Gallopamil HCl, (-)- | CAS#36622-39-6 | L-type calcium channel blocker

MedKoo Cat#: 597086 | Name: Gallopamil HCl, (-)-

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Gallopamil HCl, (-)- is an L-type calcium channel blocker that is an analog of verapamil. It is used in the treatment of abnormal heart rhythms.

Chemical Structure

Gallopamil HCl, (-)-

CAS#36622-39-6 (HCl - rotation)

Theoretical Analysis

MedKoo Cat#: 597086

Name: Gallopamil HCl, (-)-

CAS#: 36622-39-6 (HCl - rotation)

Chemical Formula: C28H41ClN2O5

Exact Mass: 0.0000

Molecular Weight: 521.09

Elemental Analysis: C, 64.54; H, 7.93; Cl, 6.80; N, 5.38; O, 15.35

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

16662-47-8 (free base) 16662-46-7 (HCl) 36622-39-6 (HCl - rotation) 36622-40-9 (free base - rotation) 38176-09-9 (HCl + rotation) 38176-10-2(free base + rotation)

Synonym

Gallopamil hydrochloride, (-)-; (S)-Gallopamil hydrochloride; (-)-Gallopamil hydrochloride; L-Gallopamil hydrochloride;

IUPAC/Chemical Name

(S)-5-((3,4-dimethoxyphenethyl)(methyl)amino)-2-isopropyl-2-(3,4,5-trimethoxyphenyl)pentanenitrile hydrochloride

InChi Key

OKCRIUNHEQSXFD-JCOPYZAKSA-N

InChi Code

InChI=1S/C28H40N2O5.ClH/c1-20(2)28(19-29,22-17-25(33-6)27(35-8)26(18-22)34-7)13-9-14-30(3)15-12-21-10-11-23(31-4)24(16-21)32-5;/h10-11,16-18,20H,9,12-15H2,1-8H3;1H/t28-;/m0./s1

SMILES Code

N#C[C@](C1=CC(OC)=C(OC)C(OC)=C1)(C(C)C)CCCN(CCC2=CC=C(OC)C(OC)=C2)C.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 521.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Holohean AM, Hackman JC. Mechanisms intrinsic to 5-HT2B receptor-induced potentiation of NMDA receptor responses in frog motoneurones. Br J Pharmacol. 2004 Oct;143(3):351-60. Epub 2004 Aug 31. PubMed PMID: 15339859; PubMed Central PMCID: PMC1575347. 2: Rustichelli C, Gamberini MC, Ferioli V, Gamberini G. Properties of the racemic species of verapamil hydrochloride and gallopamil hydrochloride. Int J Pharm. 1999 Feb 1;178(1):111-20. PubMed PMID: 10205631. 3: Gross AS, Mikus G, Ratge D, Wisser H, Eichelbaum M. Pharmacokinetics and pharmacodynamics of the enantiomers of gallopamil. J Pharmacol Exp Ther. 1997 Jun;281(3):1102-12. PubMed PMID: 9190842. 4: Schröder F, Herzig S. Pattern of interaction between dihydropyridine calcium antagonists and cationic amphiphilic drugs in isolated guinea-pig left atria. Arzneimittelforschung. 1993 Nov;43(11):1148-51. PubMed PMID: 8292056. 5: Stein G, Srivastava MK, Merker HJ, Neubert D. Effects of calcium channel blockers on the development of early rat postimplantation embryos in culture. Arch Toxicol. 1990;64(8):623-38. PubMed PMID: 2090030. 6: Bates MD, Conn PM. Calcium mobilization in the pituitary gonadotrope: relative roles of intra- and extracellular sources. Endocrinology. 1984 Oct;115(4):1380-5. PubMed PMID: 6383788. 7: Saunders MJ, Hepler PK. Calcium antagonists and calmodulin inhibitors block cytokinin-induced bud formation in Funaria. Dev Biol. 1983 Sep;99(1):41-9. PubMed PMID: 6618003. 8: Jørgensen F. Influence of Ca2+ on the mechanosensitivity of the hair cells in the lateral line organs of Necturus maculosus. Acta Physiol Scand. 1983 Aug;118(4):423-31. PubMed PMID: 6314749.