IUPAC/Chemical Name
diethyl 2,2'-(ethane-1,2-diylbis(azanediyl))(2R,2'R)-bis(3-mercaptopropanoate)
InChi Key
RZQNBTMGBODDSK-UWVGGRQHSA-N
InChi Code
InChI=1S/C12H24N2O4S2/c1-3-17-11(15)9(7-19)13-5-6-14-10(8-20)12(16)18-4-2/h9-10,13-14,19-20H,3-8H2,1-2H3/t9-,10-/m0/s1
SMILES Code
SC[C@@H](C(OCC)=O)NCCN[C@@H](CS)C(OCC)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
324.45
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Chao MY, Liu KT, Hsia YC, Liao MH, Shen LH. Direct determination of ECD in ECD Kit: a solid sample quantitation method for active pharmaceutical ingredient in drug product. J Biomed Biotechnol. 2011;2011:196238. doi: 10.1155/2011/196238. Epub 2011 Jun 9. PubMed PMID: 21687539; PubMed Central PMCID: PMC3114541.
2: Nobili F, Koulibaly PM, Rodriguez G, Benoit M, Girtler N, Robert PH, Brugnolo A, Darcourt J. 99mTc-HMPAO and 99mTc-ECD brain uptake correlates of verbal memory in Alzheimer's disease. Q J Nucl Med Mol Imaging. 2007 Dec;51(4):357-63. PubMed PMID: 17220817.
3: Koulibaly PM, Nobili F, Migneco O, Vitali P, Robert PH, Girtler N, Darcourt J, Rodriguez G. 99mTc-HMPAO and 99mTc-ECD perform differently in typically hypoperfused areas in Alzheimer's disease. Eur J Nucl Med Mol Imaging. 2003 Jul;30(7):1009-13. Epub 2003 May 15. PubMed PMID: 12750851.
4: Peremans K, Audenaert K, Blanckaert P, Jacobs F, Coopman F, Verschooten F, Van Bree H, Van Heeringen C, Mertens J, Slegers G, Dierckx R. Effects of aging on brain perfusion and serotonin-2A receptor binding in the normal canine brain measured with single photon emission tomography. Prog Neuropsychopharmacol Biol Psychiatry. 2002 Dec;26(7-8):1393-404. PubMed PMID: 12502029.
5: Otte A, Ettlin T, Fierz L, Mueller-Brand J. Parieto-occipital hypoperfusion in late whiplash syndrome: first quantitative SPET study using technetium-99m bicisate (ECD). Eur J Nucl Med. 1996 Jan;23(1):72-4. PubMed PMID: 8586106.
6: Walovitch RC, Cheesman EH, Maheu LJ, Hall KM. Studies of the retention mechanism of the brain perfusion imaging agent 99mTc-bicisate (99mTc-ECD). J Cereb Blood Flow Metab. 1994 Jan;14 Suppl 1:S4-11. PubMed PMID: 8263070.
