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MedKoo Cat#: 563071 | Name: SKLB70326

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SKLB70326 is an inhibitor of cell-cycle progression. It acts by inducing G0/G1 phase arrest and apoptosis in human hepatic carcinoma cells.

Chemical Structure

SKLB70326
SKLB70326
CAS#1257317-77-3

Theoretical Analysis

MedKoo Cat#: 563071

Name: SKLB70326

CAS#: 1257317-77-3

Chemical Formula: C15H13N3O2S

Exact Mass: 299.0728

Molecular Weight: 299.34

Elemental Analysis: C, 60.19; H, 4.38; N, 14.04; O, 10.69; S, 10.71

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SKLB70326; SKLB-70326; SKLB 70326;
IUPAC/Chemical Name
3-Amino-6-(3-methoxyphenyl)thieno[2.3-b]pyridine-2-carboxamide
InChi Key
FEHLZYWXCFELFL-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H13N3O2S/c1-20-9-4-2-3-8(7-9)11-6-5-10-12(16)13(14(17)19)21-15(10)18-11/h2-7H,16H2,1H3,(H2,17,19)
SMILES Code
O=C(C1=C(N)C2=CC=C(C3=CC=CC(OC)=C3)N=C2S1)N
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 299.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Han Y, He H, Peng F, Liu J, Dai X, Lin H, Xu Y, Zhou T, Mao Y, Xie G, Yang S, Yu L, Yang L, Zhao Y. SKLB70326, a novel small-molecule inhibitor of cell-cycle progression, induces G₀/G₁ phase arrest and apoptosis in human hepatic carcinoma cells. Biochem Biophys Res Commun. 2012 May 18;421(4):684-9. doi: 10.1016/j.bbrc.2012.04.062. Epub 2012 Apr 21. PubMed PMID: 22542944.