MedKoo Cat#: 597066 | Name: L-Eflornithine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

L-Eflornithine is a medication used to treat African trypanosomiasis (sleeping sickness) and excessive hair growth on the face in women. Specifically it is used for the 2nd stage of sleeping sickness caused by T. b. gambiense and may be used with nifurtimox.

Chemical Structure

L-Eflornithine
L-Eflornithine
CAS#66640-93-5 (L-isomer)

Theoretical Analysis

MedKoo Cat#: 597066

Name: L-Eflornithine

CAS#: 66640-93-5 (L-isomer)

Chemical Formula: C6H12F2N2O2

Exact Mass: 182.0867

Molecular Weight: 182.17

Elemental Analysis: C, 39.56; H, 6.64; F, 20.86; N, 15.38; O, 17.56

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
70052-12-9 (free base) 96020-91-6 (HCl hydrate) 68278-23-9 (HCl) 69955-42-6 (S-isomer) 70050-55-4 (R-isomer) 66640-93-5 (L-isomer)
Synonym
L-Eflornithine; L-alpha-Difluoromethylornithine; (-)-2-Difluoromethylornithine;
IUPAC/Chemical Name
(S)-2,5-diamino-2-(difluoromethyl)pentanoic acid
InChi Key
VLCYCQAOQCDTCN-ZCFIWIBFSA-N
InChi Code
InChI=1S/C6H12F2N2O2/c7-4(8)6(10,5(11)12)2-1-3-9/h4H,1-3,9-10H2,(H,11,12)/t6-/m1/s1
SMILES Code
N[C@](CCCN)(C(F)F)C(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 182.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Jansson-Löfmark R, Na-Bangchang K, Björkman S, Doua F, Ashton M. Enantiospecific reassessment of the pharmacokinetics and pharmacodynamics of oral eflornithine against late-stage Trypanosoma brucei gambiense sleeping sickness. Antimicrob Agents Chemother. 2015 Feb;59(2):1299-307. doi: 10.1128/AAC.04101-14. Epub 2014 Dec 15. PubMed PMID: 25512417; PubMed Central PMCID: PMC4335853. 2: Eozenou P, Jannin J, Ngampo S, Carme B, Tell GP, Schechter PJ. [A trial treatment with eflornithine of trypanosomiasis caused by Trypanosoma brucei gambiense in the Peoples Republic of the Congo]. Med Trop (Mars). 1989 Apr-Jun;49(2):149-54. French. PubMed PMID: 2507863.