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MedKoo Cat#: 597125 | Name: Folic acid, methyl-

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Folic acid, methyl- is a nutrient that belongs to the vitamin B family. The body needs folate and cannot produce it on its own, so folate needs to be consumed in the diet or by supplementation. Folate is primarily responsible for the easy conversion of carbohydrates into glucose in our bodies. Folate is essential in red blood cell formation, cell division, detoxification and the production of some neurotransmitters. For this reason, folic acid is a supplement often prescribed to pregnant women to prevent certain birth defects.

Chemical Structure

Folic acid, methyl-
Folic acid, methyl-
CAS#70114-87-3

Theoretical Analysis

MedKoo Cat#: 597125

Name: Folic acid, methyl-

CAS#: 70114-87-3

Chemical Formula: C20H21N7O6

Exact Mass: 455.1553

Molecular Weight: 455.43

Elemental Analysis: C, 52.75; H, 4.65; N, 21.53; O, 21.08

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Folic acid, methyl-; x-Methyl folic acid; x-Methylfolic acid; x-Methylpteroylglutamic acid;
IUPAC/Chemical Name
(S)-2-(4-(((2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl)amino)benzamido)-5-methoxy-5-oxopentanoic acid
InChi Key
BNZPKFAGFVCCMO-ZDUSSCGKSA-N
InChi Code
1S/C20H21N7O6/c1-33-14(28)7-6-13(19(31)32)25-17(29)10-2-4-11(5-3-10)22-8-12-9-23-16-15(24-12)18(30)27-20(21)26-16/h2-5,9,13,22H,6-8H2,1H3,(H,25,29)(H,31,32)(H3,21,23,26,27,30)/t13-/m0/s1
SMILES Code
COC(CC[C@H](NC(c1ccc(NCc2nc3c(=O)nc(N)[nH]c3nc2)cc1)=O)C(O)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 455.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Servy EJ, Jacquesson-Fournols L, Cohen M, Menezo YJR. MTHFR isoform carriers. 5-MTHF (5-methyl tetrahydrofolate) vs folic acid: a key to pregnancy outcome: a case series. J Assist Reprod Genet. 2018 Jun 7. doi: 10.1007/s10815-018-1225-2. [Epub ahead of print] PubMed PMID: 29882091. 2: Henderson AM, Aleliunas RE, Loh SP, Khor GL, Harvey-Leeson S, Glier MB, Kitts DD, Green TJ, Devlin AM. l-5-Methyltetrahydrofolate Supplementation Increases Blood Folate Concentrations to a Greater Extent than Folic Acid Supplementation in Malaysian Women. J Nutr. 2018 Jun 1;148(6):885-890. doi: 10.1093/jn/nxy057. PubMed PMID: 29878267. 3: Ornoy A, Koren G, Yanai J. Is post exposure prevention of teratogenic damage possible: Studies on diabetes, valproic acid, alcohol and anti folates in pregnancy: Animal studies with reflection to human. Reprod Toxicol. 2018 May 31. pii: S0890-6238(18)30101-1. doi: 10.1016/j.reprotox.2018.05.006. [Epub ahead of print] Review. PubMed PMID: 29859881. 4: Ganassin R, Souza LR, Py-Daniel KR, Longo JPF, Coelho JM, Rodrigues MC, Jiang CS, Gu J, Morais PC, Mosiniewicz-Szablewska E, Suchocki P, Báo SN, Azevedo RB, Muehlmann LA. Decoration of a Poly(methyl vinyl ether-co-maleic anhydride)-Shelled Selol Nanocapsule with Folic Acid Increases Its Activity Against Different Cancer Cell Lines In Vitro. J Nanosci Nanotechnol. 2018 Jan 1;18(1):522-528. doi: 10.1166/jnn.2018.13974. PubMed PMID: 29768877. 5: Abbasi IHR, Abbasi F, Wang L, Abd El Hack ME, Swelum AA, Hao R, Yao J, Cao Y. Folate promotes S-adenosyl methionine reactions and the microbial methylation cycle and boosts ruminants production and reproduction. AMB Express. 2018 Apr 23;8(1):65. doi: 10.1186/s13568-018-0592-5. Review. PubMed PMID: 29687201; PubMed Central PMCID: PMC5913057. 6: Awwad HM, Ohlmann CH, Stoeckle M, Geisel J, Obeid R. Serum concentrations of folate vitamers in patients with a newly diagnosed prostate cancer or hyperplasia. Clin Biochem. 2018 Jun;56:41-46. doi: 10.1016/j.clinbiochem.2018.04.011. Epub 2018 Apr 16. PubMed PMID: 29673813. 7: Chen Y, Feng H, Chen D, Abuduwaili K, Li X, Zhang H. Protective effects of folic acid on DNA damage and DNA methylation levels induced by N-methyl- N'-nitro- N-nitrosoguanidine in Kazakh esophageal epithelial cells. Hum Exp Toxicol. 2018 Jan 1:960327118769709. doi: 10.1177/0960327118769709. [Epub ahead of print] PubMed PMID: 29644877. 8: İscan B, Tuzun F, Eroglu Filibeli B, Cilekar Micili S, Ergur BU, Duman N, Ozkan H, Kumral A. Effects of maternal folic acid supplementation on airway remodeling and allergic airway disease development. J Matern Fetal Neonatal Med. 2018 Mar 27:1-9. doi: 10.1080/14767058.2018.1452904. [Epub ahead of print] PubMed PMID: 29587542. 9: Padmanabhan N, Rakoczy J, Kondratowicz M, Menelaou K, Blake GET, Watson ED. Multigenerational analysis of sex-specific phenotypic differences at midgestation caused by abnormal folate metabolism. Environ Epigenet. 2017 Nov 3;3(4):dvx014. doi: 10.1093/eep/dvx014. eCollection 2017 Oct. PubMed PMID: 29492317; PubMed Central PMCID: PMC5804557. 10: Cao Y, He J, Liu J, Zhang M, Ni P. Folate-Conjugated Polyphosphoester with Reversible Cross-Linkage and Reduction Sensitivity for Drug Delivery. ACS Appl Mater Interfaces. 2018 Mar 7;10(9):7811-7820. doi: 10.1021/acsami.7b18887. Epub 2018 Feb 20. PubMed PMID: 29431989. 11: Campos-Giménez E, Bénet S, Oguey Y, Martin F, Redeuil K. The contribution of minor folates to the total vitamin B9 content of Infant formula and clinical nutrition products. Food Chem. 2018 May 30;249:91-97. doi: 10.1016/j.foodchem.2017.12.061. Epub 2017 Dec 16. PubMed PMID: 29407937. 12: Kasulanati S, Venkatesan V. Understanding pluripotency under folic acid deficiency using embryonic stem cells as an in vitro model. Med Hypotheses. 2018 Feb;111:24-26. doi: 10.1016/j.mehy.2017.12.019. Epub 2017 Dec 14. PubMed PMID: 29406990. 13: Moura CM, Bastos PR, Ribeiro JSV, Ribeiro MG, Amorim MR, Costa-Lima MA. DNA (cytosine-5)-methyltransferase 3B (DNMT 3B) polymorphism and risk of Down syndrome offspring. Saudi J Biol Sci. 2018 Jan;25(1):101-104. doi: 10.1016/j.sjbs.2017.09.008. Epub 2017 Sep 27. PubMed PMID: 29379364; PubMed Central PMCID: PMC5775107. 14: Morscher RJ, Ducker GS, Li SH, Mayer JA, Gitai Z, Sperl W, Rabinowitz JD. Mitochondrial translation requires folate-dependent tRNA methylation. Nature. 2018 Feb 1;554(7690):128-132. doi: 10.1038/nature25460. Epub 2018 Jan 24. PubMed PMID: 29364879. 15: Liu G, Bin P, Wang T, Ren W, Zhong J, Liang J, Hu CA, Zeng Z, Yin Y. DNA Methylation and the Potential Role of Methyl-Containing Nutrients in Cardiovascular Diseases. Oxid Med Cell Longev. 2017;2017:1670815. doi: 10.1155/2017/1670815. Epub 2017 Nov 16. Review. PubMed PMID: 29348786; PubMed Central PMCID: PMC5733941. 16: Stracquadanio M, Ciotta L, Palumbo MA. Effects of myo-inositol, gymnemic acid, and L-methylfolate in polycystic ovary syndrome patients. Gynecol Endocrinol. 2018 Jun;34(6):495-501. doi: 10.1080/09513590.2017.1418852. Epub 2017 Dec 21. PubMed PMID: 29265900. 17: Cui S, Li W, Wang P, Lv X, Gao Y, Huang G. Folic acid inhibits homocysteine-induced cell apoptosis in human umbilical vein endothelial cells. Mol Cell Biochem. 2018 Jul;444(1-2):77-86. doi: 10.1007/s11010-017-3232-5. Epub 2017 Dec 18. PubMed PMID: 29250709. 18: Vishnumohan S, Pickford R, Arcot J. Naturally occurring folates in selected traditionally prepared foods in Southern India. J Food Sci Technol. 2017 Dec;54(13):4173-4180. doi: 10.1007/s13197-017-2870-7. Epub 2017 Oct 10. PubMed PMID: 29184222; PubMed Central PMCID: PMC5685996. 19: Leung KY, Pai YJ, Chen Q, Santos C, Calvani E, Sudiwala S, Savery D, Ralser M, Gross SS, Copp AJ, Greene NDE. Partitioning of One-Carbon Units in Folate and Methionine Metabolism Is Essential for Neural Tube Closure. Cell Rep. 2017 Nov 14;21(7):1795-1808. doi: 10.1016/j.celrep.2017.10.072. PubMed PMID: 29141214; PubMed Central PMCID: PMC5699646. 20: Ceborska M, Zimnicka M, Kowalska AA, Dąbrowa K, Repeć B. Structural diversity in the host-guest complexes of the antifolate pemetrexed with native cyclodextrins: gas phase, solution and solid state studies. Beilstein J Org Chem. 2017 Oct 25;13:2252-2263. doi: 10.3762/bjoc.13.222. eCollection 2017. PubMed PMID: 29114329; PubMed Central PMCID: PMC5669224.

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