Isatoribine free base | CAS#122970-40-5 | TLR7 agonist

MedKoo Cat#: 584460 | Name: Isatoribine free base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Isatoribine (also known as immunosine, or 7-thia-8-oxoguanosine) is a novel guanosine analogue showing immunostimulatory activity both in vivo and in vitro. This compound acts on different components of the immune system including B cells, natural killer (NK) cells and antigen-presenting cells (APC). It was found that immunosine significantly stimulates proliferation of T cells. The effect was dose-dependent and also depended on concentrations of specific stimulators. Maximal stimulation was seen using 250 microM immunosine.

Chemical Structure

Isatoribine free base

CAS#122970-40-5 (free base)

Theoretical Analysis

MedKoo Cat#: 584460

Name: Isatoribine free base

CAS#: 122970-40-5 (free base)

Chemical Formula: C10H12N4O6S

Exact Mass: 316.0478

Molecular Weight: 316.29

Elemental Analysis: C, 37.97; H, 3.82; N, 17.71; O, 30.35; S, 10.14

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

198832-38-1 (hydrate) 122970-40-5 (free base)

Synonym

ANA245; ANA-245; ANA 245; Immusine; Isatoribine; Isatoribine monohydrate; D04619; 7-thia-8-oxoguanosine.

IUPAC/Chemical Name

Thiazolo(4,5-d)pyrimidine-2,7(3H,4H)-dione, 5-amino-3-beta-D-ribofuranosyl-

InChi Key

TZYVRXZQAWPIAB-FCLHUMLKSA-N

InChi Code

InChI=1S/C10H12N4O6S/c11-9-12-6-5(7(18)13-9)21-10(19)14(6)8-4(17)3(16)2(1-15)20-8/h2-4,8,15-17H,1H2,(H3,11,12,13,18)/t2-,3-,4-,8-/m1/s1

SMILES Code

O=C(N1[C@H]2[C@@H]([C@@H]([C@@H](CO)O2)O)O)SC3=C1NC(N)=NC3=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 316.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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