MedKoo Cat#: 563070 | Name: rac-NBI-74330
Featured New

Description:

WARNING: This product is for research use only, not for human or veterinary use.

rac-NBI-74330 is a potent and selective CXCR3 antagonist.

Chemical Structure

rac-NBI-74330
rac-NBI-74330
CAS#473722-68-8 (racemate)

Theoretical Analysis

MedKoo Cat#: 563070

Name: rac-NBI-74330

CAS#: 473722-68-8 (racemate)

Chemical Formula: C32H27F4N5O3

Exact Mass: 605.2050

Molecular Weight: 605.59

Elemental Analysis: C, 63.47; H, 4.49; F, 12.55; N, 11.56; O, 7.93

Price and Availability

Size Price Availability Quantity
10mg USD 350.00 2 Weeks
25mg USD 550.00 2 Weeks
50mg USD 950.00 2 Weeks
100mg USD 1,650.00 2 Weeks
1g USD 5,450.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Synonym
rac-NBI-74330; rac NBI 74330; racNBI74330; (±)-NBI-74330
IUPAC/Chemical Name
N-(1-(3-(4-ethoxyphenyl)-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)ethyl)-2-(4-fluoro-3-(trifluoromethyl)phenyl)-N-(pyridin-3-ylmethyl)acetamide
InChi Key
XMRGQUDUVGRCBS-UHFFFAOYSA-N
InChi Code
InChI=1S/C32H27F4N5O3/c1-3-44-24-11-9-23(10-12-24)41-30(39-29-25(31(41)43)7-5-15-38-29)20(2)40(19-22-6-4-14-37-18-22)28(42)17-21-8-13-27(33)26(16-21)32(34,35)36/h4-16,18,20H,3,17,19H2,1-2H3
SMILES Code
FC(F)(F)C1=CC(CC(N(C(C2=NC(N=CC=C3)=C3C(N2C4=CC=C(OCC)C=C4)=O)C)CC5=CC=CN=C5)=O)=CC=C1F
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 605.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Piotrowska A, Rojewska E, Pawlik K, Kreiner G, Ciechanowska A, Makuch W, Zychowska M, Mika J. Pharmacological blockade of CXCR3 by (±)-NBI-74330 reduces neuropathic pain and enhances opioid effectiveness - Evidence from in vivo and in vitro studies. Biochim Biophys Acta Mol Basis Dis. 2018 Oct;1864(10):3418-3437. doi: 10.1016/j.bbadis.2018.07.032. Epub 2018 Aug 1. PMID: 30076959.