SL44 is a Human Caseinolytic Protease P Agonists for the Treatment of Hepatocellular Carcinoma. SL44 exhibited potent HsClpP agonistic activity in the α-casein hydrolysis assay (EC50 = 1.30 μM) and inhibited the proliferation of HCCLM3 cells (IC50 = 3.1 μM, 21.4-fold higher than hit ADX-47273). Mechanistically, SL44 induces degradation of respiratory chain complex subunits and leads to apoptosis in HCC cells. In vivo results demonstrated that SL44 has potent tumor growth inhibitory activity and has a superior safety profile compared to the kinase inhibitor sorafenib.
MedKoo Cat#: 127315
Name: SL44
CAS#: N/A
Chemical Formula: C22H20ClFN4O
Exact Mass: 410.1310
Molecular Weight: 410.88
Elemental Analysis: C, 64.31; H, 4.91; Cl, 8.63; F, 4.62; N, 13.64; O, 3.89
The following data is based on the product molecular weight 410.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
