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MedKoo Cat#: 597030 | Name: Di(dansyl)cystine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Di(dansyl)cystine is a fluorescent label for tropomyosin.

Chemical Structure

Di(dansyl)cystine
CAS#18468-46-7

Theoretical Analysis

MedKoo Cat#: 597030

Name: Di(dansyl)cystine

CAS#: 18468-46-7

Chemical Formula: C30H34N4O8S4

Exact Mass: 706.1259

Molecular Weight: 706.86

Elemental Analysis: C, 50.98; H, 4.85; N, 7.93; O, 18.11; S, 18.14

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Di(dansyl)cystine; Didansylcystine;
IUPAC/Chemical Name
S-(((R)-2-carboxy-2-((5-(dimethylamino)naphthalene)-1-sulfonamido)ethyl)thio)-N-((5-(dimethylamino)naphthalen-1-yl)sulfonyl)-D-cysteine
InChi Key
MGNAZESEUVNMRR-PSWAGMNNSA-N
InChi Code
InChI=1S/C30H34N4O8S4/c1-33(2)25-13-5-11-21-19(25)9-7-15-27(21)45(39,40)31-23(29(35)36)17-43-44-18-24(30(37)38)32-46(41,42)28-16-8-10-20-22(28)12-6-14-26(20)34(3)4/h5-16,23-24,31-32H,17-18H2,1-4H3,(H,35,36)(H,37,38)/t23-,24+
SMILES Code
O=C(O)[C@H](CSSC[C@H](C(O)=O)NS(=O)(C1=C2C=CC=C(N(C)C)C2=CC=C1)=O)NS(=O)(C3=C4C=CC=C(N(C)C)C4=CC=C3)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 706.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Levin G, Shirvan A, Grimberg H, Reshef A, Yogev-Falach M, Cohen A, Ziv I. Novel fluorescence molecular imaging of chemotherapy-induced intestinal apoptosis. J Biomed Opt. 2009 Sep-Oct;14(5):054019. doi: 10.1117/1.3253303. Erratum in: J Biomed Opt. 2011 Oct;16(10):109802. PubMed PMID: 19895121. 2: Reshef A, Shirvan A, Shohami E, Grimberg H, Levin G, Cohen A, Trembovler V, Ziv I. Targeting cell death in vivo in experimental traumatic brain injury by a novel molecular probe. J Neurotrauma. 2008 Jun;25(6):569-80. doi: 10.1089/neu.2007.0341. PubMed PMID: 18447626. 3: Cohen A, Ziv I, Aloya T, Levin G, Kidron D, Grimberg H, Reshef A, Shirvan A. Monitoring of chemotherapy-induced cell death in melanoma tumors by N,N'-Didansyl-L-cystine. Technol Cancer Res Treat. 2007 Jun;6(3):221-34. Erratum in: Technol Cancer Res Treat. 2011 Dec;10(6):625. PubMed PMID: 17535031. 4: Reshef A, Shirvan A, Grimberg H, Levin G, Cohen A, Mayk A, Kidron D, Djaldetti R, Melamed E, Ziv I. Novel molecular imaging of cell death in experimental cerebral stroke. Brain Res. 2007 May 4;1144:156-64. Epub 2007 Feb 1. Erratum in: Brain Res. 2012 Jan 6;1429:164. PubMed PMID: 17328873. 5: Damianovich M, Ziv I, Heyman SN, Rosen S, Shina A, Kidron D, Aloya T, Grimberg H, Levin G, Reshef A, Bentolila A, Cohen A, Shirvan A. ApoSense: a novel technology for functional molecular imaging of cell death in models of acute renal tubular necrosis. Eur J Nucl Med Mol Imaging. 2006 Mar;33(3):281-91. Epub 2005 Nov 29. Erratum in: Eur J Nucl Med Mol Imaging. 2011 Dec;38(12):2287. PubMed PMID: 16317537; PubMed Central PMCID: PMC1998881. 6: Daly TJ, Olson JS, Matthews KS. Formation of mixed disulfide adducts at cysteine-281 of the lactose repressor protein affects operator and inducer binding parameters. Biochemistry. 1986 Sep 23;25(19):5468-74. PubMed PMID: 3535878. 7: Lehrer SS, Betteridge DR, Graceffa P, Wong S, Seidel JC. Comparison of the fluorescence and conformational properties of smooth and striated tropomyosin. Biochemistry. 1984 Apr 10;23(8):1591-5. PubMed PMID: 6722112. 8: Betteridge DR, Lehrer SS. Two conformational states of didansylcystine-labeled rabbit cardiac tropomyosin. J Mol Biol. 1983 Jun 25;167(2):481-96. PubMed PMID: 6864806.