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MedKoo Cat#: 413391 | Name: CV 6504

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CV 6504 is a dual inhibitor of thromboxane A2 synthetase and 5-lipoxygenase. It also possesses oxygen scavenging activity.

Chemical Structure

CV 6504
CV 6504
CAS#117574-40-0

Theoretical Analysis

MedKoo Cat#: 413391

Name: CV 6504

CAS#: 117574-40-0

Chemical Formula: C15H15NO2

Exact Mass: 241.1103

Molecular Weight: 241.29

Elemental Analysis: C, 74.67; H, 6.27; N, 5.81; O, 13.26

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CV 6504; CV-6504; CV6504
IUPAC/Chemical Name
2,5-Cyclohexadiene-1,4-dione, 2,3,5-trimethyl-6-(3-pyridinylmethyl)-
InChi Key
IPGAFOVEIIWXFR-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H15NO2/c1-9-10(2)15(18)13(11(3)14(9)17)7-12-5-4-6-16-8-12/h4-6,8H,7H2,1-3H3
SMILES Code
O=C1C(C)=C(C)C(C(C)=C1CC2=CC=CN=C2)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
Soluble in DMSO 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 241.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hussey HJ, Tisdale MJ. Metabolism and pharmacokinetics of the anti-tumour agent 2,3,5-trimethyl-6-(3-pyridylmethyl)1,4-benzoquinone (CV-6504). Br J Cancer. 1996 Nov;74(9):1349-53. doi: 10.1038/bjc.1996.548. PMID: 8912528; PMCID: PMC2074783. 2: Hussey HJ, Tisdale MJ. Mechanism of the anti-tumour effect of 2,3,5-trimethyl-6-(3-pyridylmethyl) 1,4-benzoquinone (CV-6504). Br J Cancer. 1997;75(6):845-9. doi: 10.1038/bjc.1997.150. PMID: 9062405; PMCID: PMC2063397. 3: Hussey HJ, Bibby MC, Tisdale MJ. Novel anti-tumour activity of 2,3,5-trimethyl-6-(3-pyridylmethyl)-1,4- benzoquinone (CV-6504) against established murine adenocarcinomas (MAC). Br J Cancer. 1996 May;73(10):1187-92. doi: 10.1038/bjc.1996.229. PMID: 8630277; PMCID: PMC2074504. 4: Terao S, Ohkawa S, Terashita Z, Shibouta Y, Nishikawa K. Synthesis and biological evaluation of 2,3,5-trimethyl-6-(3-pyridylmethyl)-1,4-benzoquinone (CV-6504), a dual inhibitor of TXA2 synthase and 5-lipoxygenase with scavenging activity of active oxygen species (AOS). Adv Prostaglandin Thromboxane Leukot Res. 1991;21A:173-6. PMID: 1847762. 5: Wyke SM, Khal J, Tisdale MJ. Signalling pathways in the induction of proteasome expression by proteolysis-inducing factor in murine myotubes. Cell Signal. 2005 Jan;17(1):67-75. doi: 10.1016/j.cellsig.2004.05.015. PMID: 15451026. 6: Whitehouse AS, Tisdale MJ. Downregulation of ubiquitin-dependent proteolysis by eicosapentaenoic acid in acute starvation. Biochem Biophys Res Commun. 2001 Jul 20;285(3):598-602. doi: 10.1006/bbrc.2001.5209. PMID: 11453634. 7: Ohkawa S, Terao S, Terashita Z, Shibouta Y, Nishikawa K. Dual inhibitors of thromboxane A2 synthase and 5-lipoxygenase with scavenging activity of active oxygen species. Synthesis of a novel series of (3-pyridylmethyl)benzoquinone derivatives. J Med Chem. 1991 Jan;34(1):267-76. doi: 10.1021/jm00105a042. PMID: 1992126. 8: Shibouta Y, Terashita Z, Imura Y, Shino A, Kawamura M, Ohtsuki K, Ohkawa S, Nishikawa K, Fujiwara Y. Involvement of thromboxane A2, leukotrienes and free radicals in puromycin nephrosis in rats. Kidney Int. 1991 May;39(5):920-9. doi: 10.1038/ki.1991.115. PMID: 2067208. 9: Ferry DR, Deakin M, Baddeley J, Daryanani S, Bramhall S, Anderson DA, Wakelam MJ, Doran J, Pemberton G, Young AM, Buckels J, Kerr DJ. A phase II study of the 5-lipoxygenase inhibitor, CV6504, in advanced pancreatic cancer: correlation of clinical data with pharmacokinetic and pharmacodynamic endpoints. Ann Oncol. 2000 Sep;11(9):1165-70. doi: 10.1023/a:1008303715515. PMID: 11061613. 10: Ohkawa S, Terao T, Murakami M, Matsumoto T, Goto G. Reduction of 2,3,5-trimethyl-6-(3-pyridylmethyl)-1,4-benzoquinone by PB-3c cells and biological activity of its hydroquinone. Chem Pharm Bull (Tokyo). 1991 Apr;39(4):917-21. doi: 10.1248/cpb.39.917. PMID: 1893498.

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