Synonym
4-Methoxybiphenyl; NSC 3793; NSC-3793; NSC3793;
IUPAC/Chemical Name
4-Methoxy-1,1'-biphenyl
InChi Key
RHDYQUZYHZWTCI-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H12O/c1-14-13-9-7-12(8-10-13)11-5-3-2-4-6-11/h2-10H,1H3
SMILES Code
COC1=CC=C(C2=CC=CC=C2)C=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
184.24
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Lau PL, Allen RW, Styring P. Continuous-flow Heck synthesis of 4-methoxybiphenyl and methyl 4-methoxycinnamate in supercritical carbon dioxide expanded solvent solutions. Beilstein J Org Chem. 2013 Dec 17;9:2886-97. doi: 10.3762/bjoc.9.325. eCollection 2013. PubMed PMID: 24367454; PubMed Central PMCID: PMC3869343.
2: Tsutsumi T, Amakura Y, Okuyama A, Tanioka Y, Sakata K, Sasaki K, Maitani T. Application of an ELISA for PCB 118 to the screening of dioxin-like PCBs in retail fish. Chemosphere. 2006 Oct;65(3):467-73. Epub 2006 Mar 10. PubMed PMID: 16530250.
3: Glaser R, Knotts N, Wu Z, Barnes CL. Dipole Parallel-Alignment in the Crystal Structure of a Polar Biphenyl: 4'-Acetyl-4-Methoxybiphenyl (AMB). Cryst Growth Des. 2006;6(1):235-240. PubMed PMID: 19169419; PubMed Central PMCID: PMC2630165.
4: Lehmler HJ, Parkin S, Robertson LW. The three-dimensional structure of 3, 3', 5'-trichloro-4-methoxybiphenyl, a "coplanar" polychlorinated biphenyl (PCB) derivative. Chemosphere. 2002 Jan;46(3):485-8. PubMed PMID: 11829405.
5: Chandra A, Nair MG. Supercritical carbon dioxide extraction and quantification of bioactive neolignans from Magnolia virginiana flowers. Planta Med. 1995 Apr;61(2):192-5. PubMed PMID: 7753933.
6: Fry JR, Paterson P. Influence of the sulphation inhibitor, 2,6-dichloro-4-nitrophenol, on the production and conjugation, of 4-hydroxybiphenyl generated from 4-methoxybiphenyl by rat isolated hepatocytes. Biochem Pharmacol. 1987 Sep 15;36(18):3090-2. PubMed PMID: 3632729.
7: Fry JR. Influence of substrate concentration on the phase I and phase II metabolism of 4-methoxybiphenyl by rat isolated hepatocytes. Xenobiotica. 1987 Jun;17(6):751-8. PubMed PMID: 3630209.
8: Paterson P, Fry JR. Influence of cytochrome P-450 type on the pattern of conjugation of 4-hydroxybiphenyl generated from biphenyl or 4-methoxybiphenyl. Xenobiotica. 1985 Jun;15(6):493-502. PubMed PMID: 4036173.
9: Paterson P, Fry JR. The effect of ascorbic acid on the conjugation of 4-hydroxybiphenyl in rat isolated hepatocytes. Xenobiotica. 1983 Oct;13(10):607-10. PubMed PMID: 6673373.
10: Smith RV, Milton SA, Davis PJ. Microbial models of mammalian metabolism: O-dealkylation of para-alkoxybiphenyls. Appl Environ Microbiol. 1982 Jul;44(1):149-52. PubMed PMID: 6812499; PubMed Central PMCID: PMC241982.
11: Clark AM, El-Feraly FS, Li WS. Antimicrobial activity of phenolic constituents of Magnolia grandiflora L. J Pharm Sci. 1981 Aug;70(8):951-2. PubMed PMID: 7310672.
12: Fry JR. A comparison of biphenyl 4-hydroxylation and 4-methoxybiphenyl O-demethylation in rat liver microsomes. Biochem Pharmacol. 1981 Jul 15;30(14):1915-9. PubMed PMID: 7271882.
13: Maass WS, Hutzinger O. Metabolism of 4-chlorobiphenyl by lichens. Arch Environ Contam Toxicol. 1975-1976;3(4):470-8. PubMed PMID: 816260.
14: Bridges JW, Creaven PJ, Williams RT. The fluorescence of some biphenyl derivatives. Biochem J. 1965 Sep;96(3):872-8. PubMed PMID: 5862424; PubMed Central PMCID: PMC1207230.
