InChi Code
InChI=1S/C17H17NO/c1-13-8-9-14(2)16(12-13)18-11-10-17(19)15-6-4-3-5-7-15/h3-12,18H,1-2H3/b11-10+
SMILES Code
O=C(/C=C/NC1=C(C)C=CC(C)=C1)C2=CC=CC=C2
Appearance
Yellow solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Certificate of Analysis
View CoA: current batch, Lot#RND90319
Safety Data Sheet (SDS)
View Safety Data Sheet (SDS)
Instruction
View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 251.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Steven S, Dib M, Hausding M, Kashani F, Oelze M, Kröller-Schön S, Hanf A, Daub S, Roohani S, Gramlich Y, Lutgens E, Schulz E, Becker C, Lackner KJ, Kleinert H, Knosalla C, Niesler B, Wild PS, Münzel T, Daiber A. CD40L controls obesity-associated vascular inflammation, oxidative stress, and endothelial dysfunction in high fat diet-treated and db/db mice. Cardiovasc Res. 2018 Feb 1;114(2):312-323. doi: 10.1093/cvr/cvx197. PubMed PMID: 29036612. 2: Aarts SABM, Seijkens TTP, Kusters PJH, van der Pol SMA, Zarzycka B, Heijnen PDAM, Beckers L, den Toom M, Gijbels MJJ, Boon L, Weber C, de Vries HE, Nicolaes GAF, Dijkstra CD, Kooij G, Lutgens E. Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation. J Neuroinflammation. 2017 May 12;14(1):105. doi: 10.1186/s12974-017-0875-9. PubMed PMID: 28494768; PubMed Central PMCID: PMC5427621. 3: van den Berg SM, Seijkens TT, Kusters PJ, Zarzycka B, Beckers L, den Toom M, Gijbels MJ, Chatzigeorgiou A, Weber C, de Winther MP, Chavakis T, Nicolaes GA, Lutgens E. Blocking CD40-TRAF6 interactions by small-molecule inhibitor 6860766 ameliorates the complications of diet-induced obesity in mice. Int J Obes (Lond). 2015 May;39(5):782-90. doi: 10.1038/ijo.2014.198. Epub 2014 Nov 13. PubMed PMID: 25394307. 4: Chatzigeorgiou A, Seijkens T, Zarzycka B, Engel D, Poggi M, van den Berg S, van den Berg S, Soehnlein O, Winkels H, Beckers L, Lievens D, Driessen A, Kusters P, Biessen E, Garcia-Martin R, Klotzsche-von Ameln A, Gijbels M, Noelle R, Boon L, Hackeng T, Schulte KM, Xu A, Vriend G, Nabuurs S, Chung KJ, Willems van Dijk K, Rensen PC, Gerdes N, de Winther M, Block NL, Schally AV, Weber C, Bornstein SR, Nicolaes G, Chavakis T, Lutgens E. Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance. Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2686-91. doi: 10.1073/pnas.1400419111. Epub 2014 Feb 3. Erratum in: Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):4644. Schulte, Klaus [corrected to Schulte, Klaus-Martin]. PubMed PMID: 24492375; PubMed Central PMCID: PMC3932883.