Synonym
MreB Perturbing Compound A22; A22 hydrochloride.
IUPAC/Chemical Name
S-(3,4-Dichlorobenzyl)isothiourea hydrochloride
InChi Key
VBJNMXMOMSWRDV-UHFFFAOYSA-N
InChi Code
InChI=1S/C8H8Cl2N2S.ClH/c9-6-2-1-5(3-7(6)10)4-13-8(11)12;/h1-3H,4H2,(H3,11,12);1H
SMILES Code
N=C(N)SCC1=CC=C(Cl)C(Cl)=C1.[H]Cl
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
271.58
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Bonez PC, Rossi GG, Bandeira JR, Ramos AP, Mizdal CR, Agertt VA, Dalla Nora
ESS, de Souza ME, Dos Santos Alves CF, Dos Santos FS, Gündel A, de Almeida
Vaucher R, Santos RCV, de Campos MMA. Anti-biofilm activity of A22
((S-3,4-dichlorobenzyl) isothiourea hydrochloride) against Pseudomonas
aeruginosa: Influence on biofilm formation, motility and bioadhesion. Microb
Pathog. 2017 Oct;111:6-13. doi: 10.1016/j.micpath.2017.08.008. Epub 2017 Aug 10.
PubMed PMID: 28804018.
2: Bonez PC, Ramos AP, Nascimento K, Copetti PM, Souza ME, Rossi GG, Agertt VA,
Sagrillo MR, Santos RC, Campos MM. Antibacterial, cyto and genotoxic activities
of A22 compound ((S-3, 4 -dichlorobenzyl) isothiourea hydrochloride). Microb
Pathog. 2016 Oct;99:14-18. doi: 10.1016/j.micpath.2016.07.007. Epub 2016 Jul 16.
PubMed PMID: 27427089.
3: Nicholson A, Perry JD, James AL, Stanforth SP, Carnell S, Wilkinson K, Anjam
Khan CM, De Soyza A, Gould FK. In vitro activity of
S-(3,4-dichlorobenzyl)isothiourea hydrochloride and novel structurally related
compounds against multidrug-resistant bacteria, including Pseudomonas aeruginosa
and Burkholderia cepacia complex. Int J Antimicrob Agents. 2012 Jan;39(1):27-32.
doi: 10.1016/j.ijantimicag.2011.08.015. Epub 2011 Oct 10. PubMed PMID: 21993484.
