Gusacitinib, also known as ASN-002 and EN-3351, is a potent dual inhibitor of SYK/JAK kinases. ASN002 showed strong antitumor activity in both hematological and solid tumor xenograft models. ASN002 strongly suppressed the SYK and JAK family kinase signaling pathways as measured in pLAT and pSTAT assays, respectively. When profiled in a panel of 178 cell lines, ASN002 showed strong anti-proliferative activity in many lymphoid/leukemia cell lines, including SU-DHL-6, SU-DHL-4, OCI-LY10, H929 and Pfeiffer.
MedKoo Cat#: 206866
Name: Gusacitinib
CAS#: 1425381-60-7 (free base)
Chemical Formula: C24H28N8O2
Exact Mass: 460.2335
Molecular Weight: 460.54
Elemental Analysis: C, 62.59; H, 6.13; N, 24.33; O, 6.95
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 100.0 | 217.14 |
The following data is based on the product molecular weight 460.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
