Tolypomycin Y | CAS#23412-26-2 | bioactive chemical

MedKoo Cat#: 597063 | Name: Tolypomycin Y

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tolypomycin Y is naturally occurring ansamycin antibiotics.

Chemical Structure

Tolypomycin Y

CAS#23412-26-2

Theoretical Analysis

MedKoo Cat#: 597063

Name: Tolypomycin Y

CAS#: 23412-26-2

Chemical Formula: C43H54N2O14

Exact Mass: 822.3575

Molecular Weight: 822.90

Elemental Analysis: C, 62.76; H, 6.61; N, 3.40; O, 27.22

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Tolypomycin Y; NSC 177383; NSC-177383; NSC177383; B-2847-Y;

IUPAC/Chemical Name

4,6-Epoxy-1,2,3-methanobenzo(d)cycloprop(n)(1,9)oxaazacyclotetracosine-5,18,21,26(6H)-tetrone, 12-(acetyloxy)-10,11,12,13,14,15,16,16a,17,17a,22,25-dodecahydro-2,14,16-trihydroxy-10-methoxy-3,6,11,13,15,20-hexamethyl-25-((tetrahydro-6-hydroxy-2-methyl-2H-pyran-3-yl)imino)-, (6S-(6R*,8E,10R*,11S*,12R*,13S*,14S8,15S*,16R*,16aR*,17aS*,19Z,25(2R*,3S*,6R*)))-

InChi Key

RYCBEGMWBUYSAD-LGEIFLOZSA-N

InChi Code

InChI=1S/C43H54N2O14/c1-17-14-29(47)24-15-25(24)36(50)19(3)35(49)20(4)39(58-23(7)46)18(2)30(55-9)12-13-56-43(8)41(53)34-32-27(44-26-10-11-31(48)57-22(26)6)16-28(45-42(17)54)38(52)33(32)37(51)21(5)40(34)59-43/h12-14,16,18-20,22,24-26,30-31,35-36,39,48-51H,10-11,15H2,1-9H3,(H,45,54)/b13-12+,17-14+,44-27+/t18-,19+,20-,22+,24-,25-,26-,30-,31+,35-,36-,39-,43+/m1/s1

SMILES Code

O=C(C(NC(/C(C)=C/C([C@H]1[C@@H](C1)[C@@H]([C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@H](OC)/C=C/O[C@@](C)(O2)C3=O)O)=O)=O)=C/4)c5c(O)c(C)c2c3c5C4=N\[C@H]6[C@H](C)O[C@H](O)CC6

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 822.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Marshall VP, Cialdella JI, Ohlmann GM, Gray GD. MIC values do not predict the intraphagocytic killing of Staphylococcus aureus by naphthalenic ansamycins. J Antibiot (Tokyo). 1983 Nov;36(11):1549-60. PubMed PMID: 6140253. 2: Stanzani L, Venturini AP, Mantovani V. A new tolypomycin-Y derivative: in vitro and in vivo antimicrobial activity. J Antibiot (Tokyo). 1978 Nov;31(11):1195-200. PubMed PMID: 721713. 3: Bellomo P, Brufani M, Marchi E, Mascellani G, Melloni W, Montecchi L, Stanzani L. Synthesis and antibacterial activity of some derivatives of tolypomycinone. Relationship between structure and activity in ansamycins. J Med Chem. 1977 Oct;20(10):1287-91. PubMed PMID: 333113. 4: Hasegawa T. Tolypomycin, a new antibiotic. VII. Assay method for tolypomycin Y. J Antibiot (Tokyo). 1972 Jan;25(1):25-9. PubMed PMID: 5010642. 5: Kishi T, Yamana H, Muroi M, Harada S, Asai M. Tolypomycin, a new antibiotic. 3. Isolation and characterization of tolypomycin Y. J Antibiot (Tokyo). 1972 Jan;25(1):11-5. PubMed PMID: 4622052. 6: Hasegawa T, Higashide E, Shibata M. Tolypomycin, a new antibiotic. II. Production and preliminary identification of tolypomycin Y. J Antibiot (Tokyo). 1971 Dec;24(12):817-22. PubMed PMID: 5140529. 7: Kishi T, Harada S, Asai M, Muroi M, Mizuno K. Tolypomycin. II. Structures of tolyposamine and tolypomycin Y. Tetrahedron Lett. 1969 Jan;(2):97-100. PubMed PMID: 5766972.