HPi1 | CAS#13080-21-2 | antimicrobial agent

MedKoo Cat#: 563065 | Name: HPi1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

HPi1 is a selective antimicrobial against helicobacter pylori. It acts as an inhibitor of the acetyltransferase activity of Escherichia coli N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU).

Chemical Structure

HPi1

CAS#13080-21-2

Theoretical Analysis

MedKoo Cat#: 563065

Name: HPi1

CAS#: 13080-21-2

Chemical Formula: C8H8N4S

Exact Mass: 192.0470

Molecular Weight: 192.24

Elemental Analysis: C, 49.98; H, 4.19; N, 29.14; S, 16.68

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

HPi1; HPi-1; HPi 1; GlmU-IN-5215319; GlmU IN 5215319; GlmUIN5215319; GlmU inhibitor 5215319;

IUPAC/Chemical Name

3-Hydrazinoquinoxaline-2-thiol

InChi Key

TVYAHCDRRICQJM-UHFFFAOYSA-N

InChi Code

InChI=1S/C8H8N4S/c9-12-7-8(13)11-6-4-2-1-3-5(6)10-7/h1-4H,9H2,(H,10,12)(H,11,13)

SMILES Code

SC1=NC2=CC=CC=C2N=C1NN

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 192.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Kaur G, Reinhart RA, Monks A, Evans D, Morris J, Polley E, Teicher BA. Bromodomain and hedgehog pathway targets in small cell lung cancer. Cancer Lett. 2016 Feb 28;371(2):225-39. doi: 10.1016/j.canlet.2015.12.001. Epub 2015 Dec 10. PubMed PMID: 26683772; PubMed Central PMCID: PMC4738144. 2: Gavrish E, Shrestha B, Chen C, Lister I, North EJ, Yang L, Lee RE, Han A, Williams B, Charnuska D, Coleman K, Lewis K, LaFleur MD. In vitro and in vivo activities of HPi1, a selective antimicrobial against Helicobacter pylori. Antimicrob Agents Chemother. 2014 Jun;58(6):3255-60. doi: 10.1128/AAC.02573-13. Epub 2014 Mar 31. PubMed PMID: 24687512; PubMed Central PMCID: PMC4068456. 3: Liu G, Dou S, Akalin A, Rusckowski M, Streeter PR, Shultz LD, Greiner DL. Pretargeting vs. direct targeting of human betalox5 islet cells subcutaneously implanted in mice using an anti-human islet cell antibody. Nucl Med Biol. 2012 Jul;39(5):645-51. doi: 10.1016/j.nucmedbio.2011.12.001. Epub 2012 Feb 10. PubMed PMID: 22316614; PubMed Central PMCID: PMC3361517. 4: Liu G, Dou S, Cheng D, Leif J, Rusckowski M, Streeter PR, Shultz LD, Hnatowich DJ, Greiner DL. Human islet cell MORF/cMORF pretargeting in a xenogeneic murine transplant model. Mol Pharm. 2011 Jun 6;8(3):767-73. doi: 10.1021/mp100382m. Epub 2011 Apr 21. PubMed PMID: 21361360; PubMed Central PMCID: PMC3109173. 5: Yoshii T, Kuji N, Komatsu S, Iwahashi K, Tanaka Y, Yoshida H, Wada A, Yoshimura Y. Fine resolution of human sperm nucleoproteins by two-dimensional electrophoresis. Mol Hum Reprod. 2005 Sep;11(9):677-81. Epub 2005 Sep 28. PubMed PMID: 16192297. 6: Matesic LE, Niemitz EL, De Maio A, Reeves RH. Quantitative trait loci modulate neutrophil infiltration in the liver during LPS-induced inflammation. FASEB J. 2000 Nov;14(14):2247-54. PubMed PMID: 11053246. 7: Prigent Y, Troalen F, Dadoune JP. Immunoelectron microscopic visualization of intermediate basic proteins HPI1 and HPI2 in human spermatids and spermatozoa. Reprod Nutr Dev. 1998 Jul-Aug;38(4):417-27. PubMed PMID: 9795985. 8: Lin WY, Wang SJ, Yeh SH. Hepatic perfusion index in evaluating treatment effect of transcatheter hepatic artery embolization in patients with hepatocellular carcinoma. Neoplasma. 1995;42(2):89-92. PubMed PMID: 7617083. 9: Alimi E, Martinage A, Arkhis A, Belaiche D, Sautiere P, Chevaillier P. Amino acid sequence of the human intermediate basic protein 2 (HPI2) from sperm nuclei. Structural relationship with protamine P2. Eur J Biochem. 1993 Jun 1;214(2):445-50. PubMed PMID: 8513794. 10: Martinage A, Arkhis A, Alimi E, Sautière P, Chevaillier P. Molecular characterization of nuclear basic protein HPI1, a putative precursor of human sperm protamines HP2 and HP3. Eur J Biochem. 1990 Jul 31;191(2):449-51. PubMed PMID: 2384091. 11: Chevaillier P, Martinage A, Arkhis A, Sautière P. [Protamine precursors in human spermatozoa]. Reprod Nutr Dev. 1990;30(3):343-7. French. PubMed PMID: 2397030. 12: Journois D, Safran D, Castelain MH, Chanu D, Drévillon C, Barrier G. [Comparison of the antithrombotic effects of heparin, enoxaparin and prostacycline in continuous hemofiltration]. Ann Fr Anesth Reanim. 1990;9(4):331-7. French. PubMed PMID: 2169213.