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MedKoo Cat#: 563036 | Name: PQ-10
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

PQ-10 is a potent PDE-10 inhibitor. PQ-10 has >38-fold selectivity for PDE10 over a panel of 60 CNS-associated receptors, enzymes, and ion channels in vitro. PQ-10 is capable of suppressing tumor cell growth. PQ-10 can also reverse the RO-4-1284-induced sedation and catalepsy. PQ-10 enhances basic auditory information processing in rats. PQ-10 as other PED10 inhibitors suppresses a growth of human non-small cell lung cancer (NSCLC) cell lines.

Chemical Structure

PQ-10
PQ-10
CAS#927691-21-2

Theoretical Analysis

MedKoo Cat#: 563036

Name: PQ-10

CAS#: 927691-21-2

Chemical Formula: C22H21N5O3

Exact Mass: 403.1644

Molecular Weight: 403.44

Elemental Analysis: C, 65.50; H, 5.25; N, 17.36; O, 11.90

Price and Availability

Size Price Availability Quantity
50mg USD 550.00 2 Weeks
100mg USD 950.00 2 Weeks
200mg USD 1,550.00 2 Weeks
500mg USD 2,950.00 2 Weeks
1g USD 4,250.00 2 Weeks
2g USD 5,950.00 2 Weeks
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Related CAS #
No Data
Synonym
PQ-10; PQ 10; PQ10; A844337; A-844337; A 844337;
IUPAC/Chemical Name
6,7-Dimethoxy-4-[3-(quinoxalin-2-yloxy)pyrrolidin-1-yl]quinazoline
InChi Key
UBIIFKJMNRPNMT-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H21N5O3/c1-28-19-9-15-18(10-20(19)29-2)24-13-25-22(15)27-8-7-14(12-27)30-21-11-23-16-5-3-4-6-17(16)26-21/h3-6,9-11,13-14H,7-8,12H2,1-2H3
SMILES Code
COC1=CC2=NC=NC(N3CC(OC4=NC5=CC=CC=C5N=C4)CC3)=C2C=C1OC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
PQ-10 is an inhibitor of PDE-10.
In vitro activity:
TBD
In vivo activity:
The effects of the PDE2 inhibitor BAY 60-7550 and the PDE10 inhibitor PQ-10 on object recognition performance were investigated in the scopolamine (0.1mg/kg, i.p.) or MK-801 (0.125 mg/kg, i.p.) model. BAY 60-7550 was tested at a dose of 0.3-3mg/kg (p.o.) in both models; PQ-10 was tested at doses of 0.1-1mg/kg (p.o.) in the scopolamine model and 0.3-3mg/kg in the MK-801 model. All compounds were injected 30 min before the learning trial. Both BAY 60-7550 (1mg/kg) and PQ-10 (0.3mg/kg) attenuated the scopolamine-induced memory deficit. The MK-801-induced memory deficit was reversed after treatment with each PDE inhibitor at a dose of 1mg/kg or higher. PQ10 was highly brain penetrant, whereas 60-7550 levels in the brain were very low after oral treatment. Reference: Behav Brain Res. 2013 Jan 1;236(1):16-22. https://pubmed.ncbi.nlm.nih.gov/22951181/
Solvent mg/mL mM comments
Solubility
DMF 25.0 61.97
DMF:PBS (pH 7.2) (1:20) 0.0 0.10
DMSO 16.0 39.66
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 403.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
Reneerkens OAH, Rutten K, Bollen E, Hage T, Blokland A, Steinbusch HWM, Prickaerts J. Inhibition of phoshodiesterase type 2 or type 10 reverses object memory deficits induced by scopolamine or MK-801. Behav Brain Res. 2013 Jan 1;236(1):16-22. doi: 10.1016/j.bbr.2012.08.019. Epub 2012 Aug 19. PMID: 22951181.
In vitro protocol:
TBD
In vivo protocol:
Reneerkens OAH, Rutten K, Bollen E, Hage T, Blokland A, Steinbusch HWM, Prickaerts J. Inhibition of phoshodiesterase type 2 or type 10 reverses object memory deficits induced by scopolamine or MK-801. Behav Brain Res. 2013 Jan 1;236(1):16-22. doi: 10.1016/j.bbr.2012.08.019. Epub 2012 Aug 19. PMID: 22951181.
1: Imam RA, Hassan FE, Ali IH, Alghamdi MA, Aboulhoda BE. Effect of Selenium nanoparticles on Paraquat-induced-neuroinflammation and oligodendocyte modulation: Implication of the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathway. Tissue Cell. 2024 Aug;89:102454. doi: 10.1016/j.tice.2024.102454. Epub 2024 Jun 19. PMID: 38905876. 2: Enemali FU, Iteire KA, Uweigho RE, Blessing O, Judah GT. Aqueous leaf extract of Phyllanthus amarus protects against oxidative stress and misfiring of dopaminergic neurons in Paraquat-induced Parkinson's disease-like model of adult Wistar rats. J Chem Neuroanat. 2024 Jan;135:102365. doi: 10.1016/j.jchemneu.2023.102365. Epub 2023 Nov 27. PMID: 38030098. 3: Santos-García D, de Deus Fonticoba T, Cores Bartolomé C, Feal Painceiras MJ, García Díaz I, Alvarado MCÍ, Paz JM, Jesús S, Cosgaya M, Caldentey JG, Caballol N, Legarda I, Hernández Vara J, Cabo I, López Manzanares L, González Aramburu I, Ávila Rivera MA, Gómez Mayordomo V, Nogueira V, Dotor García-Soto J, Borrué C, Solano Vila B, Álvarez Sauco M, Vela L, Escalante S, Cubo E, Mendoza Z, Martínez Castrillo JC, Sánchez Alonso P, Alonso Losada MG, López Ariztegui N, Gastón I, Kulisevsky J, Seijo M, Valero C, Alonso Redondo R, Buongiorno MT, Ordás C, Menéndez-González M, McAfee D, Martinez-Martin P, Mir P; COPPADIS Study Group. Staging Parkinson's disease according to the MNCD classification correlates with caregiver burden. Brain Behav. 2023 Dec;13(12):e3295. doi: 10.1002/brb3.3295. Epub 2023 Nov 8. PMID: 37939322; PMCID: PMC10726881. 4: Han Y, Wei H, Du Y, Li Z, Feng SP, Huang B, Xu D. Ultrasensitive Flexible Thermal Sensor Arrays based on High-Thermopower Ionic Thermoelectric Hydrogel. Adv Sci (Weinh). 2023 Sep;10(25):e2302685. doi: 10.1002/advs.202302685. Epub 2023 Jul 3. PMID: 37395372; PMCID: PMC10477880. 5: Santos-García D, de Deus Fonticoba T, Cores Bartolomé C, Feal Painceiras MJ, Íñiguez-Alvarado MC, García Díaz I, Jesús S, Buongiorno MT, Planellas L, Cosgaya M, García Caldentey J, Caballol N, Legarda I, Hernández Vara J, Cabo I, López Manzanares L, González Aramburu I, Ávila Rivera MA, Gómez Mayordomo V, Nogueira V, Puente V, Dotor García-Soto J, Borrué C, Solano Vila B, Álvarez Sauco M, Vela L, Escalante S, Cubo E, Carrillo Padilla F, Martínez Castrillo JC, Sánchez Alonso P, Alonso Losada MG, López Ariztegui N, Gastón I, Kulisevsky J, Menéndez González M, Seijo M, Ruiz Martínez J, Valero C, Kurtis M, González Ardura J, Alonso Redondo R, Ordás C, López Díaz LM, McAfee D, Calopa M, Carrillo F, Escamilla Sevilla F, Freire-Alvarez E, Gómez Esteban JC, García Ramos R, Luquín MRI, Martínez-Torres I, Sesar Ignacio Á, Martinez-Martin P, Mir P; COPPADIS Study Group. Staging Parkinson's Disease According to the MNCD (Motor/Non- motor/Cognition/Dependency) Classification Correlates with Disease Severity and Quality of Life. J Parkinsons Dis. 2023;13(3):379-402. doi: 10.3233/JPD-225073. PMID: 36911948; PMCID: PMC10200155. 6: Jastrzębska-Więsek M, Kotańska M, Grzeszczak A, Jaromin A, Walczak M, Partyka A, Gdula-Argasińska J, Smolik M, Zagórska A. The Antidepressant-like Activity, Effects on Recognition Memory Deficits, Bioavailability, and Safety after Chronic Administration of New Dual-Acting Small Compounds Targeting Neuropsychiatric Symptoms in Dementia. Int J Mol Sci. 2022 Sep 28;23(19):11452. doi: 10.3390/ijms231911452. PMID: 36232749; PMCID: PMC9569954. 7: Ponizovsky A, Schaefer E, Stanton K, Heisler R. Adsorption isotherms of Polyquaternium-10 polymers by activated sludge solids. Chemosphere. 2022 Nov;307(Pt 2):135891. doi: 10.1016/j.chemosphere.2022.135891. Epub 2022 Aug 1. PMID: 35926742. 8: Rawlings JM, Belanger SE, Connors KA, Karb MJ, Thomas JB, Roush KS, Sanderson H. Understanding Ecotoxicological Responses of Fish Embryos and Gill Cells to Cationic Polymers. Environ Toxicol Chem. 2022 Sep;41(9):2259-2272. doi: 10.1002/etc.5410. Epub 2022 Jul 25. PMID: 35703088. 9: Santos García D, De Deus Fonticoba T, Paz González JM, Cores Bartolomé C, Valdés Aymerich L, Muñoz Enríquez JG, Suárez E, Jesús S, Aguilar M, Pastor P, Planellas LL, Cosgaya M, García Caldentey J, Caballol N, Legarda I, Hernández Vara J, Cabo I, López Manzanares L, González Aramburu I, Ávila Rivera MA, Catalán MJ, Nogueira V, Puente V, García Moreno JM, Borrué C, Solano Vila B, Álvarez Sauco M, Vela L, Escalante S, Cubo E, Carrillo Padilla F, Martínez Castrillo JC, Sánchez Alonso P, Alonso Losada MG, López Ariztegui N, Gastón I, Kulisevsky J, Blázquez Estrada M, Seijo M, Rúiz Martínez J, Valero C, Kurtis M, de Fábregues O, González Ardura J, Ordás C, López Díaz L, Mir P, Martinez-Martin P, Coppadis Study Group. Staging Parkinson's Disease Combining Motor and Nonmotor Symptoms Correlates with Disability and Quality of Life. Parkinsons Dis. 2021 May 13;2021:8871549. doi: 10.1155/2021/8871549. PMID: 34094501; PMCID: PMC8140853. 10: Naspolini NF, Heinz Rieg CE, Cenci VH, Cattani D, Zamoner A. Paraquat induces redox imbalance and disrupts glutamate and energy metabolism in the hippocampus of prepubertal rats. Neurotoxicology. 2021 Jul;85:121-132. doi: 10.1016/j.neuro.2021.05.010. Epub 2021 May 25. PMID: 34048864. 11: Fathy SM, El-Dash HA, Said NI. Neuroprotective effects of pomegranate (Punica granatum L.) juice and seed extract in paraquat-induced mouse model of Parkinson's disease. BMC Complement Med Ther. 2021 Apr 26;21(1):130. doi: 10.1186/s12906-021-03298-y. PMID: 33902532; PMCID: PMC8074500. 12: Lin CC, Hsu KH, Shih CP, Chang GJ. Hemodynamic and electromechanical effects of paraquat in rat heart. PLoS One. 2021 Apr 1;16(4):e0234591. doi: 10.1371/journal.pone.0234591. PMID: 33793552; PMCID: PMC8016255. 13: Tajai P, Suriyo T, Rangkadilok N, Fedeles B, Essigmann JM, Satayavivad J. Andrographolide, an Antioxidant, Counteracts Paraquat- Induced Mutagenesis in Mammalian Cells. Asian Pac J Cancer Prev. 2021 Feb 1;22(S1):3-8. doi: 10.31557/APJCP.2021.22.S1.3. PMID: 33576206. 14: Pan H, Bu YN, Lian WJ, Zhang SL, Sun SH, Han J. Solution and rheological properties of cationic cellulose/gemini surfactant: Effect of the alkyl chain and spacer length. Carbohydr Polym. 2020 Jun 15;238:116200. doi: 10.1016/j.carbpol.2020.116200. Epub 2020 Mar 25. PMID: 32299568. 15: Santos-García D, de Deus Fonticoba T, Suárez Castro E, Aneiros Díaz A, McAfee D. 5-2-1 Criteria: A Simple Screening Tool for Identifying Advanced PD Patients Who Need an Optimization of Parkinson's Treatment. Parkinsons Dis. 2020 Mar 24;2020:7537924. doi: 10.1155/2020/7537924. PMID: 32269748; PMCID: PMC7128051. 16: Rees GJ , Day SP , Barnsley KE , Iuga D , Yates JR , Wallis JD , Hanna JV . Measuring multiple 17O-13C J-couplings in naphthalaldehydic acid: a combined solid state NMR and density functional theory approach. Phys Chem Chem Phys. 2020 Feb 12;22(6):3400-3413. doi: 10.1039/c9cp03977e. PMID: 31984388. 17: Santos García D, de Deus Fonticoba T, Suárez Castro E, Borrué C, Mata M, Solano Vila B, Cots Foraster A, Álvarez Sauco M, Rodríguez Pérez AB, Vela L, Macías Y, Escalante S, Esteve P, Reverté Villarroya S, Cubo E, Casas E, Arnaiz S, Carrillo Padilla F, Pueyo Morlans M, Mir P, Martinez-Martin P; Coppadis Study Group. Non-motor symptoms burden, mood, and gait problems are the most significant factors contributing to a poor quality of life in non-demented Parkinson's disease patients: Results from the COPPADIS Study Cohort. Parkinsonism Relat Disord. 2019 Sep;66:151-157. doi: 10.1016/j.parkreldis.2019.07.031. Epub 2019 Jul 29. PMID: 31409572. 18: Krishna G, Hosamani R, Muralidhara. Bacopa monnieri Supplements Offset Paraquat-Induced Behavioral Phenotype and Brain Oxidative Pathways in Mice. Cent Nerv Syst Agents Med Chem. 2019;19(1):57-66. doi: 10.2174/1871524919666190115125900. PMID: 30644349. 19: Schapochnik A, da Silva MR, Leal MP, Esteves J, Hebeda CB, Sandri S, de Fátima Teixeira da Silva D, Farsky SHP, Marcos RL, Lino-Dos-Santos-Franco A. Vitamin D treatment abrogates the inflammatory response in paraquat-induced lung fibrosis. Toxicol Appl Pharmacol. 2018 Sep 15;355:60-67. doi: 10.1016/j.taap.2018.06.020. Epub 2018 Jun 23. PMID: 29944852. 20: Ferguson SA, Wang X, Mahoney M, Meyerhoff ME. Detection and Quantification of Polyquaterniums via Polyion-Sensitive Ion-Selective Optodes Inkjet Printed on Cellulose Paper. Anal Sci. 2018;34(1):45-50. doi: 10.2116/analsci.34.45. PMID: 29321456. 11: Coughlan C, Walker DI, Lohr KM, Richardson JR, Saba LM, Caudle WM, Fritz KS, Roede JR. Comparative Proteomic Analysis of Carbonylated Proteins from the Striatum and Cortex of Pesticide-Treated Mice. Parkinsons Dis. 2015;2015:812532. doi: 10.1155/2015/812532. Epub 2015 Aug 9. PubMed PMID: 26345149; PubMed Central PMCID: PMC4546751. 12: Shao X, Li M, Luo C, Wang YY, Lu YY, Feng S, Li H, Lang XB, Wang YC, Lin C, Shen XJ, Zhou Q, Jiang H, Chen JH. Effects of rapamycin against paraquat-induced pulmonary fibrosis in mice. J Zhejiang Univ Sci B. 2015 Jan;16(1):52-61. doi: 10.1631/jzus.B1400229. PubMed PMID: 25559956; PubMed Central PMCID: PMC4288945. 13: Schwan G, Barbar Asskar G, Höfgen N, Kubicova L, Funke U, Egerland U, Zahn M, Nieber K, Scheunemann M, Sträter N, Brust P, Briel D. Fluorine-containing 6,7-dialkoxybiaryl-based inhibitors for phosphodiesterase 10 A: synthesis and in vitro evaluation of inhibitory potency, selectivity, and metabolism. ChemMedChem. 2014 Jul;9(7):1476-87. doi: 10.1002/cmdc.201300522. Epub 2014 Apr 11. PubMed PMID: 24729456. 14: Santos-García D, de la Fuente-Fernández R. Impact of non-motor symptoms on health-related and perceived quality of life in Parkinson's disease. J Neurol Sci. 2013 Sep 15;332(1-2):136-40. doi: 10.1016/j.jns.2013.07.005. Epub 2013 Jul 25. PubMed PMID: 23890935. 15: Reneerkens OA, Sambeth A, Blokland A, Prickaerts J. PDE2 and PDE10, but not PDE5, inhibition affect basic auditory information processing in rats. Behav Brain Res. 2013 Aug 1;250:251-6. doi: 10.1016/j.bbr.2013.05.014. Epub 2013 May 17. PubMed PMID: 23688598. 16: Hosamani R; Muralidhara. Acute exposure of Drosophila melanogaster to paraquat causes oxidative stress and mitochondrial dysfunction. Arch Insect Biochem Physiol. 2013 May;83(1):25-40. doi: 10.1002/arch.21094. Epub 2013 Apr 5. PubMed PMID: 23564607. 17: Fahim MA, Shehab S, Nemmar A, Adem A, Dhanasekaran S, Hasan MY. Daily subacute paraquat exposure decreases muscle function and substantia nigra dopamine level. Physiol Res. 2013;62(3):313-21. Epub 2013 Mar 14. PubMed PMID: 23489189. 18: Reneerkens OA, Rutten K, Bollen E, Hage T, Blokland A, Steinbusch HW, Prickaerts J. Inhibition of phoshodiesterase type 2 or type 10 reverses object memory deficits induced by scopolamine or MK-801. Behav Brain Res. 2013 Jan 1;236(1):16-22. doi: 10.1016/j.bbr.2012.08.019. Epub 2012 Aug 19. PubMed PMID: 22951181. 19: Brignole-Baudouin F, Riancho L, Liang H, Baudouin C. Comparative in vitro toxicology study of travoprost polyquad-preserved, travoprost BAK-preserved, and latanoprost BAK-preserved ophthalmic solutions on human conjunctival epithelial cells. Curr Eye Res. 2011 Nov;36(11):979-88. doi: 10.3109/02713683.2011.578781. PubMed PMID: 21999224. 20: Gebhard C, Stähli BE, Shi Y, Camici GG, Akhmedov A, Hoegger L, Lohmann C, Matter CM, Hassa PO, Hottiger MO, Malinski T, Lüscher TF, Tanner FC. Poly(ADP-ribose) polymerase-1 protects from oxidative stress induced endothelial dysfunction. Biochem Biophys Res Commun. 2011 Nov 4;414(4):641-6. doi: 10.1016/j.bbrc.2011.09.029. Epub 2011 Oct 1. PubMed PMID: 21982765.