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MedKoo Cat#: 563021 | Name: Creatine riboside
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Creatine riboside (CR) is a novel metabolite of cancer metabolism. It is a urinary diagnostic biomarker of lung and liver cancer risk and prognosis. The level of CR is highly positive correlated in tumor and urine indicating that it is derived from human lung and liver cancers.

Chemical Structure

Creatine riboside
Creatine riboside
CAS#1616693-92-5 (riboside)

Theoretical Analysis

MedKoo Cat#: 563021

Name: Creatine riboside

CAS#: 1616693-92-5 (riboside)

Chemical Formula: C9H17N3O6

Exact Mass: 263.1117

Molecular Weight: 263.25

Elemental Analysis: C, 41.06; H, 6.51; N, 15.96; O, 36.46

Price and Availability

Size Price Availability Quantity
50mg USD 750.00 2 Weeks
100mg USD 1,150.00 2 Weeks
200mg USD 1,850.00 2 Weeks
500mg USD 2,850.00 2 Weeks
1g USD 3,850.00 2 Weeks
2g USD 5,950.00 2 Weeks
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Related CAS #
57-00-1 (free) 15366-29-7 (ethyl ester) 67-07-2 (phosphate) 1616693-92-5 (riboside)
Synonym
Creatine riboside;
IUPAC/Chemical Name
N-(N-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)carbamimidoyl)-N-methylglycine
InChi Key
BGJFEKXALPJEGN-XVFCMESISA-N
InChi Code
InChI=1S/C9H17N3O6/c1-12(2-5(14)15)9(10)11-8-7(17)6(16)4(3-13)18-8/h4,6-8,13,16-17H,2-3H2,1H3,(H2,10,11)(H,14,15)/t4-,6-,7-,8-/m1/s1
SMILES Code
OC[C@H]1O[C@@H](NC(N(CC(O)=O)C)=N)[C@H](O)[C@@H]1O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 263.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Parker AL, Toulabi L, Oike T, Kanke Y, Patel D, Tada T, Taylor S, Beck JA, Bowman E, Reyzer ML, Butcher D, Kuhn S, Pauly GT, Krausz KW, Gonzalez FJ, Hussain SP, Ambs S, Ryan BM, Wang XW, Harris CC. Creatine riboside is a cancer cell-derived metabolite associated with arginine auxotrophy. J Clin Invest. 2022 Jul 15;132(14):e157410. doi: 10.1172/JCI157410. PMID: 35838048; PMCID: PMC9282934. 2: Oike T, Osu N, Yoshimoto Y, Obinata H, Yoshikawa K, Harris CC, Ohno T. Pilot study of plasma creatine riboside as a potential biomarker for cervical cancer. Heliyon. 2023 May 25;9(6):e16684. doi: 10.1016/j.heliyon.2023.e16684. PMID: 37292314; PMCID: PMC10245246. 3: Patel DP, Pauly GT, Tada T, Parker AL, Toulabi L, Kanke Y, Oike T, Krausz KW, Gonzalez FJ, Harris CC. Improved detection and precise relative quantification of the urinary cancer metabolite biomarkers - Creatine riboside, creatinine riboside, creatine and creatinine by UPLC-ESI-MS/MS: Application to the NCI- Maryland cohort population controls and lung cancer cases. J Pharm Biomed Anal. 2020 Nov 30;191:113596. doi: 10.1016/j.jpba.2020.113596. Epub 2020 Sep 1. PMID: 32937240; PMCID: PMC7756200. 4: Patel D, Thompson MD, Manna SK, Krausz KW, Zhang L, Nilubol N, Gonzalez FJ, Kebebew E. Unique and Novel Urinary Metabolomic Features in Malignant versus Benign Adrenal Neoplasms. Clin Cancer Res. 2017 Sep 1;23(17):5302-5310. doi: 10.1158/1078-0432.CCR-16-3156. Epub 2017 Apr 27. PMID: 28450405; PMCID: PMC5581680. 5: Haznadar M, Diehl CM, Parker AL, Krausz KW, Bowman ED, Rabibhadana S, Forgues M, Bhudhisawasdi V, Gonzalez FJ, Mahidol C, Budhu A, Wang XW, Ruchirawat M, Harris CC. Urinary Metabolites Diagnostic and Prognostic of Intrahepatic Cholangiocarcinoma. Cancer Epidemiol Biomarkers Prev. 2019 Oct;28(10):1704-1711. doi: 10.1158/1055-9965.EPI-19-0453. Epub 2019 Jul 29. PMID: 31358519; PMCID: PMC6774833. 6: Mathé EA, Patterson AD, Haznadar M, Manna SK, Krausz KW, Bowman ED, Shields PG, Idle JR, Smith PB, Anami K, Kazandjian DG, Hatzakis E, Gonzalez FJ, Harris CC. Noninvasive urinary metabolomic profiling identifies diagnostic and prognostic markers in lung cancer. Cancer Res. 2014 Jun 15;74(12):3259-70. doi: 10.1158/0008-5472.CAN-14-0109. Epub 2014 Apr 15. PMID: 24736543; PMCID: PMC4100625. 7: Haznadar M, Cai Q, Krausz KW, Bowman ED, Margono E, Noro R, Thompson MD, Mathé EA, Munro HM, Steinwandel MD, Gonzalez FJ, Blot WJ, Harris CC. Urinary Metabolite Risk Biomarkers of Lung Cancer: A Prospective Cohort Study. Cancer Epidemiol Biomarkers Prev. 2016 Jun;25(6):978-86. doi: 10.1158/1055-9965.EPI-15-1191. Epub 2016 Mar 24. PMID: 27013655; PMCID: PMC4891298. 8: Xu Y, Lu H, Wang Y, Zhang Z, Wu Q. Comprehensive metabolic profiles of seminal plasma with different forms of male infertility and their correlation with sperm parameters. J Pharm Biomed Anal. 2020 Jan 5;177:112888. doi: 10.1016/j.jpba.2019.112888. Epub 2019 Sep 21. Erratum in: J Pharm Biomed Anal. 2020 May 30;184:113167. PMID: 31563758.