MedKoo Cat#: 563059 | Name: DTS

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DTS is a selective and isoform-specific RSK1 kinase inhibitor with broad cancer therapeutic potential.

Chemical Structure

DTS
DTS
CAS#6493-73-8

Theoretical Analysis

MedKoo Cat#: 563059

Name: DTS

CAS#: 6493-73-8

Chemical Formula: C14H14S3

Exact Mass: 278.0258

Molecular Weight: 278.44

Elemental Analysis: C, 60.39; H, 5.07; S, 34.54

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
DTS; Dibenzyl trisulfide;
IUPAC/Chemical Name
Bis(phenylmethyl)trisulfide
InChi Key
UXDMWYANCHMSJX-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H14S3/c1-3-7-13(8-4-1)11-15-17-16-12-14-9-5-2-6-10-14/h1-10H,11-12H2
SMILES Code
C1(CSSSCC2=CC=CC=C2)=CC=CC=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 278.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yagdi Efe E, Mazumder A, Lee JY, Gaigneaux A, Radogna F, Nasim MJ, Christov C, Jacob C, Kim KW, Dicato M, Chaimbault P, Cerella C, Diederich M. Tubulin-binding anticancer polysulfides induce cell death via mitotic arrest and autophagic interference in colorectal cancer. Cancer Lett. 2017 Dec 1;410:139-157. doi: 10.1016/j.canlet.2017.09.011. Epub 2017 Sep 21. PubMed PMID: 28943451. 2: Gutierrez RMP, Hoyo-Vadillo C. Anti-inflammatory Potential of Petiveria alliacea on Activated RAW264.7 Murine Macrophages. Pharmacogn Mag. 2017 Jul;13(Suppl 2):S174-S178. doi: 10.4103/pm.pm_479_16. Epub 2017 Jul 11. PubMed PMID: 28808377; PubMed Central PMCID: PMC5538151. 3: Murray J, Picking D, Lamm A, McKenzie J, Hartley S, Watson C, Williams L, Lowe H, Delgoda R. Significant inhibitory impact of dibenzyl trisulfide and extracts of Petiveria alliacea on the activities of major drug-metabolizing enzymes in vitro: An assessment of the potential for medicinal plant-drug interactions. Fitoterapia. 2016 Jun;111:138-46. doi: 10.1016/j.fitote.2016.04.011. Epub 2016 Apr 20. PubMed PMID: 27105957. 4: Lowe HI, Facey CO, Toyang NJ, Bryant JL. Specific RSK kinase inhibition by dibenzyl trisulfide and implication for therapeutic treatment of cancer. Anticancer Res. 2014 Apr;34(4):1637-41. PubMed PMID: 24692692. 5: Williams LA. Life's immunity as a normal distribution function: philosophies for the use of dibenzyl trisulphide in immunity enhancement and life extension. West Indian Med J. 2010 Oct;59(5):455. PubMed PMID: 21473388. 6: Pepple DJ, Richards AA, Lowe DA, Reid WA, Younger NO, Williams LA. In vitro erythrocytic membrane effects of dibenzyl trisulfide, a secondary metabolite of Petiveria alliacea. Fitoterapia. 2010 Dec;81(8):1113-6. doi: 10.1016/j.fitote.2010.07.006. Epub 2010 Jul 11. PubMed PMID: 20627119. 7: Williams LA, Barton EN, Kraus W, Rösner H. Implications of dibenzyl trisulphide for disease treatment based on its mode of action. West Indian Med J. 2009 Nov;58(5):407-9. PubMed PMID: 20441056. 8: Sharma PR, Shanmugavel M, Saxena AK, Qazi GN. Induction of apoptosis by a synergistic lignan composition from Cedrus deodara in human cancer cells. Phytother Res. 2008 Dec;22(12):1587-94. doi: 10.1002/ptr.2511. PubMed PMID: 19067377. 9: Williams LA, Rosner H, Levy HG, Barton EN. A critical review of the therapeutic potential of dibenzyl trisulphide isolated from Petiveria alliacea L (guinea hen weed, anamu). West Indian Med J. 2007 Jan;56(1):17-21. PubMed PMID: 17621839. 10: An H, Zhu J, Wang X, Xu X. Synthesis and anti-tumor evaluation of new trisulfide derivatives. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4826-9. Epub 2006 Jul 7. PubMed PMID: 16828553. 11: Williams LA, Rösner H, Möller W, Conrad J, Nkurunziza JP, Kraus W. In vitro anti-proliferation/cytotoxic activity of sixty natural products on the human SH-SY5Y neuroblastoma cells with specific reference to dibenzyl trisulphide. West Indian Med J. 2004 Sep;53(4):208-19. PubMed PMID: 15622673. 12: Cotton FA, Schmid G. Mononuclear Molybdenum(IV) Complexes with Two Multiply Bonded Chalcogen Ligands in Trans Configuration and Chelating Biphosphine Ligands. Inorg Chem. 1997 May 21;36(11):2267-2278. PubMed PMID: 11669860.