MedKoo Cat#: 597119 | Name: Emideltide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Emideltide, also known as delta sleep-inducing peptide (DSIP), is a nonapeptide composed of nine amino acids. It is found in neurons, peripheral organs, and plasma. This neuropeptide primarily induces delta sleep in mammals. Beyond its role in sleep, emideltide has been observed to affect electrophysiological activity, neurotransmitter levels in the brain, circadian and locomotor patterns, hormonal levels, psychological performance, and the activity of neuropharmacological drugs, including their withdrawal.

Chemical Structure

Emideltide
Emideltide
CAS#62568-57-4 (free)

Theoretical Analysis

MedKoo Cat#: 597119

Name: Emideltide

CAS#: 62568-57-4 (free)

Chemical Formula: C35H48N10O15

Exact Mass: 848.3301

Molecular Weight: 848.82

Elemental Analysis: C, 49.53; H, 5.70; N, 16.50; O, 28.27

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Synonym
Emideltide; DSIP; DSIP nonapeptide; Delta sleep inducing peptide; Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu;
IUPAC/Chemical Name
(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-[[(2S)-2-amino-3-(1H-indol-3-yl)propanoyl]amino]propanoyl]amino]acetyl]amino]acetyl]amino]-3-carboxypropanoyl]amino]propanoyl]amino]-3-hydroxypropanoyl]amino]acetyl]amino]pentanedioic acid
InChi Key
ZRZROXNBKJAOKB-GFVHOAGBSA-N
InChi Code
InChI=1S/C35H48N10O15/c1-16(41-32(56)20(36)9-18-11-37-21-6-4-3-5-19(18)21)30(54)39-12-25(47)38-13-26(48)44-23(10-29(52)53)34(58)42-17(2)31(55)45-24(15-46)33(57)40-14-27(49)43-22(35(59)60)7-8-28(50)51/h3-6,11,16-17,20,22-24,37,46H,7-10,12-15,36H2,1-2H3,(H,38,47)(H,39,54)(H,40,57)(H,41,56)(H,42,58)(H,43,49)(H,44,48)(H,45,55)(H,50,51)(H,52,53)(H,59,60)/t16-,17-,20-,22-,23-,24-/m0/s1
SMILES Code
O=C(O)CC[C@@H](C(O)=O)NC(CNC([C@H](CO)NC([C@H](C)NC([C@H](CC(O)=O)NC(CNC(CNC([C@H](C)NC([C@H](CC1=CNC2=C1C=CC=C2)N)=O)=O)=O)=O)=O)=O)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 848.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Cui L, Ma Y, Li M, Wei Z, Huan Y, Fei Q, Li H, Zheng L. An acidic residue reactive and disulfide bond-containing cleavable cross-linker for probing protein 3D structures based on electrochemical mass spectrometry. Talanta. 2020 Aug 15;216:120964. doi: 10.1016/j.talanta.2020.120964. Epub 2020 Apr 3. PMID: 32456912.